Abstract
The great achievements of molecular biology theory have had a great impact on human epistemology, way of thinking and social development. This research mainly discusses the application of computer molecular biology technology in the field of clinical microbiological examination. Use a high-throughput sequencing platform for actual measurement. According to the sample information, select appropriate reagents and methods to extract the total nucleic acid (total RNA) in the sample and store it for later use. Nucleic acid is randomly interrupted, that is, nucleic acid molecules are fragmented. It can be purified by ultrasonic fragmentation method, enzyme digestion method, etc. Using RNA molecules as templates, adding primers required for reverse transcription, constructing a suitable PCR reaction system, and gradually synthesizing the first and second cDNA strands. Add the sample and a series of reaction reagents to the reaction system, set the parameters, and run the sequencer for sequencing. Then conduct bioinformatics analysis,. when the virus mutation rate is 10%, all analysis procedures can calculate a relatively high coverage of the viral pathogen genome. This research contributes to the promotion of computer molecular biology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gao, S., Song, S., Cheng, J.: Incorporation of solvent effect into multi-objective evolutionary algorithm for improved protein structure prediction. IEEE/ACM Trans. Comput. Biol. Bioinf. 15(4), 1365–1378 (2018)
Bhattacharjee, P., Mitra, P.: A survey of density based clustering algorithms. Front. Comput. Sci. 15(1), 1–27 (2021)
Khan, Y.D., Rasool, N., Hussain, W.: Iphosy-pseaac: identify phosphotyrosine sites by incorporating sequence statistical moments into pseaac. Mol. Biol. Rep. 45(6), 2501–2509 (2018)
Levin, M., Bongard, J., Lunshof, J.E.: Applications and ethics of computer-designed organisms. Nat. Rev. Mol. Cell Biol. 21(11), 1–2 (2020)
Yamasaki, S., Amemiya, T., Yabuki, Y.: Togo-WF: prediction of RNA tertiary structures and RNA–RNA/protein interactions using the KNIME workflow. J. Comput. Aided Mol. Des. 33(5), 497–507 (2019)
Breuer, M., Ananthanarayanan, V.: Cell scientist to watch -Vaishnavi Ananthanarayanan. J. Cell Sci. 132(11), 1–2 (2019)
Acuna, V.V., Hopper, R.M., Yoder, R.J.: Computer-aided drug design for the organic chemistry laboratory using accessible molecular modeling tools. J. Chem. Educ. 97(3), 760–763 (2020)
Khedr, A.M., Ibrahim, M.H.: LPB: a new decoding algorithm for improving the performance of an HMM In gene finding application. IAENG Int. J. Comput. Sci. 47(4), 4–13 (2020)
Khan, T., Ahmad, R., Azad, I., Raza, S., Joshi, S., Khan, A.R.: Computer-aided drug design and virtual screening of targeted combinatorial libraries of mixed-ligand transition metal complexes of 2-butanone thiosemicarbazone. Computat. Biol. Chem. 75(4), 178–195 (2018)
Zhao, Z., Zhang, W., Che, W.: An evaluation of chinese human-computer dialogue technology. Data Intell. 1(2), 187–200 (2019)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Liu, Y., Sun, H., Dong, X. (2021). Computer Molecular Biology Technology in the Field of Clinical Microbiological Examination. In: Abawajy, J., Xu, Z., Atiquzzaman, M., Zhang, X. (eds) 2021 International Conference on Applications and Techniques in Cyber Intelligence. ATCI 2021. Advances in Intelligent Systems and Computing, vol 1398. Springer, Cham. https://doi.org/10.1007/978-3-030-79200-8_55
Download citation
DOI: https://doi.org/10.1007/978-3-030-79200-8_55
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-79199-5
Online ISBN: 978-3-030-79200-8
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)