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Benchmarking of Shallow Learning and Deep Learning Techniques with Transfer Learning for Neurodegenerative Disease Assessment Through Handwriting

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Document Analysis and Recognition – ICDAR 2021 Workshops (ICDAR 2021)

Abstract

Neurodegenerative diseases are incurable diseases where a timely diagnosis plays a key role. For this reason, various techniques of computer aided diagnosis (CAD) have been proposed. In particular handwriting is a well-established diagnosis technique. For this reason, an analysis of state-of-the-art technologies, compared to those which historically proved to be effective for diagnosis, remains of primary importance. In this paper a benchmark between shallow learning techniques and deep neural network techniques with transfer learning are provided: their performance is compared to that of classical methods in order to quantitatively estimate the possibility of performing advanced assessment of neurodegenerative disease through both offline and online handwriting. Moreover, a further analysis of their performance on the subset of a new dataset, which makes use of standardized handwriting tasks, is provided to determine the impact of the various benchmarked techniques and draw new research directions.

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References

  1. Impedovo, D., Pirlo, G.: Dynamic handwriting analysis for the assessment of neurodegenerative diseases: a pattern recognition perspective. IEEE Rev. Biomed. Eng. 12, 209–220 (2019)

    Article  Google Scholar 

  2. De Stefano, C., Fontanella, F., Impedovo, D., Pirlo, G., di Freca, A.S.: Handwriting analysis to support neurodegenerative diseases diagnosis: a review. Pattern Recogn. Lett. 121, 37–45 (2018)

    Article  Google Scholar 

  3. Rosenblum, S., Samuel, M., Zlotnik, S., Erikh, I., Schlesinger, I.: Handwriting as an objective tool for Parkinson’s disease diagnosis. J. Neurol. 260(9), 2357–2361 (2013)

    Article  Google Scholar 

  4. Astrom, F., Koker, R.: A parallel neural network approach to prediction of Parkinson’s Disease. Expert Syst. Appl. 38(10), 12470–12474 (2011)

    Article  Google Scholar 

  5. O’Reilly, C., Plamondon, R.: Development of a sigma–lognormal representation for on-line signatures. Pattern Recogn. 42(12), 3324–3337 (2009)

    Article  Google Scholar 

  6. Pereira, C.R., et al.: A step towards the automated diagnosis of Parkinson’s disease: analyzing handwriting movements. In: IEEE 28th International Symposium on Computer Based Medical Systems (CBMS), pp. 171–176 (2015)

    Google Scholar 

  7. Kahindo, C., El-Yacoubi, M.A., Garcia-Salicetti, S., Rigaud, A., Cristancho-Lacroix, V.: Characterizing early-stage alzheimer through spatiotemporal dynamics of handwriting. IEEE Signal Process. Lett. 25(8), 1136–1140 (2018)

    Article  Google Scholar 

  8. Caligiuri, M.P., Teulings, H.L., Filoteo, J.V., Song, D., Lohr, J.B.: Quantitative measurement of handwriting in the assessment of drug-induced Parkinsonism. Hum. Mov. Sci. 25(4), 510–522 (2006)

    Article  Google Scholar 

  9. Drotár, P., Mekyska, J., Rektorová, I., Masarová, L., Smékal, Z., Faun-dez-Zanuy, M.: Decision support framework for Parkinson’s disease based on novel handwriting markers. IEEE Trans. Neural Syst. Rehabil. Eng. 23(3), 508–516 (2015)

    Article  Google Scholar 

  10. Ponsen, M.M., Daffertshofer, A., Wolters, E.C., Beek, P.J., Berendse, H.W.: Impairment of complex upper limb motor function in de novo Parkinson’s disease. Parkinsonism Related Disord. 14(3), 199–204 (2008)

    Article  Google Scholar 

  11. Smits, E.J., et al.: Standardized handwriting to assess bradykinesia, micrographia and tremor in Parkinson’s disease. PLOS One 9(5), e97614 (2014)

    Google Scholar 

  12. Broderick, M.P., Van Gemmert, A.W., Shill, H.A.: Hypometria and bradykinesia during drawing movements in individuals with Parkinson disease. Exp. Brain Res. 197(3), 223–233 (2009)

    Article  Google Scholar 

  13. Kotsavasiloglou, C., Kostikis, N., Hristu-Varsakelis, D., Arnaoutoglou, M.: Machine learning-based classification of simple drawing movements in Parkinson’s disease. Biomed. Signal Process. Control 31, 174–180 (2017)

    Article  Google Scholar 

  14. Li, G., et al.: Temperature based restricted Boltzmann Machines. Sci. Rep. 6, Article no. 19133 (2016)

    Google Scholar 

  15. Impedovo, D.: Velocity-based signal features for the assessment of Parkinsonian handwriting. IEEE Signal Process. Lett. 26(4), 632–636 (2019)

    Article  Google Scholar 

  16. Rao, K.R., Yip, P.: Discrete Cosine Transform: Algorithms, Advantages. Applications. Academic press, New York (2014)

    MATH  Google Scholar 

  17. Breiman, L.: Random forests. Mach. Learn. 45(1), 5–32 (2001)

    Article  Google Scholar 

  18. Baraniuk, R.G.: Compressive sensing [lecture notes]. IEEE Signal Process. Mag. 24, 118–121 (2007)

    Article  Google Scholar 

  19. Reitan, R.M.: Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual Motor Skills 8(3), 271–276 (1958)

    Article  Google Scholar 

  20. Tan, C., Sun, F., Kong, T., Zhang, W., Yang, C., Liu, C.: A survey on deep transfer learning. In: International Conference on Artificial Neural Networks, pp. 270–279. Springer, Cham (2018)

    Google Scholar 

  21. Deng, J., Dong, W., Socher, R., Li, L.J., Li, K., Fei-Fei, L.: Imagenet: a large-scale hierarchical image database. In: 2009 IEEE Conference on Computer Vision and Pattern Recognition, pp. 248–255. IEEE, June 2009

    Google Scholar 

  22. Chollet, F.: Keras. Keras documentation: Keras Applications. Keras.io (2020). https://keras.io/api/applications/. Accessed 30 Oct 2020

  23. Zoph, B., Vasudevan, V., Shlens, J., Le, Q.V.: Learning transferable architectures for scalable image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 8697–8710 (2018)

    Google Scholar 

  24. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  25. Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., Wojna, Z.: Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2818–2826 (2016)

    Google Scholar 

  26. Szegedy, C., Ioffe, S., Vanhoucke, V., Alemi, A.: Inception-v4, inception-resnet and the impact of residual connections on learning. arXiv preprint arXiv:1602.07261 (2016)

  27. Liwicki, M., Graves, A., Fernàndez, S., Bunke, H., Schmidhuber, J.: In Proceedings of the 9th International Conference on Document Analysis and Recognition, ICDAR 2007 (2007)

    Google Scholar 

  28. Bahdanau, D., Cho, K., Bengio, Y.: Neural machine translation by jointly learning to align and translate. arXiv preprint arXiv:1409.0473 (2014)

  29. Pereira, C.R., Weber, S.A., Hook, C., Rosa, G.H., Papa, J.P.: Deep learning-aided Parkinson's disease diagnosis from handwritten dynamics. In: 2016 29th SIBGRAPI Conference on Graphics, Patterns and Images (SIBGRAPI), pp. 340–346. IEEE, October 2016

    Google Scholar 

  30. Isenkul, M., Sakar, B., Kursun, O.: Improved spiral test using digitized graphics tablet for monitoring Parkinson’s disease. In: Proceedings of the International Conference on e-Health and Telemedicine, pp. 171–175, May 2014

    Google Scholar 

  31. Impedovo, D., et al.: Writing generation model for health care neuromuscular system investigation. In: International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, pp. 137–148. Springer, Cham, June 2013

    Google Scholar 

  32. Likforman-Sulem, L., Esposito, A., Faundez-Zanuy, M., Clémençon, S., Cordasco, G.: EMOTHAW: a novel database for emotional state recognition from handwriting and drawing. IEEE Trans. Hum. Mach. Syst. 47(2), 273–284 (2017)

    Article  Google Scholar 

  33. Diaz, M., Ferrer, M.A., Impedovo, D., Pirlo, G., Vessio, G.: Dynamically enhanced static handwriting representation for Parkinson’s disease detection. Pattern Recogn. Lett. 128, 204–210 (2019)

    Article  Google Scholar 

  34. Impedovo, D., Pirlo, G., Vessio, G., Angelillo, M.T.: A handwriting-based protocol for assessing neurodegenerative dementia. Cognit. Comput. 11(4), 576–586 (2019)

    Article  Google Scholar 

  35. Puigcerver, J.: Are multidimensional recurrent layers really necessary for handwritten text recognition? In: 2017 14th IAPR International Conference on Document Analysis and Recognition (ICDAR), vol. 1, pp. 67–72. IEEE, November 2017

    Google Scholar 

  36. Doetsch, P., Zeyer, A., Ney, H.: Bidirectional decoder networks for attention-based end-to-end offline handwriting recognition. In: 2016 15th International Conference on Frontiers in Handwriting Recognition (ICFHR), pp. 361–366. IEEE, October 2016

    Google Scholar 

  37. Dentamaro, V., Impedovo, D., Pirlo, G.: Gait analysis for early neurodegenerative diseases classification through the Kinematic Theory of Rapid Human Movements. IEEE Access (2020)

    Google Scholar 

  38. Dentamaro, V., Impedovo, D., Pirlo, G.: Sit-to-stand test for neurodegenerative diseases video classification. In: International Conference on Pattern Recognition and Artificial Intelligence, pp. 596–609. Springer, Cham, October 2020

    Google Scholar 

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Correspondence to Donato Impedovo .

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Dentamaro, V., Giglio, P., Impedovo, D., Pirlo, G. (2021). Benchmarking of Shallow Learning and Deep Learning Techniques with Transfer Learning for Neurodegenerative Disease Assessment Through Handwriting. In: Barney Smith, E.H., Pal, U. (eds) Document Analysis and Recognition – ICDAR 2021 Workshops. ICDAR 2021. Lecture Notes in Computer Science(), vol 12917. Springer, Cham. https://doi.org/10.1007/978-3-030-86159-9_1

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  • DOI: https://doi.org/10.1007/978-3-030-86159-9_1

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