Abstract
The task of classifying X-ray data is a problem of both theoretical and clinical interest. Whilst supervised deep learning methods rely upon huge amounts of labelled data, the critical problem of achieving a good classification accuracy when an extremely small amount of labelled data is available has yet to be tackled. In this work, we introduce a novel semi-supervised framework for X-ray classification which is based on a graph-based optimisation model. To the best of our knowledge, this is the first method that exploits graph-based semi-supervised learning for X-ray data classification. Furthermore, we introduce a new multi-class classification functional with carefully selected class priors which allows for a smooth solution that strengthens the synergy between the limited number of labels and the huge amount of unlabelled data. We demonstrate, through a set of numerical and visual experiments, that our method produces highly competitive results on the ChestX-ray14 data set whilst drastically reducing the need for annotated data.
A.I. Aviles-Rivero and N. Papadakis—Equal Contribution.
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References
Bar, Y., Diamant, I., Wolf, L., Lieberman, S., Konen, E., Greenspan, H.: Chest pathology detection using deep learning with non-medical training. In: International Symposium on Biomedical Imaging (ISBI), pp. 294–297 (2015)
Belkin, M., Niyogi, P.: Laplacian eigenmaps for dimensionality reduction and data representation. Neural Comput. 15, 1373–1396 (2003)
Bresson, X., Laurent, T., Uminsky, D., Von Brecht, J.: Multiclass total variation clustering. In: Advances in Neural Information Processing Systems (2013)
Bruno, M.A., Walker, E.A., Abujudeh, H.H.: Understanding and confronting our mistakes: the epidemiology of error in radiology and strategies for error reduction. Radiographics 35(6), 1668–1676 (2015)
Bühler, T., Hein, M.: Spectral clustering based on the graph p-Laplacian. In: International Conference on Machine Learning (ICML) (2009)
Chambolle, A., Pock, T.: A first-order primal-dual algorithm for convex problems with applications to imaging. J. Math. Imaging Vis. 40, 120–145 (2011)
Chen, H., Li, K., Zhu, D.E.A.: Inferring group-wise consistent multimodal brain networks via multi-view spectral clustering. IEEE Trans. Med. Imaging (TMI) 32, 1576–1586 (2013)
Dodero, L., Gozzi, A., Liska, A., Murino, V., Sona, D.: Group-wise functional community detection through joint laplacian diagonalization. In: Golland, P., Hata, N., Barillot, C., Hornegger, J., Howe, R. (eds.) MICCAI 2014. LNCS, vol. 8674, pp. 708–715. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10470-6_88
Feld, T.M., Aujol, J.F., Gilboa, G., Papadakis, N.: Rayleigh quotient minimization for absolutely one-homogeneous functionals. Inverse Prob. 35, 064003 (2019)
Folio, L.R.: Chest Imaging: An Algorithmic Approach to Learning. Springer, New York (2012). https://doi.org/10.1007/978-1-4614-1317-2
Gao, Y., Adeli-M., E., Kim, M., Giannakopoulos, P., Haller, S., Shen, D.: Medical image retrieval using multi-graph learning for MCI diagnostic assistance. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9350, pp. 86–93. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24571-3_11
He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR) (2016)
Hein, M., Setzer, S., Jost, L., Rangapuram, S.S.: The total variation on hypergraphs-learning on hypergraphs revisited. In: Advances in Neural Information Processing Systems (2013)
Kohli, M.D., Summers, R.M., Geis, J.R.: Medical image data and datasets in the era of machine learning-whitepaper from the 2016 C-MIMI meeting dataset session. J. Digit. Imaging 30, 392–399 (2017)
Moradi, E., Pepe, A., Alzheimer’s Disease Neuroimaging Initiative et al.: Machine learning framework for early MRI-based Alzheimer’s conversion prediction in MCI subjects. Neuroimage 104, 398–412 (2015)
Toriwaki, J.I., Suenaga, Y., Negoro, T., Fukumura, T.: Pattern recognition of chest x-ray images. Comput. Graph. Image Process. 2, 252–271 (1973)
Wang, X., Peng, Y., Lu, L., Lu, Z., Bagheri, M., Summers, R.M.: ChestX-Ray8: hospital-scale chest x-ray database and benchmarks on weakly-supervised classification and localization of common thorax diseases. In: IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 2097–2106 (2017)
Wang, Z., et al.: Progressive graph-based transductive learning for multi-modal classification of brain disorder disease. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9900, pp. 291–299. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46720-7_34
Yao, L., Prosky, J., Poblenz, E., Covington, B., Lyman, K.: Weakly supervised medical diagnosis and localization from multiple resolutions. arXiv preprint arXiv:1803.07703 (2018)
Zhu, X., Ghahramani, Z., Lafferty, J.D.: Semi-supervised learning using Gaussian fields and harmonic functions. In: International conference on Machine learning (ICML), pp. 912–919 (2003)
Acknowledgments
AIAI is supported by the CMIH, University of Cambridge. NP is supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant No 777826. CBS acknowledges Leverhulme Trust (Breaking the non-convexity barrier), the Philip Leverhulme Prize, the EPSRC grants EP/M00483X/1 and EP/N014588/1, the European Union Horizon 2020, the Marie Skodowska-Curie grant 777826 NoMADS and 691070 CHiPS, the CCIMI and the Alan Turing Institute.
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Aviles-Rivero, A.I. et al. (2019). GraphX\(^\mathbf{\small NET } -\) Chest X-Ray Classification Under Extreme Minimal Supervision. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11769. Springer, Cham. https://doi.org/10.1007/978-3-030-32226-7_56
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DOI: https://doi.org/10.1007/978-3-030-32226-7_56
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