Abstract
Any serious medical research involves the use of information technologies of statistical analysis in processing the results of clinical observations, experimental data and measurements. In the paper the survival analysis patients by the medical database of pancreatic cancer in Krasnoyarsk Territory is represented. Survival analysis is based on the survival function. Survival function modeling was performed on the basis of three approaches: parametric, semi-parametric and non-parametric. The survival model was fitted on the base of the selection of distributions. The closest distribution is the Weibull distribution. Semiparametric modeling made it possible to construct a survival curve for a combination of prognostic factors based on the Cox proportional risk regression model. Two parameters were identified as prognostic for survival: distant metastases, number of chemotherapy courses taken. An assessment was made of the overall survival of patients with pancreatic cancer and an assessment of the survival of patients after surgical and chemotherapeutic treatment in various subgroups by age and gender using the non-parametric Kaplan-Meier method #CSOC1120.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kaprin, A.D., Starinskiy, V.V., Petrova, G.V.: Malignant neoplasms in Russia in 2018 (morbidity and mortality). In: Hertsen, P.A. (ed.) Moscow Oncology Research Center – Branch of FSBI NMRRC of the Ministry of Health of Russia, Moscow (2019). (in Russian)
Okladnikova, E.V., Ruksha, T.G.: Analysis of hospital morbidity for pancreatic cancer in Krasnoyarsk krai. Siberian J. Oncol. 6, 61–67 (2015). (in Russian)
Glantz, S.A.: Primer of Biostatistics, 7th edn. McGraw-Hill Medical, New York (2012). (in Russian)
Slinin, A.S., Bydanov, O.I., Karachunskiy, A.I.: Analysis of survival and possibility of certain events in patients with acute leucosis. Pediatr. Haematol. Oncol. Immunopathol. 15(3), 34–39 (2016). https://doi.org/10.20953/1726-1708-2016-3-34-39. (in Russian)
Zulkarnaev, A.B.: Features of survival analysis on patients on the «waiting list» for kidney transplantation. Bull. Siberian Med. 18(2), 215–222 (2019). https://doi.org/10.20538/1682-0363-2019-2-215-222. (in Russian)
Ohno-Machado, L.: Modeling medical prognosis: survival analysis techniques. J. Biomed. Inform. 34, 428–439 (2002). https://doi.org/10.1006/jbin.2002.1038
Clark, T., Bradburn, M., Love, S., et al.: Survival analysis Part I: basic concepts and first analyses. Br. J. Cancer 89, 232–238 (2003). https://doi.org/10.1038/sj.bjc.6601118
Kaplan, E.L., Meier, P.: Non-parametric estimation for incomplete observations. J. Am. Stat. Assoc. 53, 457–481 (1958)
Bradburn, M., Clark, T., Love, S., et al.: Survival analysis Part II: multivariate data analysis - an introduction to concepts and methods. Br. J. Cancer 89, 431–436 (2003). https://doi.org/10.1038/sj.bjc.6601119
Borovikov, V.P.: Popular introduction to modern data analysis in the STATISTICA system: methodology and technology of modern data analysis: tutorial. Goryachaya linia - Telekom, Moscow (in Russian) (2014)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Kazarin, A., Lukyanova, N., Melnikova, O. (2020). Modeling and Analysis of Survival to Patients of Pancreatic Cancer in Krasnoyarsk Territory. In: Silhavy, R. (eds) Applied Informatics and Cybernetics in Intelligent Systems. CSOC 2020. Advances in Intelligent Systems and Computing, vol 1226. Springer, Cham. https://doi.org/10.1007/978-3-030-51974-2_56
Download citation
DOI: https://doi.org/10.1007/978-3-030-51974-2_56
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-51973-5
Online ISBN: 978-3-030-51974-2
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)