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Adjacent Scale Fusion and Corneal Position Embedding for Corneal Ulcer Segmentation

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Ophthalmic Medical Image Analysis (OMIA 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12970))

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Abstract

Corneal ulcer segmentation from fluorescein staining images is vital for objective and quantitative assessments of ocular surface damages. How to utilize prior information from the fluorescein staining images is a challenge. In this work, we propose and validate a novel method for corneal ulcer segmentation. Leveraging Adjacent Scale Fusion and Corneal Position Embedding, our method can effectively capture fine patterns of the corneal ulcer as well as explicitly characterize the discriminating relative position information within the cornea. We evaluate the corneal ulcer segmentation performance of our method on a publicly-accessible SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers, with a mean Dice similarity coefficient of 80.73% and a mean Jaccard Index of 71.63% having been obtained. Quantitative results identify the superiority of the proposed method over representative state-of-the-art deep learning frameworks. In addition, the importance of each key component in the proposed method is analyzed both quantitatively and qualitatively.

Z. Wang and J. Lyu contributed equally to this work.

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References

  1. Whitcher, J.P., Srinivasan, M., Upadhyay, M.P.: Corneal blindness: a global perspective. Bull. World Health Organ. 79, 214–221 (2001)

    Google Scholar 

  2. Bron, A.J., et al.: Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop. Ocular Surface 5(2), 108–152 (2007)

    Article  Google Scholar 

  3. Diamond, J., et al.: Corneal biopsy with tissue micro homogenisation for isolation of organisms in bacterial keratitis. Eye 13(4), 545 (1999)

    Article  Google Scholar 

  4. Joyce, P.D.: Corneal vital staining. Ir. J. Med. Sci. (1926-1967) 42(8), 359–367 (1967). https://doi.org/10.1007/BF02954080

    Article  Google Scholar 

  5. Passmore, J.W., King, J.H.: Vital staining of conjunctiva and cornea: review of literature and critical study of certain dyes. A.M.A. Arch. Ophthalmol. 53(4), 568–574 (1955)

    Article  Google Scholar 

  6. Van Bijsterveld, O.P.: Diagnostic tests in the sicca syndrome. Arch. Ophthalmol. 82(1), 10–14 (1969)

    Article  Google Scholar 

  7. Olsson, C., Thelin, S., Stahle, E.: Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002. J. Vasc. Surg. 46(3), 609 (2007)

    Article  Google Scholar 

  8. Bron, A.J., Evans, V.E., Smith, J.A.: Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea 22(7), 640–650 (2003)

    Article  Google Scholar 

  9. Peterson, R.C., Wolffsohn, J.S.: Objective grading of the anterior eye. Optom. Vis. Sci. 86(3), 273–278 (2009)

    Article  Google Scholar 

  10. Chun, Y.S., Yoon, W.B., Kim, K.G., Park, I.K.: Objective assessment of corneal staining using digital image analysis. Investig. Ophthalmol. Vis. Sci. 55(12), 7896–7903 (2014)

    Article  Google Scholar 

  11. Deng, L., Huang, H., Yuan, J., Tang, X.: Superpixel based automatic segmentation of corneal ulcers from ocular staining images. In: IEEE 23rd International Conference on Digital Signal Processing, pp. 1–5 (2018)

    Google Scholar 

  12. Fu, H., et al.: Joint optic disc and cup segmentation based on multi-label deep network and polar transformation. IEEE Trans. Med. Imaging 37(7), 1597–1605 (2018)

    Article  Google Scholar 

  13. Gu, Z., et al.: CE-Net: context encoder network for 2d medical image segmentation. IEEE Trans. Med. Imaging 38(10), 2281–2292 (2019)

    Article  Google Scholar 

  14. Huang, Y., et al.: Automated hemorrhage detection from coarsely annotated fundus images in diabetic retinopathy. In: IEEE 17th International Symposium on Biomedical Imaging, pp. 1369–1372 (2020)

    Google Scholar 

  15. Deng, L., et al.: The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers. Sci. Data 7(1), 1–7 (2020)

    Article  Google Scholar 

  16. Tao, A., Sapra, K., Catanzaro, B.: Hierarchical multi-scale attention for semantic segmentation. arXiv preprint arXiv:2005.10821 (2020)

  17. Xu, R., Wang, X., Chen, K., Zhou, B., Loy, CC.: Positional encoding as spatial inductive bias in GANs. arXiv preprint arXiv:2012.05217 (2020)

  18. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

  19. Zhou, Z., Rahman Siddiquee, M.M., Tajbakhsh, N., Liang, J.: UNet++: a nested U-Net architecture for medical image segmentation. In: Stoyanov, D., et al. (eds.) DLMIA/ML-CDS 2018. LNCS, vol. 11045, pp. 3–11. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00889-5_1

    Chapter  Google Scholar 

  20. Lin, T.Y., et al.: Feature pyramid networks for object detection. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2117–2125 (2017)

    Google Scholar 

  21. Zhao, H., Shi, J., Qi, X., Wang, X., Jia, J.: Pyramid scene parsing network. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2881–2890 (2017)

    Google Scholar 

  22. Chen, LC., Papandreou, G., Schroff, F., Adam, H.: Rethinking atrous convolution for semantic image segmentation. arXiv preprint arXiv:1706.05587 (2017)

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Correspondence to Xiaoying Tang .

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Wang, Z., Lyu, J., Luo, W., Tang, X. (2021). Adjacent Scale Fusion and Corneal Position Embedding for Corneal Ulcer Segmentation. In: Fu, H., Garvin, M.K., MacGillivray, T., Xu, Y., Zheng, Y. (eds) Ophthalmic Medical Image Analysis. OMIA 2021. Lecture Notes in Computer Science(), vol 12970. Springer, Cham. https://doi.org/10.1007/978-3-030-87000-3_1

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  • DOI: https://doi.org/10.1007/978-3-030-87000-3_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-86999-1

  • Online ISBN: 978-3-030-87000-3

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