Skip to main content
SpringerLink
Log in

Influence of Sarcopenia on Bone Health Parameters in a Group of Elderly Lebanese Men

  • Conference paper
  • First Online:
Bioinformatics and Biomedical Engineering (IWBBIO 2020)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 12108))

  • 1593 Accesses

Abstract

Sarcopenia is a disease characterized by the loss of muscle mass and strength. The aim of the current study was to explore the influence of sarcopenia on bone health parameters in a group of elderly Lebanese men. To do so, we compared bone health parameters (Bone Mineral Content (BMC), Bone Mineral Density (BMD) and femoral neck geometry indices) in a group of elderly men with sarcopenia and a group of elderly men with normal Skeletal Muscle mass Index (SMI). 23 sarcopenic men (SMI < 7 kg/m2) and 23 men with normal SMI (>7 kg/m2) participated in our study. Body composition and bone variables were measured by Dual-energy X-ray Absorptiometry (DXA). DXA measurements were completed for the Whole Body (WB), Lumbar spine (L1–L4), Total Hip (TH) and Femoral Neck (FN). Hip geometry parameters including Cross-Sectional Area (CSA), Cross-Sectional Moment of Inertia (CSMI), section modulus (Z), Strength Index (SI) and Buckling Ratio (BR) were derived by DXA. Age and height were not significantly different between the two groups. Weight, Body Mass Index (BMI), lean mass, fat mass, appendicular lean mass, SMI, WB BMC, TH BMD, FN BMD, CSA, CSMI and Z were significantly higher in non-sarcopenic men compared to sarcopenic men. In the whole population, lean mass was the strongest determinant of bone health parameters. After adjusting for lean mass, there were no significant differences regarding bone health parameters between the two groups. In conclusion, the present study suggests that sarcopenia negatively influences bone health parameters in elderly Lebanese men.

A. Antoun and H. Saddick—The first two authors contributed equally to this manuscript.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Beck, T.J.: Extending DXA beyond bone mineral density: understanding hip structure analysis. Curr. Osteoporos Rep. 5(2), 49–55 (2007). https://doi.org/10.1007/s11914-007-0002-4

    Article  PubMed  Google Scholar 

  2. Friedman, A.W.: Important determinants of bone strength: beyond bone mineral density. J. Clin. Rheumatol. 12(2), 70–77 (2006)

    Article  PubMed  Google Scholar 

  3. Ammann, P., Rizzoli, R.: Bone strength and its determinants. Osteoporos. Int. 14(Suppl 3), S13–S18 (2003)

    Article  PubMed  Google Scholar 

  4. Fonseca, H., Moreira-Gonçalves, D., Coriolano, H.-J., Duarte, J.A.: Bone quality: the determinants of bone strength and fragility. Sports Med. 44(1), 37–53 (2013). https://doi.org/10.1007/s40279-013-0100-7

    Article  Google Scholar 

  5. Rizzoli, R., Bonjour, J.P., Ferrari, S.L.: Osteoporosis, genetics and hormones. J. Mol. Endocrinol. 26(2), 79–94 (2001)

    Article  CAS  PubMed  Google Scholar 

  6. Beck, B.R., Snow, C.M.: Bone health across the lifespan–exercising our options. Exerc. Sport Sci. Rev. 31(3), 117–122 (2003)

    Article  PubMed  Google Scholar 

  7. Petit, M.A., Beck, T.J., Kontulainen, S.A.: Examining the developing bone: What do we measure and how do we do it? J. Musculoskelet. Neuronal Interact. 5(3), 213–224 (2005)

    CAS  PubMed  Google Scholar 

  8. Goltzman, D.: The Aging Skeleton. Adv. Exp. Med. Biol. 1164, 153–160 (2019)

    Article  PubMed  Google Scholar 

  9. Min, S.K., et al.: Position statement: exercise guidelines to increase peak bone mass in adolescents. J. Bone Metab. 26(4), 225–239 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  10. Monge, M.C.: Optimizing bone health in adolescents. Curr. Opin. Obstet. Gynecol. 30(5), 310–315 (2018)

    PubMed  Google Scholar 

  11. Bonjour, J.P., Chevalley, T., Rizzoli, R., Ferrari, S.: Gene-environment interactions in the skeletal response to nutrition and exercise during growth. Med. Sport Sci. 51, 64–80 (2007)

    Article  PubMed  Google Scholar 

  12. Bonjour, J.P., Chevalley, T., Ferrari, S., Rizzoli, R.: The importance and relevance of peak bone mass in the prevalence of osteoporosis. Salud Publica Mex. 51(Suppl 1), S5–S17 (2009)

    PubMed  Google Scholar 

  13. Bonjour, J.P., Chevalley, T.: Pubertal timing, bone acquisition, and risk of fracture throughout life. Endocr. Rev. 35(5), 820–847 (2014)

    Article  CAS  PubMed  Google Scholar 

  14. El Hage, R., Jacob, C., Moussa, E., Jaffré, C., Baddoura, R.: Bone mass in a group of Lebanese girls from Beirut and French girls from Orleans. J. Med. Liban. 59(3), 131–135 (2011)

    PubMed  Google Scholar 

  15. El Hage, R., Baddoura, R.: Anthropometric predictors of geometric indices of hip bone strength in a group of Lebanese postmenopausal women. J Clin Densitom. 15(2), 191–197 (2012)

    Article  PubMed  Google Scholar 

  16. El Hage, R., Jacob, C., Moussa, E., Baddoura, R.: Relative importance of lean mass and fat mass on bone mineral density in a group of Lebanese postmenopausal women. J. Clin. Densitom. 14(3), 326–331 (2011)

    Article  PubMed  Google Scholar 

  17. Ayoub, M.L., et al.: DXA-based variables and osteoporotic fractures in Lebanese postmenopausal women. Orthop. Traumatol. Surg. Res. 100(8), 855–858 (2014)

    Article  PubMed  Google Scholar 

  18. Hage, R.E., Bachour, F., Sebaaly, A., Issa, M., Zakhem, E., Maalouf, G.: The influence of weight status on radial bone mineral density in lebanese women. Calcif. Tissue Int. 94(4), 465–467 (2013). https://doi.org/10.1007/s00223-013-9822-7

    Article  CAS  PubMed  Google Scholar 

  19. El Hage, R., et al.: Influence of age, morphological characteristics, and lumbar spine bone mineral density on lumbar spine trabecular bone score in Lebanese women. J. Clin. Densitom. 17(3), 434–435 (2014)

    Article  PubMed  Google Scholar 

  20. Maalouf, G., et al.: Epidemiology of hip fractures in Lebanon: a nationwide survey. Orthop. Traumatol. Surg. Res. 99(6), 675–680 (2013)

    Article  CAS  PubMed  Google Scholar 

  21. El Hage, R., Mina, F., Ayoub, M.L., Theunynck, D., Baddoura, R.: Relative importance of lean mass and fat mass on bone mineral density in a group of Lebanese elderly men. J. Med. Liban. 60(3), 136–141 (2012)

    PubMed  Google Scholar 

  22. El Hage, R., Theunynck, D., Rocher, E., Baddoura, R.: Geometric indices of hip bone strength in overweight and control elderly men. J. Med. Liban. 62(3), 150–155 (2014)

    PubMed  Google Scholar 

  23. El-Hajj Fuleihan, G., Baddoura, R., Awada, H., Salam, N., Salamoun, M., Rizk, P.: Low peak bone mineral density in healthy Lebanese subjects. Bone 31(4), 520–528 (2002)

    Article  CAS  PubMed  Google Scholar 

  24. Arabi, A., et al.: Bone mineral density by age, gender, pubertal stages, and socioeconomic status in healthy Lebanese children and adolescents. Bone 35(5), 1169–1179 (2004)

    Article  PubMed  Google Scholar 

  25. El Hage, R., Jacob, C., Moussa, E., Jaffré, C., Benhamou, C.L.: Daily calcium intake and body mass index in a group of Lebanese adolescents. J. Med. Liban. 57(4), 253–257 (2009)

    PubMed  Google Scholar 

  26. Salamoun, M.M., et al.: Low calcium and vitamin D intake in healthy children and adolescents and their correlates. Eur. J. Clin. Nutr. 59(2), 177–184 (2005)

    Article  CAS  PubMed  Google Scholar 

  27. Gannagé-Yared, M.H., Chemali, R., Yaacoub, N., Halaby, G.: Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J. Bone Miner. Res. 15(9), 1856–1862 (2000)

    Article  PubMed  Google Scholar 

  28. Gannagé-Yared, M.H., Chemali, R., Sfeir, C., Maalouf, G., Halaby, G.: Dietary calcium and vitamin D intake in an adult Middle Eastern population: food sources and relation to lifestyle and PTH. Int. J. Vitam. Nutr. Res. 75(4), 281–289 (2005)

    Article  PubMed  CAS  Google Scholar 

  29. Fazah, A., Jacob, C., Moussa, E., El-Hage, R., Youssef, H., Delamarche, P.: Activity, inactivity and quality of life among Lebanese adolescents. Pediatr. Int. 52(4), 573–578 (2010)

    Article  PubMed  Google Scholar 

  30. Nasreddine, L., et al.: Dietary, lifestyle and socio-economic correlates of overweight, obesity and central adiposity in Lebanese children and adolescents. Nutrients 6(3), 1038–1062 (2014)

    Article  PubMed  PubMed Central  Google Scholar 

  31. Naja, F., Hwalla, N., Itani, L., Karam, S., Sibai, A.M., Nasreddine, L.: A Western dietary pattern is associated with overweight and obesity in a national sample of Lebanese adolescents (13–19 years): a cross-sectional study. Br. J. Nutr. 114(11), 1909–1919 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. El Hage, Z., et al.: Bone mineral content and density in obese, overweight and normal weight adolescent boys. J. Med. Liban. 61(3), 148–154 (2013)

    PubMed  Google Scholar 

  33. El Hage, R.: Geometric indices of hip bone strength in obese, overweight, and normal-weight adolescent boys. Osteoporos. Int. 23(5), 1593–1600 (2012)

    Article  PubMed  Google Scholar 

  34. Arabi, A., Baddoura, R., Awada, H., Salamoun, M., Ayoub, G., El-Hajj, F.G.: Hypovitaminosis D osteopathy: is it mediated through PTH, lean mass, or is it a direct effect? Bone 39(2), 268–275 (2006)

    Article  CAS  PubMed  Google Scholar 

  35. Arabi, A., Baddoura, R., El-Rassi, R., El-Hajj, F.G.: Age but not gender modulates the relationship between PTH and vitamin D. Bone 47(2), 408–412 (2010)

    Article  CAS  PubMed  Google Scholar 

  36. Cruz-Jentoft, A.J., et al.: Writing group for the European working group on Sarcopenia in older people 2 (EWGSOP2), and the extended group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(4), 601 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  37. Beaudart C, et al.: Sarcopenia in daily practice: assessment and management. BMC Geriatr. 16(1):170 (2016)

    Google Scholar 

  38. Dhillon, R.J., Hasni, S.: Pathogenesis and management of Sarcopenia. Clin. Geriatr. Med. 33(1), 17–26 (2017)

    Article  PubMed  PubMed Central  Google Scholar 

  39. Hirschfeld, H.P., Kinsella, R., Duque, G.: Osteosarcopenia: where bone, muscle, and fat collide. Osteoporos. Int. 28(10), 2781–2790 (2017)

    Article  CAS  PubMed  Google Scholar 

  40. Khawaja, A., et al.: Does muscular power predict bone mineral density in young adults? J. Clin. Densitom. 22(3), 311–320 (2019)

    Article  PubMed  Google Scholar 

  41. Berro, A.J., et al.: Physical performance variables and bone parameters in a group of young overweight and obese women. J Clin Densitom. 22(2), 293–299 (2019)

    Article  PubMed  Google Scholar 

  42. Al Rassy, N., et al.: The relationships between bone variables and physical fitness across the BMI spectrum in young adult women. J. Bone Miner. Metab. 37(3), 520–528 (2019)

    Article  PubMed  Google Scholar 

  43. Nasr R, et al: Muscular maximal strength indices and bone variables in a group of elderly women. J. Clin. Densitom. 2018 pii: S1094–6950(18)30014-3. https://doi.org/10.1016/j.jocd.2018.03.003

  44. El Khoury, G., et al.: Bone Variables in active overweight/obese men and sedentary overweight/obese men. J. Clin. Densitom. 20(2), 239–246 (2017)

    Article  PubMed  Google Scholar 

  45. El Khoury, C., et al.: Physical performance variables and bone mineral density in a group of young overweight and obese men. J. Clin. Densitom. 21(1), 41–47 (2018)

    Article  PubMed  Google Scholar 

  46. Zakhem, E., et al.: Performance physique et densité minérale osseuse chez de jeunes adultes libanais. J. Med. Liban. 64(4), 193–199 (2016)

    PubMed  Google Scholar 

  47. El Hage, R., et al.: Maximal oxygen consumption and bone mineral density in a group of young Lebanese adults. J. Clin. Densitom. 17(2), 320–324 (2014)

    Article  PubMed  Google Scholar 

  48. Roberts, H.C., et al.: A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing 40(4), 423–429 (2011)

    Article  PubMed  Google Scholar 

  49. Reiss, J., et al.: Sarcopenia and osteoporosis are interrelated in geriatric inpatients. Z. Gerontol. Geriatr. 52(7), 688–693 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Qi, H., et al.: Bone mineral density and trabecular bone score in Chinese subjects with sarcopenia. Aging Clin. Exp. Res. 31(11), 1549–1556 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  51. Wong, R.M.Y., et al.: The relationship between sarcopenia and fragility fracture-a systematic review. Osteoporos. Int. 30(3), 541–553 (2019)

    Article  CAS  PubMed  Google Scholar 

  52. Nasr, R., Watelain, E., Pinti, A., Maalouf, G., Berro, A.J., El Hage, R.: Sarcopenia and hip structure analysis variables in a group of elderly men. J Clin Densitom. 21(2), 312–313 (2018)

    Article  PubMed  Google Scholar 

Download references

Conflicts of Interest

The authors state that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Physical Education, Faculty of Arts and Social Sciences, University of Balamand, El-Koura, Lebanon

    Amal Antoun, Hayman Saddick, Riad Nasr & Rawad El Hage

  2. Laboratoire IAPS, Université de Toulon, Toulon, France

    Amal Antoun & Eric Watelain

  3. Laboratoire I3MTO EA 4708, University of Orléans, 45067, Orléans, France

    Hayman Saddick, Eric Lespessailles & Hechmi Toumi

  4. Design, Visuel, Urbain, EA 2445, UPHF, Valenciennes, France

    Antonio Pinti

  5. Plateforme Recherche Innovation Médicale Mutualisée d’Orléans, Centre Hospitalier Régional d’Orléans, 14 Avenue de l’Hôpital, 45100, Orléans, France

    Eric Lespessailles & Hechmi Toumi

Authors
  1. Amal Antoun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hayman Saddick
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonio Pinti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Riad Nasr
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eric Watelain
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Eric Lespessailles
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hechmi Toumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Rawad El Hage
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Antonio Pinti .

Editor information

Editors and Affiliations

  1. University of Granada, Granada, Spain

    Ignacio Rojas

  2. University of Granada, Granada, Spain

    Olga Valenzuela

  3. University of Granada, Granada, Spain

    Fernando Rojas

  4. University of Granada, Granada, Spain

    Luis Javier Herrera

  5. University of Chicago and Fundacion Progreso y Salud, Granada, Spain

    Francisco Ortuño

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Antoun, A. et al. (2020). Influence of Sarcopenia on Bone Health Parameters in a Group of Elderly Lebanese Men. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science(), vol 12108. Springer, Cham. https://doi.org/10.1007/978-3-030-45385-5_60

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-45385-5_60

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45384-8

  • Online ISBN: 978-3-030-45385-5

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics

Search

Navigation