Abstract
Imaging of cerebral aneurysms using DSA, MRI or CTA plays a key role in diagnosis, decision for treatment or observation, treatment planning either as microsurgical clipping or as endovascular intervention including filling of the aneurysm with coils, implantation of flow diverter in the parent vessel or filling the aneurysm with liquid embolic agents. Additionally, imaging is used in long-term follow-up of treated and untreated aneurysms. Imaging tasks and challenges include detection of aneurysms especially of aneurysms smaller than 3 mm, accurate quantitative analysis of geometric parameters assessing size and shape necessary for rupture risk assessment as well as treatment decision and eventually the type of treatment. Finally, image-based computational fluid dynamics analysis of hemodynamic risk parameters requires accurate segmentation and reconstruction of anatomical structures. These objectives motivated us to initiate the Cerebral Aneurysm Detection and Analysis (CADA) challenge. It is based on datasets of 3D rotational angiographies, the “gold standard” for clinical management of cerebral aneurysms. Datasets stem from patients with unruptured and ruptured aneurysms.
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References
Keedy, A.: An overview of intracranial aneurysms. McGill J. Med. 9, 141–146 (2006)
Jeong, Y.-G., Jung, Y.-T., Kim, M.-S., Eun, C.-K., Jang, S.-H.: Size and location of ruptured intracranial aneurysms. J. Korean Neurosurg. Soc. 45, 11–15 (2009)
Thompson, B.G., Brown, R.D., Amin-Hanjani, S., et al.: Guidelines for the management of patients with unruptured intracranial aneurysms: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke 46, 2368–2400 (2015)
Brisman, J.L., Song, J.K., Newell, D.W.: Cerebral aneurysms. N. Engl. J. Med. 355, 928–939 (2006)
Vlak, M.H.M., Algra, A., Brandenburg, R.J.E., Rinkel, G.J.: Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol. 10, 626–636 (2011)
Suarez, J., Tarr, R.W., Selman, W.R.: Aneurysmal subarachnoid hemorrhage. N. Engl. J. Med. 354, 387–396 (2006)
Steiner, T., Juvela, S., Unterberg, A., et al.: European stroke organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc. Dis. 35, 93–112 (2013)
Wiebers, D.O., Whisnant, J.P., Huston, J., Meissner, I., Brown, R.D., Piepgras, D.G., et al.: Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362, 103–110 (2003)
Morita, A., Kirino, T., Hashi, K., et al.: The natural course of unruptured cerebral aneurysms in a Japanese cohort. N. Engl. J. Med. 366, 2474–2482 (2012)
Mokin, M., Waqas, M., Gong, A., et al.: What size cerebral aneurysms rupture? A systematic review and meta-analysis of literature. Neurosurgery 66(1), 145–146 (2019)
Beck, J., Rhode, S., Berkefeld, J., et al.: Size and location of ruptured and unruptured intracranial aneurysms measured by 3-dimensional rotational angiography. Surg. Neurol. 65, 18–25 (2006)
Clarke, M.: Systematic review of reviews of risk factors for intracranial aneurysms. Neuroradiology 50, 653–664 (2008)
Greving, J.P., Wermer, M.J.H., Brown, R.D., et al.: Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol. 13, 59–66 (2014)
Backes, D., Vergouwen, M.D.I., Tiel Groenestege, A.T., et al.: PHASES score for prediction of intracranial aneurysm growth. Stroke 46, 1221–1226 (2015)
Bijlenga, P., Gondar, R., Schilling, S., et al.: PHASES score for the management of intracranial aneurysm: a cross-sectional population-based retrospective study. Stroke 48, 2105–2112 (2017)
Darsaut, T., Fahed, R., Raymond, J.: PHASES and the natural history of unruptured aneurysms: science or pseudoscience? J Neurointerv. Surg. 9, 527–528 (2017)
Howard, B.M., Hu, R., Barrow, J.W., et al.: Comprehensive review of imaging of intracranial aneurysms and angiographically negative subarachnoid hemorrhage. Neurosurg. Focus 47, 1–3 (2019)
Goubergrits, L., et al.: Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH) - uncertainty quantification of geometric rupture risk parameters. Biomed. Eng. Online 18, 35 (2019)
Goubergrits, L., Schaller, J., Kertzscher, U., Woelken, Th., Ringelstein, M., Spuler, A.: Hemodynamic impact of cerebral aneurysm endovascular treatment devices: coils and flow diverters. Expert Rev. Med. Devices 11, 361–373 (2014)
Xiang, J., Yu, J., Choi, H., Dolan Fox, J.M., et al.: Rupture resemblance score (RRS): toward risk stratification of unruptured intracranial aneurysms using hemodynamic-morphological discriminants. J Neurointerv Surg. 7, 490–495 (2015)
Dhar, S., Tremmel, M., Mocco, J., et al.: Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery 63, 185–196 (2008)
Xiang, J., Natarajan, S.K., Tremmel, M., et al.: Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 42, 144–152 (2011)
Cebral, J.R., Mut, F., Weir, J., et al.: Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. Am. J. Neuroradiol. 32, 145–151 (2011)
Jou, L.D., Lee, D.H., Morsi, H., et al.: Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery. Am. J. Neuroradiol. 29, 1761–1767 (2008)
Dammert, S., Krings, T., Moller-Hartmann, W., et al.: Detection of intracranial aneurysms with multislice CT: comparison with conventional angiography. Neuroradiology 46, 427–434 (2004)
Thompson, B.G., et al.: Guidelines for the management of patients with unruptured intracranial aneurysms. Stroke 46, 2368–2400 (2015)
Wang, H., Li, W., He, H., et al.: 320-Detector row CT angiography for detection and evaluation of intracranial aneurysms: comparison with conventional digital subtraction angiography. Clin. Radiol. 68, e15–e20 (2013)
Chappell, E.T., Moure, F.C., Good, M.C.: Comparison of computed tomographic angiography with digital subtraction angiography in the diagnosis of cerebral aneurysms: a meta-analysis. Neurosurgery 52, 624–631 (2003)
Li, M.H., Cheng, Y.S., Li, Y.D., et al.: Large-cohort comparison between three-dimensional time-of-flight magnetic resonance and rotational digital subtraction angiographies in intracranial aneurysm detection. Stroke 40, 3127–3129 (2009)
Agid, R., Schaaf, M., Farb, R.: CE-MRA for follow-up of aneurysms post stent-assisted coiling. Interv. Neuroradiol. 18, 275–283 (2012)
Hacein-Bey, L., Provenzale, J.M.: Current imaging assessment and treatment of intracranial aneurysms. AJR 196, 32–44 (2011)
Lasheras, J.C.: The biomechanics of arterial aneurysms. Annu. Rev. Fluid Mech. 39, 293–319 (2007)
Heros, R.C., Morcos, J.J.: Cerebrovascular surgery: past, present, and future. Neurosurgery 47, 1007–1033 (2000)
Polevaya, N.V., Kalani, M.Y.S., Steinberg, G.K., et al.: The transition from hunterian ligation to intracranial aneurysm clips: a historical perspective. Neurosurg. Focus 20, 1–7 (2006)
Darsaut, T.E., Bing, F., Salazkin, I., et al.: Testing flow diverters in giant fusiform aneurysms: a new experimental model can show leaks responsible for failures. AJNR Am. J. Neuroradiol. 32, 2175–2179 (2011)
Augsburger, L., Reymond, P., Rufenacht, D.A., et al.: Intracranial stents being modeled as a porous medium: flow simulation in stented cerebral aneurysms. Ann. Biomed. Eng. 39, 850–863 (2011)
Lanzino, G., Kanaan, Y., Perrini, P., et al.: Emerging concepts in the treatment of intracranial aneurysms: stents, coated coils, and liquid embolic agents. Neurosurgery 57, 449–459 (2005)
Brilstra, E.H., Rinkel, G.J., van der Graaf, Y., et al.: Treatment of intracranial aneurysms by embolization with coils: a systematic review. Stroke 30, 470–476 (1999)
David, C.A., Vishteh, A.G., Spetzler, R.F., et al.: Late angiographic follow-up review of surgically treated aneurysms. J. Neurosurg. 91, 396–401 (1999)
Brown, M.A., Parish, J., Guandique, C.F., et al.: A long-term study of durability and risk factors for aneurysm recurrence after microsurgical clip ligation. J. Neurosurg. 126, 819–824 (2017)
Colby, G.P., Paul, A.R., Radvany, M.G., et al.: A single center comparison of coiling versus stent assisted coiling in 90 consecutive paraophthalmic region aneurysm. J. Neurointerv. Surg. 4, 116–120 (2012)
Campos, J.K., Cheaney Ii, B., Lien, B.V., et al.: Advances in endovascular aneurysm management: flow modulation techniques with braided mesh devices. Stroke Vasc. Neurol. 5, 1–3 (2020)
Burkhardt, J.-K., Chua, M.H.J., Miriam Weiss, M., et al.: Risk of aneurysm residual regrowth, recurrence, and de novo aneurysm formation after microsurgical clip occlusion based on follow-up with catheter angiography. World Neurosurg. 106, 74–84 (2017)
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Spuler, A., Goubergrits, L. (2021). CADA: Clinical Background and Motivation. In: Hennemuth, A., Goubergrits, L., Ivantsits, M., Kuhnigk, JM. (eds) Cerebral Aneurysm Detection and Analysis. CADA 2020. Lecture Notes in Computer Science(), vol 12643. Springer, Cham. https://doi.org/10.1007/978-3-030-72862-5_2
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DOI: https://doi.org/10.1007/978-3-030-72862-5_2
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