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MetaHistoSeg: A Python Framework for Meta Learning in Histopathology Image Segmentation

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Deep Generative Models, and Data Augmentation, Labelling, and Imperfections (DGM4MICCAI 2021, DALI 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 13003))

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Abstract

Few-shot learning is a standard practice in most deep learning based histopathology image segmentation, given the relatively low number of digitized slides that are generally available. While many models have been developed for domain specific histopathology image segmentation, cross-domain generalization remains a key challenge for properly validating models. Here, tooling and datasets to benchmark model performance across histopathological domains are lacking. To address this limitation, we introduce MetaHistoSeg – a Python framework that implements unique scenarios in both meta learning and instance based transfer learning. Designed for easy extension to customized datasets and task sampling schemes, the framework empowers researchers with the ability of rapid model design and experimentation. We also curate a histopathology meta dataset - a benchmark dataset for training and validating models on out-of-distribution performance across a range of cancer types. In experiments we showcase the usage of MetaHistoSeg with the meta dataset and find that both meta-learning and instance based transfer learning deliver comparable results on average, but in some cases tasks can greatly benefit from one over the other.

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References

  1. Xing, F., Xie, Y., Yang, L.: An automatic learning-based framework for robust nucleus segmentation. IEEE Trans. Med. Imaging 1(1), 99 (2015)

    Google Scholar 

  2. Al-Milaji et al.: Segmentation of tumor into epithelial vs. stromal regions. In: CONFERENCE 2016, LNCS, vol. 9999, pp. 1–13. Springer, Heidelberg (2017)

    Google Scholar 

  3. Manivannan, A., et al.: Segmented the glandular structures by combining the handcrafted multi-scale image features and features computed by a deep convolutional network. Med. Image Comput. Comput. Assist Interv. 16(2), 411–8 (2013)

    Google Scholar 

  4. Chan, L., et al.: HistoSegNet: histological tissue type exocrine gland endocrine gland. Transp. Vessel. Med. Image Comput. Comput. Assist Interv. 16(2), 411–8 (2013)

    Google Scholar 

  5. Nir, G., Hor, S., Karimi, D., Fazli, L., et al.: Automatic grading of prostate cancer in digitized histopathology images: learning from multiple experts. Med. Image Anal. 1(50), 167–80 (2018)

    Article  Google Scholar 

  6. Peikari, M., Salama, S., et al.: Automatic cellularity assessment from post-treated breast surgical specimens. Cytom. Part A 91(11), 1078–1087 (2017)

    Google Scholar 

  7. Kumar, N., Verma, R., Sharma, S., et al.: A dataset and a technique for generalized nuclear segmentation for computational pathology. IEEE Trans. Med. Imaging 36(7), 1550–1560 (2017)

    Google Scholar 

  8. Sirinukunwattana, K., Snead, D.R.J., Rajpoot, N.M.: A stochastic polygons model for glandular structures in colon histology images. IEEE Trans. Med. Imaging 34(11), 2366–2378 (2015). https://doi.org/10.1109/TMI.2015.2433900

  9. Li, J., et al.: Signet ring cell detection with a semi-supervised learning framework. In: Chung, A.C.S., Gee, J.C., Yushkevich, P.A., Bao, S. (eds.) IPMI 2019. LNCS, vol. 11492, pp. 842–854. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-20351-1_66

    Chapter  Google Scholar 

  10. American Cancer Society: Cancer Facts and Figures 2020. AmericanCancer Society, Atlanta, Ga (2020)

    Google Scholar 

  11. Finn, C., Abbeel, P., Levine, S.: Model-agnostic meta-learning for fast adaptation of deep networks. In: Proceedings of the International Conference of Machine Learning (2017)

    Google Scholar 

  12. Mishra, N., Rohaninejad, M., et al.: A simple neural attentive metalearner. In: Proceedings of the International Conference on Learning Representations (2018)

    Google Scholar 

  13. Munkhdalai, T., Yu, H.: Meta networks. In: Proceedings of the International Conference on Machine Learning, pp. 2554–2563 (2017)

    Google Scholar 

  14. Beare, R., Lowekamp, B., Yaniv, Z.: Image segmentation, registration and characterization in R with SimpleITK. J. Stat. Softw. 86(8) (2018)

    Google Scholar 

  15. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

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Correspondence to Zheng Yuan .

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Yuan, Z., Esteva, A., Xu, R. (2021). MetaHistoSeg: A Python Framework for Meta Learning in Histopathology Image Segmentation. In: Engelhardt, S., et al. Deep Generative Models, and Data Augmentation, Labelling, and Imperfections. DGM4MICCAI DALI 2021 2021. Lecture Notes in Computer Science(), vol 13003. Springer, Cham. https://doi.org/10.1007/978-3-030-88210-5_27

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  • DOI: https://doi.org/10.1007/978-3-030-88210-5_27

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-88209-9

  • Online ISBN: 978-3-030-88210-5

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