Abstract
The antimicrobial resistance (AMR) crisis is referred to as ‘Medical Climate Crisis’. Inappropriate use of antimicrobial drugs is driving the resistance evolution in pathogenic microorganisms. In 2014 it was estimated that by 2050 more people will die due to antimicrobial resistance compared to cancer. It will cause a reduction of 2% to 3.5% in Gross Domestic Product (GDP) and cost the world up to 100 trillion USD. The indiscriminate use of antibiotics for COVID-19 patients has accelerated the resistance rate. COVID-19 reduced the window of opportunity for the fight against AMR. This man-made crisis can only be averted through accurate actionable antibiotic knowledge, usage, and a knowledge driven Resistomics. In this paper, we present the 2AI (Artificial Intelligence and Augmented Intelligence) and 7D (right Diagnosis, right Disease-causing-agent, right Drug, right Dose, right Duration, right Documentation, and De-escalation) model of antibiotic stewardship. The resistance related integrated knowledge of resistomics is stored as a knowledge graph in a Neo4j properties graph database for 24 × 7 access. This actionable knowledge is made available through smartphones and the Web as a Progressive Web Applications (PWA). The 2AI&7D Model delivers the right knowledge at the right time to the specialists and non-specialist alike at the point-of-action (Stewardship committee, Smart Clinic, and Smart Hospital) and then delivers the actionable accurate knowledge to the healthcare provider at the point-of-care in realtime.
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References
Morrill, H.J., Caffrey, A.R., Jump, R.L.P., Dosa, D., LaPlante, K.L.: Antimicrobial stewardship in long-term care facilities: a call to action. J. Am. Med. Direct. Assoc. 17(2), 183.e1–183.e16 (2016). https://doi.org/10.1016/j.jamda.2015.11.013
O’Neill, J.: Antimicrobial resistance: tackling a crisis for the health and wealth of nations. https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations_1.pdf. (2014)
Could Efforts to Fight the Coronavirus Lead to Overuse of Antibiotics? (2021) https://www.pewtrusts.org/en/research-and-analysis/issue-briefs/2021/03/could-efforts-to-fight-the-coronavirus-lead-to-overuse-of-antibiotics
Talukder, A.K., Schriml, L., Ghosh, A., Biswas, R., Chakrabarti, P., Haas, R.E.: Diseasomics: Actionable Machine Interpretable Disease Knowledge at the Point-of-Care, Submitted (2021)
Talukder, A.K., Haas, R.E.: AIoT: AI meets IoT and web in smart healthcare. In: 13th ACM Web Science Conference 2021 (WebSci ’21 Companion), June 21–25, 2021, Virtual Event, United Kingdom (2021)
Joseph, J., Rodvold, K.A.: The role of carbapenems in the treatment of severe nosocomial respiratory tract infections. Expert Opin. Pharmacother. 9(4), 561–575 (2008). https://doi.org/10.1517/14656566.9.4.561.PMID:18312158
Wikipedia. https://en.wikipedia.org/wiki/Antimicrobial_stewardship
Kuper, K.M., Nagel, J.L., Kile, J.W., May, L.S., Lee, F.M.: The role of electronic health record and “add-on” clinical decision support systems to enhance antimicrobial stewardship programs. Infect. Control Hosp. Epidemiol. 40(5), 501–511 (2019). https://doi.org/10.1017/ice.2019.51. Epub 2019 Apr 25. PMID: 31020944
Dengb, J.L.S., Zhang, L.: A review of artificial intelligence applications for antimicrobial resistance. Biosafety and Health (Available online 11 August 2020) (2020)
Divala, T.H., et al.: Accuracy and consequences of using trial-of-antibiotics for TB diagnosis (ACT-TB study): protocol for a randomised controlled clinical trial. BMJ Open 10(3), e033999 (2020). https://doi.org/10.1136/bmjopen-2019-033999.PMID:32217561;PMCID:PMC7170647,(2020)
Cyriac, J.M., James, E.: Switch over from intravenous to oral therapy: a concise overview. J. Pharmacol. Pharmacother. 5(2), 83–87 (2014). https://doi.org/10.4103/0976-500X.130042
Chang, Y., et al.: Clinical pattern of antibiotic overuse and misuse in primary healthcare hospitals in the southwest of China. PLoS ONE 14(6), e0214779 (2019). https://doi.org/10.1371/journal.pone.0214779
Institute of Medicine: Crossing the Quality Chasm: A New Health System for the 21st Century. National Academy Press, Washington, D.C. (2001)
WHO Collaborating Centre. https://www.whocc.no/atc_ddd_index/
Timo, J.T. Koski, J.N.: A review of bayesian networks and structure learning. 40(1), 51–103 (2012)
Sethi, T., Maheshwari, S., Nagori, A., Lodha, R.: Stewarding antibiotic stewardship in intensive care units with Bayesian artificial intelligence [version 1; referees: awaiting peer review], Welcome Open Research 2018, 3:73 Last updated: 18 JUN 2018 (2018)
Antibiotic Resiatance dataset. https://msberends.github.io/AMR/articles/datasets.html
Grover, A., Leskovec, J.: node2vec: Scalable feature learning for networks. 2016. Knowledge Discovery and Data Mining (2016)
Scutari, M.: Learning Bayesian networks with the bnlearn R package. J. Stat. Softw. 35(3), 1–22 (2010)
Su, C., Andrew, A., Karagas M.R., Borsuk, M.E.: Using Bayesian networks to discover relations between genes, environment, and disease. BioData Mining 6, 6. (2013)
Pearl, J.: The Do-Calculus revisited. In: de Freitas, N., Murphy, K. (eds.), Proceedings of the Twenty-Eighth Conference on Uncertainty in Artificial Intelligence, Corvallis, OR, AUAI Press, 4–11 (2012)
Bakhit, M., Hoffmann, T., Scott, A.M., et al.: Resistance decay in individuals after antibiotic exposure in primary care: a systematic review and meta-analysis. BMC Med 16, 126 (2018)
Berends, M.S., Luz., C.F, Friedrich, A.W., Sinha, B.N.M., Albers, C.J., Glasner, C.: AMR - An R package for working with antimicrobial resistance data. bioRxiv (2019). https://doi.org/10.1101/810622
MetaMap. https://metamap.nlm.nih.gov/
Talukder, A.K., Sanz, J.B., Samajpati, J.: ‘Precision health’: balancing reactive care and proactive care through the evidence based knowledge graph constructed from real-world electronic health records, disease trajectories, diseasome, and patholome. In: Bellatreche, L., Goyal, V., Fujita, H., Mondal, A., Reddy, P.K. (eds.) BDA 2020. LNCS, vol. 12581, pp. 113–133. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-66665-1_9
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Talukder, A.K., Chakrabarti, P., Chaudhuri, B.N., Sethi, T., Lodha, R., Haas, R.E. (2021). 2AI&7D Model of Resistomics to Counter the Accelerating Antibiotic Resistance and the Medical Climate Crisis. In: Srirama, S.N., Lin, J.CW., Bhatnagar, R., Agarwal, S., Reddy, P.K. (eds) Big Data Analytics. BDA 2021. Lecture Notes in Computer Science(), vol 13147. Springer, Cham. https://doi.org/10.1007/978-3-030-93620-4_4
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