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Non-invasive Optical Methods in Quantitative Minimal Erythema Dose Assessment in Vivo: Comparison of Preclinical and Clinical Data

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Biomedical Engineering Systems and Technologies (BIOSTEC 2020)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1400))

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Abstract

Even in modern dermatology clinics, the determination of the severity of ultraviolet (UV)-induced erythema and assessment of individual photosensitivity based on the calculation of minimal erythema dose (MED) is still performed visually, which is subjective, and associated with high variability of the results and frequent errors when it done be untrained personnel. The application of non-invasive quantitaitve methods such as laser fluorescence spectroscopy (LFS) and optical tissue oximetry (OTO) could be a solution of these problems. In is well known that acute UV skin damage is associated with structural alterations, vasodilatation and inflammatory response. Moreover, porphyrins which have well-known autofluorescent properties play a role in the chemoattraction of immune cells to the area of local inflammation caused by UV. Using LFS in the preclinical part of the study on ICR mice (N = 25) time-dependent dynamic changes in the fluorescence parameters of porphyrins were found. Optical parameters were in a good agreement with histological findings. Statistically significant correlation was found between the severity of inflammatory infiltrate and the tissue content index (η) of porphyrins. During the clinical part of the study on healthy volunteers (n = 14) the analysis of endogenous fluorescence and microcirculation characteristics by LFS and OTO revealed the correlation relationship between the intensity of endogenous fluorescence of porphyrins and oxygen consumption with a dose of UV radiation. The correlation of the porphyrins fluorescence with a dose of UV was also demonstrated. Overall results have fundamental value and should be investigated and applied in clinical practice to objectively assess and predict MED.

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Authors and Affiliations

  1. Moscow Regional Research and Clinical Institute “MONIKI”, 61/2, Shchepkina Street, 129110, Moscow, RF, Russia

    Mikhail Makmatov-Rys, Irina Raznitsyna, Dmitriy Kulikov, Alexey Glazkov, Anton Molochkov, Daria Mosalskaya, Maksim Bobrov, Alexey Sekirin & Dmitry Rogatkin

  2. Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198, Moscow, RF, Russia

    Anton Molochkov & Marina Gureeva

  3. Cosmetological Clinic «Lemark», 32 Vladimir Nevsky Street, 394088, Voronezh, RF, Russia

    Ekaterina Kaznacheeva

Authors
  1. Mikhail Makmatov-Rys
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Editor information

Editors and Affiliations

  1. Zhejiang University, Hangzhou, China

    Xuesong Ye

  2. Fraunhofer Portugal Research Center for Assistive Information and Communication Solutions, Porto, Portugal

    Filipe Soares

  3. Nice Sophia Antipolis University, Nice Cedex 2, France

    Elisabetta De Maria

  4. Universidad Politécnica de Madrid, Madrid, Spain

    Pedro Gómez Vilda

  5. University of Milano-Bicocca, Milan, Italy

    Federico Cabitza

  6. Instituto de Telecomunicações, University of Lisbon, Lisbon, Portugal

    Ana Fred

  7. Universidade Nova de Lisboa, Caparica, Portugal

    Hugo Gamboa

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Makmatov-Rys, M. et al. (2021). Non-invasive Optical Methods in Quantitative Minimal Erythema Dose Assessment in Vivo: Comparison of Preclinical and Clinical Data. In: Ye, X., et al. Biomedical Engineering Systems and Technologies. BIOSTEC 2020. Communications in Computer and Information Science, vol 1400. Springer, Cham. https://doi.org/10.1007/978-3-030-72379-8_5

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  • DOI: https://doi.org/10.1007/978-3-030-72379-8_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-72378-1

  • Online ISBN: 978-3-030-72379-8

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