Abstract
Intracranial hemorrhage (ICH) is a fatal form of stroke which is caused by bleeding within or around the brain. Detection and quantification of hemorrhage are critical in the diagnosis and treatment of the disease. In this paper, we propose Siamese U-Net, to segment the abnormal regions of ICH more accurately from patients’ CT images. The Siamese U-Net is given a paired set of the patients’ CT images and a healthy template of the brain CT. We introduce the dissimilarity of hemorrhage regions from the healthy template to the long skip-connection in the U-Net architecture to emphasize the convolutional features of the abnormal regions by ICH. We evaluate the accuracy of the proposed architecture with a comparison of the baseline model. The proposed model shows significant improvement in Hausdorff distance (6.81%), dice score (9.07%), and volume percentage error (40.32%), compared to the baseline U-Net model. Regarding the healthy template, less both false-negative and false-positive regions are observed in the results of the Siamese U-Net. Consequently, the estimated blood volume by the Siamese U-Net is much closer to the actual volume than that of the baseline U-Net.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Heit, J.J., Iv, M., Wintermark, M.: Imaging of intracranial hemorrhage. J. Stroke 19(1), 11 (2017)
Parker Jr., D., Rhoney, D.H., Liu-DeRyke, X.: Management of spontaneous nontraumatic intracranial hemorrhage. J. Pharm. Pract. 23(5), 398–407 (2010)
Scherer, M., et al.: Development and validation of an automatic segmentation algorithm for quantification of intracerebral hemorrhage. Stroke 47(11), 2776–2782 (2016)
Prakash, K.B., Zhou, S., Morgan, T.C., Hanley, D.F., Nowinski, W.L.: Segmentation and quantification of intra-ventricular/cerebral hemorrhage in CT scans by modified distance regularized level set evolution technique. Int. J. Comput. Assist. Radiol. Surg. 7(5), 785–798 (2012)
He, K., Gkioxari, G., Dollár, P., Girshick, R.: Mask R-CNN. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2961–2969 (2017)
Chang, P., et al.: Hybrid 3D/2D convolutional neural network for hemorrhage evaluation on head CT. Am. J. Neuroradiol. 39(9), 1609–1616 (2018)
Koch, G., Zemel, R., Salakhutdinov, R.: Siamese neural networks for one-shot image recognition. In: ICML Deep Learning Workshop, vol. 2 (2015)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Nair, V., Hinton, G.E.: Rectified linear units improve restricted Boltzmann machines. In: Proceedings of the 27th International Conference on Machine Learning (ICML-10), pp. 807–814 (2010)
Horn, R.A.: The Hadamard product. In: Proceedings of Symposia in Applied Mathematics, vol. 40, pp. 87–169 (1990)
Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing internal covariate shift. arXiv preprint arXiv:1502.03167 (2015)
Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)
Zeiler, M.D., Krishnan, D., Taylor, G.W., Fergus, R.: Deconvolutional networks (2010)
Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)
Rorden, C., Bonilha, L., Fridriksson, J., Bender, B., Karnath, H.O.: Age-specific CT and MRI templates for spatial normalization. Neuroimage 61(4), 957–965 (2012)
Jenkinson, M., Bannister, P., Brady, M., Smith, S.: Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17(2), 825–841 (2002)
Kim, J., Kim, S., Lee, M.: Convolutional neural network with biologically inspired ON/OFF ReLU. In: Arik, S., Huang, T., Lai, W.K., Liu, Q. (eds.) ICONIP 2015. LNCS, vol. 9492, pp. 316–323. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-26561-2_38
Acknowledgement
This work was supported by Institute for Information & communications Technology Promotion (IITP) grant funded by the Korea government (MSIT) (2018-2-00861, Intelligent SW Technology Development for Medical Data Analysis) and Institute of Information & Communications Technology Planning & Evaluation (IITP) grant funded by the Korea government (MSIT) (2016-0-00564, Development of Intelligent Interaction Technology Based on Context Awareness and Human Intention Understanding).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Kwon, D. et al. (2019). Siamese U-Net with Healthy Template for Accurate Segmentation of Intracranial Hemorrhage. In: Shen, D., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. MICCAI 2019. Lecture Notes in Computer Science(), vol 11766. Springer, Cham. https://doi.org/10.1007/978-3-030-32248-9_94
Download citation
DOI: https://doi.org/10.1007/978-3-030-32248-9_94
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-32247-2
Online ISBN: 978-3-030-32248-9
eBook Packages: Computer ScienceComputer Science (R0)