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Toward an Intelligent Computing Solution for Endotracheal Obstruction Prediction in COVID-19 Patients in ICU

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Advances in Computational Intelligence (IWANN 2021)

Abstract

Nowadays there is a world pandemic of a challenging respiratory illness, COVID-19. A large part of COVID-19 patients evolves to severe or fatal complications and require an ICU admission. COVID-19 mortality rate approaches 30% due to complications such as obstruction of the trachea and bronchi of patients during the ICU stay.

An endotracheal obstruction occurring during any moment in a COVID-19 patient ICU stay is one of the most complicated situations that clinicians must face and solve. Therefore, it is very important to know in advance when a COVID-19 patient could enter in the pre-obstruction zone.

In this work we present an intelligent computing solution to predict endotracheal obstruction for COVID-19 patients in ICU. It is called the Binomial Gate LSTM (BigLSTM), a new and innovative deep modular neural architecture based on the recurrent neural network LSTM. Its main feature is its ability to handle missing data and to deal with time series with no regular sample frequency. These are the main characteristics of the BigLSTM information environment. This ability is implemented in BigLSTM by an information redundancy injection mechanism and how it copes with time control.

We applied BigLSTM with first wave COVID-19 patients in ICU of Complejo Hospitalario Universitario Insular Materno Infantil. Encouraging results, even while working with a very small data set, indicate that our developed computing solution is going forwards towards an efficient intelligent prediction system which is very appropriate for this kind of problem.

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References

  1. Ferrando, C., et al.: Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: a prospective, cohort, multicentre study. Rev. Esp. Anestesiol. Reanim. 67(8), 425–437 (2020)

    Article  CAS  Google Scholar 

  2. Hochreiter, S., Schmidhuber, J.: Long short-term memory. Neural Comput. 9, 1735–1780 (1997). https://doi.org/10.1162/neco.1997.9.8.1735

    Article  CAS  PubMed  Google Scholar 

  3. Suykens, J.A.K., Van Gestel, T., De Brabanter, J., De Moor, B., Vandewalle, J.: Least Squares Support Vector Machines. World Scientific Pub. Co., Singapore (2002)

    Book  Google Scholar 

  4. Cho, K., et al.: Learning Phrase Representations using RNN Encoder-Decoder for Statistical Machine Translation (2014). eprint arXiv:1406.1078

  5. Che, Z., Purushotham, S., Cho, K., et al.: Recurrent neural networks for multivariate time series with missing values. Sci. Rep. 8, 6085 (2018)

    Article  Google Scholar 

  6. Sammut, C., Webb, G.I.: Leave-one-out cross-validation. In: Sammut, C., Webb G.I. (eds) Encyclopedia of Machine Learning. Springer, Boston, MA (2011). https://doi.org/10.1007/978-0-387-30164-8_469

  7. Pham, T., Brochard, L.J., Slutsky, A.S.: Mechanical Ventilation: State of the Art. Mayo Clinic Proc. 92(9), 1382–1400 (2017). https://doi.org/10.1016/j.mayocp.2017.05.004

    Article  Google Scholar 

  8. Silva, P.L., Pelosi, P., Rocco, P.R.M.: Optimal mechanical ventilation strategies to minimize ventilator-induced lung injury in non-injured and injured lungs. Expert Rev. Resp. Med. 10(12), 1243–1245 (2016)

    Article  CAS  Google Scholar 

  9. MacIntyre, N.R.: Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American college of chest physicians the American association for respiratory care and the American college of critical medicine. Chest. 120(6), 375–395 (2001). https://doi.org/10.1378/chest.120.6_suppl.375s

    Article  Google Scholar 

  10. ICU Care Manager Software | Patient Care Unit System | Picis. https://www.picis.com/en/solution/clinical-information-system-suite/critical-care-manager/. Accessed 25 Apr 2021

  11. Kandel, E.: In search of memory: the emergence of a new science of mind. FASEB J. 20, 1043–1044 (2006). https://doi.org/10.1096/fj.06-0604ufm

    Article  CAS  Google Scholar 

  12. Chariker, L., Shapley, R., Young, L.-S.: Rhythm and synchrony in a cortical network model. J. Neurosci. 38(40), 8621–8634 (2018)

    Article  CAS  Google Scholar 

  13. Sharkey, A.J.C. (ed.): Combining Artificial Neural Nets: Ensemble and Modular Multi-Net Systems. Springer Science & Business Media, Heidelberg (2012)

    Google Scholar 

  14. Hochreiter, S., Schmidhuber, J.: LSTM can solve hard long time lag problems. In: Mozer, M.C., Jordan, M.I., Petsche, T. (eds.) Advances in Neural Information Processing Systems 9 (NIPS 9), pp. 473–479. MIT Press, Cambridge (1997)

    Google Scholar 

  15. Hochreiter, S., Bengio, Y., Frasconi, P., Schmidhuber, J.: Gradient flow in recurrent nets: the difficulty of learning long-term dependencies. In: Kremer, S.C., Kolen, J.F. (eds.) A Field Guide to Dynamical Recurrent Neural Neworks. IEEE Press (2001)

    Google Scholar 

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Acknowledgement

This research work has been funded by the University of Las Palmas de Gran Canaria, through the project COVID 19–11, “Aplicación de técnicas de machine learning para la detección temprana de obstrucción del tubo endotracheal en pacientes COVID-19 en UCI”.

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Correspondence to Carmen Paz Suárez-Araujo .

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Fernández-López, P. et al. (2021). Toward an Intelligent Computing Solution for Endotracheal Obstruction Prediction in COVID-19 Patients in ICU. In: Rojas, I., Joya, G., Català, A. (eds) Advances in Computational Intelligence. IWANN 2021. Lecture Notes in Computer Science(), vol 12861. Springer, Cham. https://doi.org/10.1007/978-3-030-85030-2_6

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  • DOI: https://doi.org/10.1007/978-3-030-85030-2_6

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-85030-2

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