Abstract
Cone-beam computed tomography (CBCT) has been widely used in image-guided radiation therapy for patient setup to improve treatment performance. However, the low soft tissue contrast on CBCT may limit its utility when soft tissue alignment is of interest. Moreover, the potential application of CBCT in adaptive radiation therapy also requires superior soft tissue contrast for online target and organ-at-risk delineation and localization. The purpose of this study is to develop a deep learning-based approach to generate synthetic MRI (sMRI) from CBCT to provide a high soft tissue contrast on CBCT anatomy. The proposed method integrates a dense block and self-attention concept into a cycle-consistent adversarial network (cycleGAN) framework, called attention-cycleGAN, to learn a mapping between CBCT images and paired MRI. Compared with a GAN, a cycleGAN includes an inverse transformation from CBCT to MRI, which constrains the model by forcing a one-to-one mapping. A fully convolution neural network (FCN) with U-Net architecture is used in the generator to enable end-to-end CBCT-to-MRI transformations. Dense blocks and self-attention strategy are used to learn the information to well represent the CBCT image and to map to the specific MRI structure. The experimental results demonstrated that the proposed method could accurately generate sMRI with a similar soft-tissue contract as real MRI.
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References
Harms, J., et al.: Paired cycle-GAN-based image correction for quantitative cone-beam computed tomography. Med. Phys. 46, 3998–4009 (2019)
Lei, Y., et al.: Learning-based CBCT correction using alternating random forest based on auto-context model. Med. Phys. 46(2), 601–618 (2019)
Hvid, C.A., Elstrom, U.V., Jensen, K., Grau, C.: Cone-beam computed tomography (CBCT) for adaptive image guided head and neck radiation therapy. Acta Oncol. 57(4), 552–556 (2018)
Yang, X., et al.: A learning-based method to improve pelvis cone beam CT image quality for prostate cancer radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 102(3), e377–e378 (2018)
Barney, B.M., Lee, R.J., Handrahan, D., Welsh, K.T., Cook, J.T., Sause, W.T.: Image-guided radiotherapy (IGRT) for prostate cancer comparing kV imaging of fiducial markers with cone beam computed tomography (CBCT). Int. J. Radiat. Oncol. Biol. Phys. 80(1), 301–305 (2011)
Kataria, T., et al.: Clinical outcomes of adaptive radiotherapy in head and neck cancers. Br. J. Radiol. 89(1062), 20160085 (2016)
Oldham, M., et al.: Cone-beam-CT guided radiation therapy: a model for on-line application. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 75(3), 271–278 (2005)
Yoo, S., Yin, F.: Dosimetric feasibility of cone-beam CT-based treatment planning compared to CT-based treatment planning. Int. J. Radiat. Oncol. Biol. Phys. 66(5), 1553–1561 (2006)
de la Zerda, A., Armbruster, B., Xing, L.: Formulating adaptive radiation therapy (ART) treatment planning into a closed-loop control framework. Phys. Med. Biol. 52(14), 4137–4153 (2007)
Thor, M., Petersen, J.B., Bentzen, L., Hoyer, M., Muren, L.P.: Deformable image registration for contour propagation from CT to cone-beam CT scans in radiotherapy of prostate cancer. Acta Oncol. 50(6), 918–925 (2011)
Yang, X., et al.: Pseudo CT estimation from MRI using patch-based random forest. In: Proceedings of SPIE, pp. 101332Q (2017)
Yang, X., et al.: A learning-based approach to derive electron density from anatomical MRI for radiation therapy treatment planning. Int. J. Radiat. Oncol. 99(2), S173–S174 (2017)
Wang, T., et al.: MRI-based treatment planning for brain stereotactic radiosurgery: dosimetric validation of a learning-based pseudo-CT generation method. Med. Dosim. Official J. Am. Assoc. Med. Dosimetrists 44, 199–204 (2019)
Lei, Y., et al.: MRI-based pseudo CT synthesis using anatomical signature and alternating random forest with iterative refinement model. J. Med. Imaging. 5(4), 043504 (2018)
Yang, X., et al.: MRI-Based synthetic CT for radiation treatment of prostate cancer. Int. J. Radiat. Oncol. 102(3), S193–S194 (2018)
Shafai-Erfani, G., et al.: Dose evaluation of MRI-based synthetic CT generated using a machine learning method for prostate cancer radiotherapy. Med. Dosim. Official J. Am. Assoc. Med. Dosimetrists (2019, in press)
Lei, Y., et al.: MRI-only based synthetic CT generation using dense cycle consistent generative adversarial networks. Med. Phys. 46(8), 3565–3581 (2019)
Acknowledgements
This research is supported in part by the National Cancer Institute of the National Institutes of Health under Award Number R01CA215718, and Dunwoody Golf Club Prostate Cancer Research Award, a philanthropic award provided by the Winship Cancer Institute of Emory University.
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Lei, Y. et al. (2019). CBCT-Based Synthetic MRI Generation for CBCT-Guided Adaptive Radiotherapy. In: Nguyen, D., Xing, L., Jiang, S. (eds) Artificial Intelligence in Radiation Therapy. AIRT 2019. Lecture Notes in Computer Science(), vol 11850. Springer, Cham. https://doi.org/10.1007/978-3-030-32486-5_19
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DOI: https://doi.org/10.1007/978-3-030-32486-5_19
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