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Spirometry-Based Airways Disease Simulation and Recognition Using Machine Learning Approaches

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Learning and Intelligent Optimization (LION 2021)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 12931))

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Abstract

The purpose of this study is to provide means to physicians for automated and fast recognition of airways diseases. In this work, we mainly focus on measures that can be easily recorded using a spirometer. The signals used in this framework are simulated using the linear bi-compartment model of the lungs. This allows us to simulate ventilation under the hypothesis of ventilation at rest (tidal breathing). By changing the resistive and elastic parameters, data samples are realized simulating healthy, fibrosis and asthma breathing. On this synthetic data, different machine learning models are tested and their performance is assessed. All but the Naive bias classifier show accuracy of at least 99%. This represents a proof of concept that Machine Learning can accurately differentiate diseases based on manufactured spirometry data. This paves the way for further developments on the topic, notably testing the model on real data.

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References

  1. Otis, A.B., et al.: Mechanical factors in distribution of pulmonary ventilation. J. Appl. Physiol. 8(4), 427–443 (1956)

    Google Scholar 

  2. Hao, L., et al.: Dynamic characteristics of a mechanical ventilation system with spontaneous breathing. IEEE Access 7, 172847–172859 (2019). https://doi.org/10.1109/ACCESS.2019.2955075

  3. Bodduluri, S., et al.: Deep neural network analyses of spirometry for structural phenotyping of chronic obstructive pulmonary disease. JCI Insight 5(13) (2020). https://doi.org/10.1172/jci.insight.132781

  4. Breiman, L.: Random forests. Technical Report (2001)

    Google Scholar 

  5. Di Dio, R.: Analyzing movement patterns to facilitate the titration of medications in late stage parkinson’s disease. Master’s thesis, Politecnico di Torino (2019)

    Google Scholar 

  6. Domingos, P., Pazzani, M.: On the optimality of the simple Bayesian classifier under zero-one loss. Mach. Learn. 29(2), 103–130 (1997). https://doi.org/10.1023/A:1007413511361

  7. Weibel, E.R.: Geometry and dimensions of airways of conductive and transitory zones. In: Morphometry of the Human Lung, Springer, Berlin (1963)

    Google Scholar 

  8. Philip, M., et al.: Diagnosis of cystic fibrosis: consensus guidelines from the cystic fibrosis foundation. J. pediatr. 181, S4–S15 (2017). https://doi.org/10.1016/j.jpeds.2016.09.064

  9. Gonem, S.: Applications of artificial intelligence and machine learning in respiratory medicine. Thorax 75(8), 695–701 (2020). https://doi.org/10.1136/thoraxjnl-2020-214556

  10. Hofmann, T., Schölkopf, B., Smola, A.J.: Kernel methods in machine learning. Ann. Statist. 36(3), 1171–1220 (2008). https://doi.org/10.1214/009053607000000677

  11. Pfitzner, J.: Poiseuille and his law. Anaesthesia 31(2), 273–275 (1976). https://doi.org/10.1111/j.1365-2044.1976.tb11804.x

  12. Horsfield, K., Cumming, G.: Morphology of the bronchial tree in man. J. Appl. Physiol. 24(3), 373–383 (1968)

    Google Scholar 

  13. Mauroy, B., Filoche, M., Weibel, E.R., Sapoval, B.: An Optimal Bronchial tree may be dangerous. Nature 427(6975), 633–636. https://doi.org/10.1038/nature02287

  14. Tawhai, M.H., Hunter, P., Tschirren, J., Reinhardt, J., McLennan, G., Hoffman, E.A.: Ct-based geometry analysis and finite element models of the human and ovine bronchial tree. J. Appl. Physiol. 97(6), 2310–2321 (2004)

    Google Scholar 

  15. Schulz, H.: Pattern Recognition and Machine Learning (2011)

    Google Scholar 

  16. Scikit learn documentation - logistic regression. https://scikit-learn.org/stable/modules/linear_model.html#logistic-regression

  17. Scikit learn documentation - perceptron. https://scikit-learn.org/stable/modules/linear_model.html#perceptron

  18. Bates, T., Jaspm, H.: Lung Mechanics, an inverse modeling approach. Cambridge University Press, Cambridge (2009)

    Google Scholar 

  19. Raschka, S.: Python Machine Learning. Packt, Maharashtra (2018)

    Google Scholar 

  20. Wang, Y., Hu, M., Li, Q., Zhang, X.P., Zhai, G., Yao, N.: Abnormal respiratory patterns classifier may contribute to large-scale screening of people infected with COVID-19 in an accurate and unobtrusive manner (2020)

    Google Scholar 

  21. Weibel, E.R.: The Pathway for Oxygen. Harvard University Press, Cambridge (1984)

    Google Scholar 

  22. Zhang, H.: The optimality of naive Bayes. In: Technical report (2004). www.aaai.org

Download references

Acknowledgements

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Curie grant agreement No 847581 and is co-funded by the Région SUD Provence-Alpes-Côte d’Azur and IDEX UCA JEDI.

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Di Dio, R., Galligo, A., Mantzaflaris, A., Mauroy, B. (2021). Spirometry-Based Airways Disease Simulation and Recognition Using Machine Learning Approaches. In: Simos, D.E., Pardalos, P.M., Kotsireas, I.S. (eds) Learning and Intelligent Optimization. LION 2021. Lecture Notes in Computer Science(), vol 12931. Springer, Cham. https://doi.org/10.1007/978-3-030-92121-7_8

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  • DOI: https://doi.org/10.1007/978-3-030-92121-7_8

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-92121-7

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