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Attention, Suggestion and Annotation: A Deep Active Learning Framework for Biomedical Image Segmentation

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Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 (MICCAI 2020)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12261))

Abstract

Despite the great success, deep learning based segmentation methods still face a critical obstacle: the difficulty in acquiring sufficient training data due to high annotation costs. In this paper, we propose a deep active learning framework that combines the attention gated fully convolutional network (ag-FCN) and the distribution discrepancy based active learning algorithm (dd-AL) to significantly reduce the annotation effort by iteratively annotating the most informative samples to train the ag-FCN for the better segmentation performance. Our framework is evaluated on 2015 MICCAI Gland Segmentaion dataset and 2017 MICCAI 6-month infant brain MRI Segmentation dataset. Experiment results show that our framework can achieve state-of-the-art segmentation performance by using only a portion of the training data.

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Notes

  1. 1.

    In this paper, the labeled set and unlabeled set refer to the labeled and unlabeled portions of a training dataset, respectively.

  2. 2.

    The encoding part of each ag-FCN can be utilized as a feature extractor. Given an input image to K ag-FCNs, the average of outputs of Layer 6 in these ag-FCNs can be viewed as a high-dimensional feature representation of the input image.

  3. 3.

    We replace all 2D operations with 3D operations (e.g., 2D conv \(\rightarrow \) 3D conv, etc.).

References

  1. Kamnitsas, K., Ledig, C., et al.: Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med. Image Anal. 36, 61–78 (2017)

    Article  Google Scholar 

  2. Liao, F., Liang, M., et al.: Evaluate the malignancy of pulmonary nodules using the 3-D deep leaky noisy-or network. IEEE Trans. Neural Netw. Learn. Syst. 30(11), 3484–3495 (2019)

    Article  Google Scholar 

  3. Long, J., Shelhamer, E., et al.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3431–3440 (2015)

    Google Scholar 

  4. He, K., Gkioxari, G., et al.: Mask R-CNN. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2961–2969 (2017)

    Google Scholar 

  5. Papandreou, G., Chen, L.C., et al.: Weakly-and semi-supervised learning of a DCNN for semantic image segmentation. arXiv, arXiv preprint arXiv:1502.02734 (2015)

  6. Xiao, H., Wei, Y., et al.: Transferable semi-supervised semantic segmentation. In: AAAI Conference on Artificial Intelligence (2018)

    Google Scholar 

  7. Hong, S., Noh, H., et al.: Decoupled deep neural network for semi-supervised semantic segmentation. In: Advances in Neural Information Processing Systems, pp. 1495–1503 (2015)

    Google Scholar 

  8. Settles, B.: Active learning literature survey. University of Wisconsin-Madison Department of Computer Sciences (2009)

    Google Scholar 

  9. Dutt Jain, S., Grauman, K.: Active image segmentation propagation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2864–2873 (2016)

    Google Scholar 

  10. Yang, L., Zhang, Y., et al.: Suggestive annotation: a deep active learning framework for biomedical image segmentation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 399–407 (2017)

    Google Scholar 

  11. Wang, X., Girshick, R., et al.: Non-local neural networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 7794–7803 (2018)

    Google Scholar 

  12. Sirinukunwattana, K., Pluim, J.P., et al.: Gland segmentation in colon histology images: the glas challenge contest. Med. Image Anal. 35, 489–502 (2017)

    Article  Google Scholar 

  13. Wang, L., Nie, D., et al.: Benchmark on automatic six-month-old infant brain segmentation algorithms: the iSeg-2017 challenge. IEEE Trans. Med. Imaging 38(9), 2219–2230 (2019)

    Article  Google Scholar 

  14. Graham, S., Chen, H., et al.: MILD-Net: minimal information loss dilated network for gland instance segmentation in colon histology images. Med. Image Anal. 52, 199–211 (2019)

    Article  Google Scholar 

  15. Graham, S., Chen, H., et al.: DCAN: deep contour-aware networks for accurate gland segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2487–2496 (2016)

    Google Scholar 

  16. Ding, H., Pan, Z., et al.: Multi-scale fully convolutional network for gland segmentation using three-class classification. Neurocomputing 380, 150–161 (2020)

    Article  Google Scholar 

  17. TESLA V100 Performance Guide. https://www.nvidia.com/content/dam/en-zz/Solutions/Data-Center/tesla-product-literature/v100-application-performance-guide.pdf

  18. Çiçek, Ö., Abdulkadir, A., et al.: 3D U-Net: learning dense volumetric segmentation from sparse annotation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 424–432 (2016)

    Google Scholar 

  19. Chen, H., Dou, Q., et al.: VoxResNet: deep voxelwise residual networks for brain segmentation from 3D MR images. NeuroImage 170, 446–455 (2018)

    Article  Google Scholar 

  20. Bui, T.D., Shin, J., et al.: Skip-connected 3D DenseNet for volumetric infant brain MRI segmentation. Biomed. Signal Process. Control 54, 101613 (2019)

    Article  Google Scholar 

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Correspondence to Haohan Li .

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Li, H., Yin, Z. (2020). Attention, Suggestion and Annotation: A Deep Active Learning Framework for Biomedical Image Segmentation. In: Martel, A.L., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. MICCAI 2020. Lecture Notes in Computer Science(), vol 12261. Springer, Cham. https://doi.org/10.1007/978-3-030-59710-8_1

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  • DOI: https://doi.org/10.1007/978-3-030-59710-8_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-59709-2

  • Online ISBN: 978-3-030-59710-8

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