Abstract
Predicting brain age from Magnetic Resonance Imaging (MRI) can be used to identify neurological disorders at an early stage. The brain contour is a biomarker for the onset of brain-related problems. Artificial Intelligence (AI) based Convolutional Neural Networks (CNN) is used to detect brain-related problems in MRI images. However, conventional CNN is a complex architecture and the time to process the image, large data requirement and overfitting are some of its challenges. This study proposes a transfer learning approach using InceptionV3 to classify brain age from the MRI images in order to improve the brain age classification model. Models are trained on an augmented OASIS (Open Access Series of Imaging Studies) dataset which contains 411 raw and 411 masked MRI images of different people. The models are evaluated using testing accuracy, precision, recall, and F1-Scores. Results demonstrate that InceptionV3 has a testing accuracy of 85%. This result demonstrates the potential for InceptionV3 to be used by medical practitioners to detect brain age and the potential onset of neurological disorders from MRI images.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
- 2.
https://fcon_1000.projects.nitrc.org/indi/enhanced/.
References
Bermudez, C., et al.: Anatomical context improves deep learning on the brain age estimation task. Magn. Reson. Imaging 62, 70–77 (2019)
Besteher, B., Gaser, C. and Nenadić, I.: Machine-learning based brain age estimation in major depression showing no evidence of accelerated aging. Psychiatry Res. Neuroimaging 290, 1–4 (2019)
Chelghoum, R., Ikhlef, A., Hameurlaine, A., Jacquir, S.: Transfer learning using convolutional neural network architectures for brain tumor classification from MRI images. In: Maglogiannis, I., Iliadis, L., Pimenidis, E. (eds.) AIAI 2020. IAICT, vol. 583, pp. 189–200. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-49161-1_17
Ding, Y., et al.: A deep learning model to predict a diagnosis of Alzheimer disease by using 18F-FDG PET of the brain. Radiology 290(2), 456–464 (2019)
Franke, K., Gaser, C., Manor, B., Novak, V.: Advanced brainAGE in older adults with type 2 diabetes mellitus. Front. Aging Neurosci. 5, 90 (2013)
Gaser, C., Franke, K., Klöppel, S., Koutsouleris, N., Sauer, H.: BrainAGE in mild cognitive impaired patients: Predicting the conversion to Alzheimer’s disease, PLoS ONE 8(6), e67346 (2013)
Huang, G., Liu, Z., Van Der Maaten, L., Weinberger, K.Q.: Densely connected convolutional networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 4700–4708 (2017)
Huang, T.-W.: Age estimation from brain MRI images using deep learning. In: 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017), pp. 849–852. IEEE (2017)
Marcus, D.S., Fotenos, A.F., Csernansky, J.G., Morris, J.C., Buckner, R.L.: Open access series of imaging studies: longitudinal MRI data in nondemented and demented older adults. J. Cogn. Neurosci. 22(12), 2677–2684 (2010)
Mikolajczyk, A., Grochowski, M.: Data augmentation for improving deep learning in image classification problem. In: 2018 International Interdisciplinary Ph.D. Workshop (IIPhDW), pp. 117–122. IEEE (2018)
Nakano, R., et al.: Neonatal brain age estimation using manifold learning regression analysis. In: 2015 IEEE International Conference on Systems, Man, and Cybernetics, pp. 2273–2276. IEEE (2015)
Qi, Q., Du, B., Zhuang, M., Huang, Y., Ding, X.: Age estimation from MR images via 3D convolutional neural network and densely connect. In: Cheng, L., Leung, A.C.S., Ozawa, S. (eds.) ICONIP 2018. LNCS, vol. 11307, pp. 410–419. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-04239-4_37
Ren, Y., Luo, Q., Gong, W., Lu, W.: Transfer learning models on brain age prediction. In: Proceedings of the Third International Symposium on Image Computing and Digital Medicine, pp. 278–282 (2019)
Shao, L., Zhu, F., Li, X.: Transfer learning for visual categorization: a survey. IEEE Trans. Neural Netw. Learn. Syst. 26(5), 1019–1034 (2014)
Siar, M., Teshnehlab, M.: Age detection from brain MRI images using the deep learning. In: 2019 9th International Conference on Computer and Knowledge Engineering (ICCKE), pp. 369–374. IEEE (2019)
Ueda, M., et al.: An age estimation method using 3D-CNN from brain MRI images. In: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), pp. 380–383. IEEE (2019)
Wang, J.: Gray matter age prediction as a biomarker for risk of dementia. Proc. Natl. Acad. Sci. 116(42), 21213–21218 (2019)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Kumar, A., Pathak, P., Stynes, P. (2020). A Transfer Learning Approach to Classify the Brain Age from MRI Images. In: Bellatreche, L., Goyal, V., Fujita, H., Mondal, A., Reddy, P.K. (eds) Big Data Analytics. BDA 2020. Lecture Notes in Computer Science(), vol 12581. Springer, Cham. https://doi.org/10.1007/978-3-030-66665-1_8
Download citation
DOI: https://doi.org/10.1007/978-3-030-66665-1_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-66664-4
Online ISBN: 978-3-030-66665-1
eBook Packages: Computer ScienceComputer Science (R0)