Abstract
Golgi proteins are encapsulated in membrane system. The main function of the Golgi is to process, sort, and transport proteins, synthesized by the endoplasmic reticulum, and then to be sorted into specific parts of the cell or secreted outside the cell. The Golgi apparatus is the site for the final processing and packaging of cell secretions, such as proteins. In this paper, we use Deep Forest to classify 2 different types of protein by 406 features. Deep Forest achieves more simply and more efficient process compared to traditional KNN classifier.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Marengo, A., Rosso, C., Bugianesi, E.: Liver cancer: connections with obesity, fatty liver, and cirrhosis. Annu. Rev. Med. 67, 103–117 (2016)
Altekruse, S.F., McGlynn, K.A., Reichman, M.E.: Hepatocellular carcinoma incidence, mortality, and survival trends in the united states from 1975 to 2005. J. Clin. Oncol. 27, 1485–1491 (2009)
Choi, J.M., et al.: HepG2 cells as an in vitro model for evaluation of cytochrome p450 induction by xenobiotics. Arch. Pharm. Res. 38, 691–704 (2015)
Jantamat, P., Weerapreeyakul, N., Puthongking, P.: Cytotoxicity and apoptosis induction of Coumarins and Carbazole alkaloids from Clausena harmandiana. Molecules 24, 3385 (2019)
Wang, L., et al.: Trilobatin, a novel SGLT1/2 inhibitor, selectively induces the proliferation of human hepatoblastoma cells. Molecules 24, 3390 (2019)
Weng, Z.B., et al.: Positive skeletal effect of two ingredients of Psoralea corylifolia I. on estrogen deficiency-induced osteoporosis and the possible mechanisms of action. Mol. Cell Endocrinol. 417, 103–113 (2015)
Haraguchi, H., Inoue, J., Tamura, Y., Mizutani, K.: Antioxidative components of Psoralea corylifolia (Leguminosae). Phytother. Res. PTR 16, 539–544 (2002)
Wu, C., Sun, Z., Ye, Y., Han, X., Song, X., Liu, S.: Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia 91, 205–210 (2013)
Bera, T.K., Ali, K.M., Jana, K., Ghosh, A., Ghosh, D.: Protective effect of aqueous extract of seed of Psoralea corylifolia (Somraji) and seed of Trigonella foenum-graecum l. (methi) in streptozotocin-induced diabetic rat: a comparative evaluation. Pharmacogn. Res. 5, 277–285 (2013)
Li, H.N., Wang, C.Y., Wang, C.L., Chou, C.H., Leu, Y.L., Chen, B.Y.: Antimicrobial effects and mechanisms of ethanol extracts of psoralea corylifolia seeds against listeria monocytogenes and methicillin-resistant staphylococcus aureus. Foodborne Pathog. Dis. 16, 573–580 (2019)
Latha, P.G., Evans, D.A., Panikkar, K.R., Jayavardhanan, K.K.: Immunomodulatory and antitumour properties of Psoralea corylifolia seeds. Fitoterapia 71, 223–231 (2000)
Zhang, Z., Zhang, W., Ji, Y.P., Zhao, Y., Wang, C.G., Hu, J.F.: Gynostemosides ae, megastigmane glycosides from gynostemma pentaphyllum. Phytochemistry 71, 693–700 (2010)
Bapat, K., et al.: Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent. Appl. Radiat. Isotopes 62, 389–393 (2005)
Chen, Z., et al.: Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma a549 cell line. Eur. J. Pharmacol. 643, 170–179 (2010)
Han, Y., Xu, B.L., Guo, Y.H.: A novel chaetomugilin from cullen corylifolium (l.) medik. Lat. Am. J. Pharm. 38, 7 (2019)
Chopra, B., Dhingra, A.K., Dhar, K.L.: Psoralea corylifolia l. (Buguchi) - folklore to modern evidence: review. Fitoterapia 90, 44–56 (2013)
Lu, H., Zhang, L., Liu, D., Tang, P., Song, F.: Isolation and purification of Psoralen and Isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr. Health Sci. 14, 641–647 (2014)
Wang, X., et al.: Effects of Psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells. Biol. Pharm. Bull. 39, 815–822 (2016)
Wu, D., et al.: Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica 103, 1472–1483 (2018)
Marx, D., et al.: Differential expression of apoptosis associated genes bax and bcl-2 in ovarian cancer. Anticancer Res. 17, 2233–2240 (1997)
Knudson, C.M., Korsmeyer, S.J.: Bcl-2 and bax function independently to regulate cell death. Nat. Genet. 16, 358–363 (1997)
Du, L., Fei, Z., Song, S., Wei, N.: Antitumor activity of lobaplatin against esophageal squamous cell carcinoma through caspase-dependent apoptosis and increasing the bax/bcl-2 ratio. Biomed. Pharmacother. 95, 447–452 (2017)
Stepien, A., Izdebska, M., Grzanka, A.: The types of cell death. Postepy Hig. Med. Dosw. 61, 420–428 (2007)
Joseph, E.K., Levine, J.D.: Caspase signalling in neuropathic and inflammatory pain in the rat. Eur. J. Neurosci. 20, 2896–2902 (2004)
Peng, X., Zhang, Y.Y., Wang, J., Ji, Q.: Ethylacetate extract from tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells. Tumor Biol. 37, 865–876 (2016)
Acknowledgement
This work was supported by the Natural Science Foundation of China (No. 61902337), Natural Science Fund for Colleges and Universities in Jiangsu Province (No. 19KJB520016), Jiangsu Provincial Natural Science Foundation (No. SBK2019040953), Young talents of science and technology in Jiangsu and the Xuzhou Science and Technology Plan Funded Project - Research on Key Technologies for Three-dimensional Monitoring of Lake Water Environment Based on 5G Internet of Things (KC19208).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this paper
Cite this paper
Yao, Y., Gu, Y., Bao, W., Zhang, L., Zhu, Y. (2021). Golgi Protein Prediction with Deep Forest. In: Huang, DS., Jo, KH., Li, J., Gribova, V., Premaratne, P. (eds) Intelligent Computing Theories and Application. ICIC 2021. Lecture Notes in Computer Science(), vol 12838. Springer, Cham. https://doi.org/10.1007/978-3-030-84532-2_58
Download citation
DOI: https://doi.org/10.1007/978-3-030-84532-2_58
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-84531-5
Online ISBN: 978-3-030-84532-2
eBook Packages: Computer ScienceComputer Science (R0)