Skip to main content

DeSupGAN: Multi-scale Feature Averaging Generative Adversarial Network for Simultaneous De-blurring and Super-Resolution of Retinal Fundus Images

  • Conference paper
  • First Online:
Ophthalmic Medical Image Analysis (OMIA 2020)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12069))

Included in the following conference series:

Abstract

Image quality is of utmost importance for image-based clinical diagnosis. In this paper, a generative adversarial network-based retinal fundus quality enhancement network is proposed. With the advent of different cheaper, affordable and lighter point-of-care imaging or telemedicine devices, the chances of making a better and more accessible healthcare system in developing countries become higher. But these devices often lack the quality of images. This single network simultaneously takes into account two different image degradation problems that are common i.e. blurring and low spatial resolution. A novel convolutional multi-scale feature averaging block (MFAB) is proposed which can extract feature maps with different kernel sizes and fuse them together. Both local and global feature fusion are used to get a stable training of wide network and to learn the hierarchical global features. The results show that this network achieves better results in terms of peak-signal-to-noise ratio (PSNR) and structural similarity index (SSIM) metrics compared with other super-resolution, de-blurring methods. To the best of our knowledge, this is the first work that has combined multiple degradation models simultaneously for retinal fundus images analysis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sengupta, S., Singh, A., Leopold, H.A., Gulati, T., Lakshminarayanan, V.: Ophthalmic diagnosis using deep learning with fundus images-a critical review. Artif. Intell. Med. 10, 101758 (2020)

    Article  Google Scholar 

  2. Panwar, N., Huang, P., Lee, J., Keane, P.A., Chuan, T.S., Richhariya, A., et al.: Fundus photography in the 21st century–a review of recent technological advances and their implications for worldwide healthcare. Telemed. e-Health 22(3), 198–208 (2016)

    Article  Google Scholar 

  3. Das, V., Dandapat, S., Bora, P.K.: A novel diagnostic information based framework for super-resolution of retinal fundus images. Comput. Med. Imaging Graph. 72, 22–33 (2019)

    Article  Google Scholar 

  4. Quellec, G., Bazin, L., Cazuguel, G., Delafoy, I., Cochener, B., Lamard, M.: Suitability of a low-cost, handheld, nonmydriatic retinograph for diabetic retinopathy diagnosis. Transl. Vis. Sci. Technol. 5(2), 16 (2016)

    Article  Google Scholar 

  5. Cuadros, J., Bresnick, G.: Can commercially available handheld retinal cameras effectively screen diabetic retinopathy? J. Diab. Sci. Technol. 11(1), 135–137 (2017)

    Article  Google Scholar 

  6. Barritt, N., Parthasarathy, M.K., Faruq, I., Zelek, J., Lakshminarayanan, V.: Fundus camera versus smartphone camera attachment: image quality analysis. In: Current Developments in Lens Design and Optical Engineering XX, vol. 11104, p. 111040A. International Society for Optics and Photonics (2019)

    Google Scholar 

  7. Fu, H., et al.: Evaluation of retinal image quality assessment networks in different color-spaces. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11764, pp. 48–56. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32239-7_6

    Chapter  Google Scholar 

  8. Shen, Z., Fu, H., Shen, J., Shao, L.: Understanding and correcting low-quality retinal fundus images for clinical analysis. arXiv preprint arXiv:2005.05594 (2020)

  9. Zhou, M., Jin, K., Wang, S., Ye, J., Qian, D.: Color retinal image enhancement based on luminosity and contrast adjustment. IEEE Trans. Biomed. Eng. 65(3), 521–527 (2017)

    Article  Google Scholar 

  10. Mitra, A., Roy, S., Roy, S., Setua, S.K.: Enhancement and restoration of non-uniform illuminated fundus image of retina obtained through thin layer of cataract. Comput. Methods Programs Biomed. 156, 169–178 (2018)

    Article  Google Scholar 

  11. Xiong, L., Li, H., Xu, L.: An enhancement method for color retinal images based on image formation model. Comput. Methods Programs Biomed. 143, 137–150 (2017)

    Article  Google Scholar 

  12. Zhao, H., Yang, B., Cao, L., Li, H.: Data-driven enhancement of blurry retinal images via generative adversarial networks. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11764, pp. 75–83. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32239-7_9

    Chapter  Google Scholar 

  13. Williams, B.M., et al.: Fast blur detection and parametric deconvolution of retinal fundus images. In: Cardoso, M.J., et al. (eds.) FIFI/OMIA -2017. LNCS, vol. 10554, pp. 194–201. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-67561-9_22

    Chapter  Google Scholar 

  14. Mahapatra, D., Bozorgtabar, B., Hewavitharanage, S., Garnavi, R.: Image super resolution using generative adversarial networks and local saliency maps for retinal image analysis. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 382–390. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_44

    Chapter  Google Scholar 

  15. Mahapatra, D., Bozorgtabar, B., Garnavi, R.: Image super-resolution using progressive generative adversarial networks for medical image analysis. Comput. Med. Imaging Graph. 71, 30–39 (2019)

    Article  Google Scholar 

  16. Goodfellow, I., Pouget-Abadie, J., Mirza, M., Xu, B., Warde-Farley, D., Ozair S., et al.: Generative adversarial nets. In: Advances in Neural Information Processing Systems, pp. 2672–2680 (2014)

    Google Scholar 

  17. Johnson, J., Alahi, A., Fei-Fei, L.: Perceptual losses for real-time style transfer and super-resolution. In: Leibe, B., Matas, J., Sebe, N., Welling, M. (eds.) ECCV 2016. LNCS, vol. 9906, pp. 694–711. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46475-6_43

    Chapter  Google Scholar 

  18. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

  19. Decencière, E., Zhang, X., Cazuguel, G., Lay, B., Cochener, B., Trone, C., et al.: Feedback on a publicly distributed image database: the Messidor database. Image Anal. Stereol. 33(3), 231–234 (2014)

    Article  Google Scholar 

  20. Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)

  21. Abadi, M., Agarwal, A., Barham, P., Brevdo, E., Chen, Z., Citro, C., et al.: TensorFlow: large-scale machine learning on heterogeneous systems (2015). Software Available from tensorflow.org

    Google Scholar 

  22. Tai, Y.-W., Tan, P., Brown, M.S.: Richardson-Lucy deblurring for scenes under a projective motion path. IEEE Trans. Pattern Anal. Mach. Intell. 33(8), 1603–1618 (2010)

    Google Scholar 

  23. Ledig, C., Theis, L., Huszár, F., Caballero, J., Cunningham, A., Acosta, A., et al.: Photo-realistic single image super-resolution using a generative adversarial network. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 4681–4690 (2017)

    Google Scholar 

  24. Kupyn, O., Budzan, V., Mykhailych, M., Mishkin, D., Matas, J.: DeblurGAN: blind motion deblurring using conditional adversarial networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 8183–8192 (2018)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sourya Sengupta .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Sengupta, S., Wong, A., Singh, A., Zelek, J., Lakshminarayanan, V. (2020). DeSupGAN: Multi-scale Feature Averaging Generative Adversarial Network for Simultaneous De-blurring and Super-Resolution of Retinal Fundus Images. In: Fu, H., Garvin, M.K., MacGillivray, T., Xu, Y., Zheng, Y. (eds) Ophthalmic Medical Image Analysis. OMIA 2020. Lecture Notes in Computer Science(), vol 12069. Springer, Cham. https://doi.org/10.1007/978-3-030-63419-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-63419-3_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-63418-6

  • Online ISBN: 978-3-030-63419-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics