Abstract
Currently, leukocyte detection has the problem of scarcity of labeled samples, so a focal dataset must be expanded by merging multiple datasets. At the same time, given the difference in the dyeing methods, dyeing time, and collection techniques, some datasets have the problem of different homology distributions. Moreover, the effect of direct training after dataset merging is not satisfactory. The morphology of the leukocyte types is also variable and stain contamination occurs, thereby leading to the misjudgment of using traditional convolutional networks. Therefore, in this paper, the model parameter-transfer method is used to alleviate the problem of less leukocyte labeled data in the training model and deformable convolution is introduced into the main network of target detection to improve the accuracy of the object detection model. First, numerous leukocyte datasets are used to train the blood leukocyte binary classification detection network, and the model parameters of the blood leukocyte binary classification detection network are transferred to the blood leukocyte multi classification detection network through the transfer of model parameters. This method can make better use of datasets of the same origin and different distributions so as to solve the problem of scarcity in blood leukocyte data sets. Finally, the multi classification detection network is trained quickly and the accurate blood leukocyte detection results are obtained through fine tuning. The experimental results show that compare our method with the traditional Faster RCNN object detection algorithm, \({mAP}_{0.5}\) is 0.056 higher, \({mAP}_{0.7}\) is 0.119 higher, with higher recall by 4%, and better accuracy by 5%. Thus, the method proposed in this paper can achieve highly accurate leukocyte detection.
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References
Nakanishi, N., et al.: White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men. Diabetologia 45(1), 42–48 (2002). https://doi.org/10.1007/s125-002-8243-1
李海波. 血常规检验中各项指标的意义. 世界最新医学信息文摘 16(42), 110–111 (2016)
AL-Dulaimi, K., et al.: Classification of blood leukocytes types from microscope images: techniques and challenges. In: Microscopy Science: Last Approaches on Educational Programs and Applied Research, vol. 8. Formatex Research Center (2018)
Rawat, J., et al.: Review of leukocyte classification techniques for microscopic blood images. In: 2015 2nd International Conference on Computing for Sustainable Global Development (INDIACom). IEEE (2015)
Mahmood, N.H., Lim, P.C., Mazalan, S.M., Azhar, M., Razak, A.: Blood cells extraction using color based segmentation technique. Int. J. Life Sci. Biotechnol. Pharma Res. 2(2), 2250–3137 (2013)
Huang, D.-C., Hung, K.-D., Chan, Y.-K.: A computer assisted method for leukocyte nucleus segmentation and recognition in blood smear images. J. Syst. Softw. 85(9), 2104–2118 (2012)
Price, A.L., et al.: Principal components analysis corrects for stratification in genome-wide association studies. Nature Genet. 38(8), 904–909 (2006)
Wang, W., Su, P.: Blood cell image segmentation on color and GVF Snake for Leukocyte classification on SVM. Opt. Precis. Eng. 12, 26 (2012)
Pan, C., et al.: Leukocyte image segmentation by visual attention and extreme learning machine. Neural Comput. Appl. 21(6), 1217–1227 (2012)
Huang, G.-B., Zhu, Q.-Y., Siew, C.-K.: Extreme learning machine: theory and applications. Neurocomputing 70(1–3), 489–501 (2006)
Tabrizi, P.R., Rezatofighi, S.H., Yazdanpanah, M.J.: Using PCA and LVQ neural network for automatic recognition of five types of blood leukocytes. In: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology. IEEE (2010)
Liu, J., et al.: Nonwoven uniformity identification using wavelet texture analysis and LVQ neural network. Expert Syst. Appl. 37(3), 2241–2246 (2010)
Lecun, Y., Bengio, Y., Hinton, G.: Deep learning. Nature 521(7553), 436 (2015)
Liu, L., et al.: Deep learning for generic object detection: a survey. arXiv preprint arXiv: 1809.02165 (2018)
Shirazi, S.H., et al.: Efficient leukocyte segmentation and recognition in peripheral blood image . Technol. Health Care 24(3), 335–347 (2016)
Qin, F., et al.: Fine-grained leukocyte classification with deep residual learning for microscopic images Comput. Methods Programs Biomed. 162, 243–252 (2018)
Zhao, J., et al.: Automatic detection and classification of leukocytes using convolutional neural networks. Med. Biol. Eng. Comput. 55(8), 1287–1301 (2017)
Torrey, L., Shavlik, J.: Transfer learning. In: Handbook of Research on Machine Learning Applications and Trends: Algorithms, Methods, and Techniques, pp. 242–264. IGI Global (2010)
Sinno, J.P., Yang, Q.: A survey on transfer learning. IEEE Educational Activities Department (2010)
Dai, J., et al.: Deformable convolutional networks. In: Proceedings of the IEEE International Conference on Computer Vision (2017)
Girshick, R., et al.: Rich feature hierarchies for accurate object detection and semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (2014)
Uijlings, J.R.R., et al.: Selective search for object recognition. Int. J. Comput. Vis. 104(2), 154–171 (2013). https://doi.org/10.1007/s11263-013-0620-5
Dai, J., et al.: R-FCN: object detection via region-based fully convolutional networks. In: Advances in Neural Information Processing Systems (2016)
Gribbon, K.T., Bailey, D.G.: A novel approach to real-time bilinear interpolation. In: Proceedings DELTA 2004. Second IEEE International Workshop on Electronic Design, Test and Applications. IEEE (2004)
He, K., Zhang, X., Ren, S., et al.: Deep Residual Learning for Image Recognition (2015)
Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)
Ren, S., He, K., Girshick, R., et al.: Faster R-CNN: towards real-time object detection with region proposal networks. IEEE Trans. Pattern Anal. Mach. Intell. 39(6), 1137–1149 (2017)
Neubeck, A., Gool, L.J.V.: Efficient non-maximum suppression. In: International Conference on Pattern Recognition. IEEE Computer Society (2006)
Rezatofighi, S.H., Soltanian-Zadeh, H.: Comput. Med. Imaging Graph. 35, 333 (2011)
Liu, W., et al.: SSD: single shot multibox detector. In: Leibe, B., Matas, J., Sebe, N., Welling, M. (eds.) Computer Vision – ECCV 2016: 14th European Conference, Amsterdam, The Netherlands, October 11–14, 2016, Proceedings, Part I, pp. 21–37. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46448-0_2
Acknowledgments
This work is supported by the National Natural Science Foundation of China (NSFC) under Grant 61972187, the Scientific Research Project of Science and Education Park Development Center of Fuzhou University, Jinjiang under Grant 2019-JJFDKY-53 and the Tianjin University-Fuzhou University Joint Fund under Grant TF2020-6.
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Chen, K., Wei, W., Zhong, S., Guo, L. (2021). Blood Leukocyte Object Detection According to Model Parameter-Transfer and Deformable Convolution. In: Zhang, Y., Xu, Y., Tian, H. (eds) Parallel and Distributed Computing, Applications and Technologies. PDCAT 2020. Lecture Notes in Computer Science(), vol 12606. Springer, Cham. https://doi.org/10.1007/978-3-030-69244-5_1
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