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Introducing Drugonfly; A Novel Computer-Aided Drug Repurposing Pipeline Based on Genomic, Structural and Physicochemical Profiles

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Brain Function Assessment in Learning (BFAL 2020)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 12462))

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Abstract

Herein, we are proposing a novel and radical pipeline that will facilitate the repurposing of approved drugs in an unprecedented way that will eventually yield invaluable insights and results that will aid the pharma-medical domain to tackle many more pathologies using weaponry that has already been approved, is safe for the public, is very rapid relatively to conventional drug design and requires no further significant investment to be made. The ultimate goal is to develop a novel clinical concept and establish a computer-aided pipeline that will facilitate and rationalize the repurposing of approved drugs, orphan drugs and generics. The end result of the described pipeline is a competitive and reliable software that will be made available for the scientific community.

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Authors and Affiliations

  1. Genetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Iera Odos 75 Street, 11855, Athens, Greece

    Dimitrios Vlachakis

  2. Laboratory of Molecular Endocrinology, Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation, Academy of Athens, Soranou Ephessiou Street, 11527, Athens, Greece

    Dimitrios Vlachakis

  3. University Research, Institute of Maternal and Child Health and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Thivon 1 & Papadiamantopoulou Street, 11527, Athens, Greece

    Dimitrios Vlachakis

Authors
  1. Dimitrios Vlachakis
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Correspondence to Dimitrios Vlachakis .

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Editors and Affiliations

  1. Department of Computer Science, University of Montreal, Montreal, QC, Canada

    Claude Frasson

  2. Lab of Medical Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Panagiotis Bamidis

  3. Department of Informatics, Ionian University, Corfu, Greece

    Panagiotis Vlamos

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Vlachakis, D. (2020). Introducing Drugonfly; A Novel Computer-Aided Drug Repurposing Pipeline Based on Genomic, Structural and Physicochemical Profiles. In: Frasson, C., Bamidis, P., Vlamos, P. (eds) Brain Function Assessment in Learning. BFAL 2020. Lecture Notes in Computer Science(), vol 12462. Springer, Cham. https://doi.org/10.1007/978-3-030-60735-7_13

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  • DOI: https://doi.org/10.1007/978-3-030-60735-7_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-60734-0

  • Online ISBN: 978-3-030-60735-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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