Abstract
The Cardiac Syndrome X (CSX) includes patients with the triad of angina pectoris: a positive exercise-strain test and angiographically smooth coronary arteries. The most manifested clinical symptom is chest pain. The aim of the study is to explore the differences in ischemia mechanism in both groups – CSX and patients with Coronary Artery Disease (CAD), based on specific changes in Autonomic Cardiac Control (ACC). A novel approach for multicriteria decision making – InterCriteria Analysis (ICrA) is used to reveal relationships between 13 standard indicators for Heart Rate Variability (HRV) – in resting state (RS) and by sympathetic stimulation (handgrip test; HT) or parasympathetic stimulation (Valsalva manoeuvre; VM). Through these indicators the activity of ACC in two groups (patients with CSX or CAD), each one containing 40 patients, is evaluated. In the considered here three cases all pairs of the 13 indicators, without exception, do not show any dependencies. These results give reason to assume, that in the two groups there is a different response of the sympathetic autonomic system under conditions of stress with matching parasympathetic tone.
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Acknowledgements
Work presented here is partially supported by the Bulgarian National Scientific Fund under Grant KP-06-N22/1 “Theoretical Research and Applications of InterCriteria Analysis”.
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Matveev, M., Roeva, O., Petrov, M., Tsonev, S. (2022). Differences in Ischemia Mechanism in Coronary Artery Disease and Cardiac Syndrome X. In: Sotirov, S.S., Pencheva, T., Kacprzyk, J., Atanassov, K.T., Sotirova, E., Staneva, G. (eds) Contemporary Methods in Bioinformatics and Biomedicine and Their Applications. BioInfoMed 2020. Lecture Notes in Networks and Systems, vol 374. Springer, Cham. https://doi.org/10.1007/978-3-030-96638-6_35
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