A Device-Independent Novel Statistical Modeling for Cerebral TOF-MRA Data Segmentation

Abstract

Among the model-driven segmentation methods, the Maximum a Posterior (MAP) & Markov Random Field (MRF) is the popular statistical framework. However, there remains a dominating limitation in the existing statistical modeling, i.e., the data imaged by MR scanners with different types and parameters cannot be adaptively processed to lead accurate and robust vessel segmentation, as is well-known to the researchers in this field. Our methodology steps contribute as: (1) a region-histogram standardization strategy is explored to the time-of-flight magnetic resonance angiography data; (2) a Gaussian mixture models (GMM) is constructed with three Gaussian distributions and a knowledge-based expectation-maximization algorithm is explored to obtain the GMM parameters; (3) a probability feature map is captured according the estimated vascular distribution weight in GMM and then is embedded into the Markov high-level process to relieve the label field noise and rich the vascular structure. Our method wins out the other models with better segmentation accuracy and the sensibility to small-sized vessels or large arteriovenous malformation mass, which is validated on three different datasets and obtains satisfying results on visual and quantitative evaluation with Dice similarity coefficient and positive predictive value of 89.12% and 95.66%.

This work was funded by the National Natural Science Foundation of China (No. 81827805), National Key R&D Program of China (No. 2018YFA0704102) and supported by the Key Laboratory of Health Informatics in Chinese Academy of Sciences, and also by Shenzhen Engineering Laboratory for Key Technology on Intervention Diagnosis and Treatment Integration.