Abstract
We present in this article, for the area of structural and functional genetics, a preliminary theoretical model based on the representation of transcriptomes and proteomes as families of formal languages, in which the phenomenon of translation is described as a artificial language transduction process (present in programming languages compilers), making it possible to unify the transcriptomic and proteomic data.
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References
Bartocci, E., Lió, P.: Computational modeling, formal analysis, and tools for systems biology. PLoS Comput. Biol. 12(1), e1004591 (2016)
Berstel, J.: Transductions and Context-Free Languages. Springer, Heidelberg (2013)
Berstel, J., Perrin, D., Reutenauer, C.: Codes and Automata, vol. 129. Cambridge University Press, Cambridge (2010)
Bessant, C., et al.: Proteome informatics. Royal Society of Chemistry (2016)
Butcher, E.C., Berg, E.L., Kunkel, E.J.: Systems biology in drug discovery. Nat. Biotechnol. 22(10), 1253–1259 (2004)
Cellerino, A., Sanguanini, M.: Transcriptome Analysis: Introduction and Examples from the Neurosciences, vol. 17. Springer, Heidelberg (2018). https://doi.org/10.1007/978-88-7642-642-1
Datta, S., Mukhopadhyay, S.: A grammar inference approach for predicting kinase specific phosphorylation sites. PLoS One 10(4), e0122294 (2015)
Fan, M., et al.: Integration of deep transcriptome and proteome analyses of salicylic acid regulation high temperature stress in ulva prolifera. Sci. Rep. 7(1), 1–19 (2017)
Gross, F.: The impact of formal reasoning in computational biology. In: Bertolaso, M., Sterpetti, F. (eds.) A Critical Reflection on Automated Science. HPHST, vol. 1, pp. 139–155. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-25001-0_7
Hartwell, L., Goldberg, M.L., Fischer, J.A., Hood, L.E., Aquadro, C.F.: Genetics: from Genes to Genomes. McGraw-Hill, New York (2008)
Hopcroft, J.E.: Introduction to Automata Theory, Languages, and Computation. Pearson Addison Wesley, Boston (2007)
Kahl, G.: The Dictionary of Genomics, Transcriptomics and Proteomics. Wiley, Hoboken (2015)
Kitano, H.: Systems biology: a brief overview. Science 295(5560), 1662–1664 (2002)
Klug, W.S., Cummings, M.R., Spencer, C.A., Palladino, M.A.: Concepts of Genetics. Benjamin Cummings, San Francisco (2014)
Kumar, D., Bansal, G., Narang, A., Basak, T., Abbas, T., Dash, D.: Integrating transcriptome and proteome profiling: strategies and applications. Proteomics 16(19), 2533–2544 (2016)
Nutaro, J.J.: Building Software for Simulation: Theory and Algorithms, with Application in C++. Wiley Online Library, Hoboken (2011)
Pierce, B.A.: Genetics: A Conceptual Approach. Macmillan, New York (2012)
Rozenberg, G., Salomaa, A.: Handbook of Formal Languages: Volume 3 Beyond Words. Springer, Heidelberg (2012)
Searls, D.B.: The language of genes. Nature 420(6912), 211–217 (2002)
Sempere, J.M.: On compensation loops in genomic duplications. Int. J. Found. Comput. Sci. 31(01), 133–142 (2020)
Zhu, W., et al.: Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol. Lett. 312, 1–10 (2019)
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da Silva Filho, R.I., de Azevedo da Rocha, R.L., Oliveira, C.S. (2020). Formal Language Model for Transcriptome and Proteome Data Integration. In: Gervasi, O., et al. Computational Science and Its Applications – ICCSA 2020. ICCSA 2020. Lecture Notes in Computer Science(), vol 12253. Springer, Cham. https://doi.org/10.1007/978-3-030-58814-4_60
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DOI: https://doi.org/10.1007/978-3-030-58814-4_60
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