Abstract
To study the mechanism of Cistanche deserticola in the treatment of colorectal cancer by network pharmacology. Methods: The chemical constituents of Cistanche deserticola and the related targets were screened by TCMSP. Gene Cards, OMIM, PharmGkb, GrugBank, and TTD databases were used to screen colorectal cancer-related targets. The network of “active components-targets” was constructed and the common targets were chosen as potentially therapeutic. The GO function enrichment analysis and KEGG pathway analysis were carried out for the target screening by the R package cluster profiler. Finally, Auto dock Vina was used to realize the molecular docking of core components and key targets. Results: There were 6 active compounds and 154 potential targets for Cistanche deserticola; 12877 targets for Colorectal cancer were obtained. There were 149 intersecting targets, which were enriched in multiple malignancies including colorectal cancer pathways. Conclusion: This study provides a scientific basis for explicating the potential of Cistanche deserticola in the treatment of colorectal cancer and establishing a foundation for further investigation of the role of its active components in cancer drug design.
Y. Dong, C. Xu and C. Ren—Contributed to the work equally.
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Dong, Y. et al. (2021). Study on the Mechanism of Cistanche in the Treatment of Colorectal Cancer Based on Network Pharmacology. In: Huang, DS., Jo, KH., Li, J., Gribova, V., Premaratne, P. (eds) Intelligent Computing Theories and Application. ICIC 2021. Lecture Notes in Computer Science(), vol 12838. Springer, Cham. https://doi.org/10.1007/978-3-030-84532-2_22
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