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Carbon Monoxide Effect on Human Cardiac Tissue. In Silico Study

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Applied Computer Sciences in Engineering (WEA 2021)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1431))

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Abstract

The Exposure to atmospheric pollutants, such as carbon monoxide (CO), promotes the appearance of cardiovascular diseases. Studies have shown that CO blocks calcium channels, leading to a decrease of the ICaL current and to a shortening of the action potential duration (APD); favoring the generation of cardiac arrhythmias. The aim of this work is to study the CO effects, at different concentrations, on the atrial and ventricular tissues using computational simulations. An equation of the CO effect on ICaL was developed. It was included in two mathematical models of human atrial and ventricular cells, under normal physiological conditions. Atrial and ventricular 2D models were developed to evaluate the CO effect on the generation of reentries as an arrhythmogenic mechanism. The results show that CO blocks the ICaL current in a greater fraction as its concentration increases, causing APD shortening. Such effect is larger in atrial cardiomycytes. Arrhythmic events (rotors) were generated at the high CO concentration in atrial tissue. In ventricular tissue it was not possible to generate rotors. This study provides a first step in investigating the proarrhythmic effects of CO in healthy people.

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Acknowledgment

This work was supported by the Ministerio de Ciencia Tecnología e Innovación (MINCIENCIAS) from Colombia, through grant No. 120677757994. The work of Durango-Giraldo was supported by the “Convocatoria para el fortalecimiento de proyectos en ejecución de CTeI en ciencias de la salud con talento joven e impacto regional” of MINCIENCIAS.

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Authors and Affiliations

  1. MATBIOM, Universidad de Medellín, Medellín, Colombia

    Catalina Tobón & Geraldine Durango-Giraldo

  2. GIMSC, Universidad de San Buenaventura, Medellín, Colombia

    Juan Pablo Ugarte

Authors
  1. Catalina Tobón
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  2. Geraldine Durango-Giraldo
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  3. Juan Pablo Ugarte
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Corresponding author

Correspondence to Catalina Tobón .

Editor information

Editors and Affiliations

  1. Universidad Distrital Francisco José de Caldas, Bogotá, Colombia

    Juan Carlos Figueroa-García

  2. Universidad Santo Tomás de Aquino, Bogotá, Colombia

    Yesid Díaz-Gutierrez

  3. Universidad Distrital Francisco José de Caldas, Bogotá, Colombia

    Elvis Eduardo Gaona-García

  4. Universidad del Rosario, Bogotá, Colombia

    Alvaro David Orjuela-Cañón

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Tobón, C., Durango-Giraldo, G., Ugarte, J.P. (2021). Carbon Monoxide Effect on Human Cardiac Tissue. In Silico Study. In: Figueroa-García, J.C., Díaz-Gutierrez, Y., Gaona-García, E.E., Orjuela-Cañón, A.D. (eds) Applied Computer Sciences in Engineering. WEA 2021. Communications in Computer and Information Science, vol 1431. Springer, Cham. https://doi.org/10.1007/978-3-030-86702-7_14

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  • DOI: https://doi.org/10.1007/978-3-030-86702-7_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-86701-0

  • Online ISBN: 978-3-030-86702-7

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