Abstract
Intensive muscle contractions are accompanied by metabolic changes that could affect the ionic composition of the cytoplasm of muscle fibre and thus its resistivity. We aim to study the effects of intracellular resistivity on intracellular action potentials (IAPs) and extracellular potentials (EPs). The Hodgkin-Huxley type mathematical model was used to simulate the intracellular processes in a muscle fibre. The spatial potential profile of the IAP was used to calculate the EP. The results showed that changes in the intracellular resistivity had practically no effect on the amplitude and shape of IAP in the temporal domain. The main effect was on the velocity of IAP propagation and thus on the length of IAP profile in the spatial domain. Changes in the length of the IAP profile affected the amplitude of the EPs above the end-plate region and above the middle of the fibre semilength to a similar extent. Effects of changes in the velocity of IAP propagation on the duration of the main negative phase of EPs were similar for detection above the end-plate region and above the middle of the fibre semilength. The results will help in analysis of changes in the M-waves obtained during and after muscle activity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adrian, R.H., Chandler, W.K., Hodgkin, A.L.: Voltage clamp experiments in striated muscle fibres. J. Physiol. 208(3), 607–644 (1970)
Botter, A., Merletti, R.: EMG of electrically stimulated muscles. In: Merletti, R., Farina, D. (eds.) Surface Electromyography. Physiology, Engineering, and Applications. IEEE Press Series in Biomedical Engineering, pp. 311–332. Wiley, New Jersey (2016)
Cupido, C.M., Galea, V., McComas, A.J.: Potentiation and depression of the M wave in human biceps brachii. J Physiol. 491(2), 541–550 (1996)
Dimitrov, G.V., Dimitrova, N.A.: Precise and fast calculation of the motor unit potentials detected by a point and rectangular plate electrode. Med. Eng. Phys. 20(5), 374–381 (1998)
Dimitrova, N.: Influence of the length of the depolarized zone on the extracellular potential field of a single unmyelinated nerve fibre. Electromyogr. Clin. Neurophysiol. 13(5), 547–558 (1973)
Dimitrova, N.A., Dimitrov, G.V.: Amplitude-related characteristics of motor unit and M-wave potentials during fatigue. A simulation study using literature data on intracellular potential changes found in vitro. J. Electromyogr. Kinesiol. 12(5), 339–349 (2002)
Dimitrova, N.A., Dimitrov, G.V.: Electromyography (EMG) modeling. In: Metin, A. (ed.) Wiley Encyclopedia of Biomedical Engineering. Wiley, New Jersey (2006)
Hanson, J., Persson, A.: Changes in the action potential and contraction of isolated frog muscle after repetitive stimulation. Acta Physiol. Scand. 81(3), 340–348 (1971)
Hanson, J.: Effects of repetitive stimulation on membrane potentials and twitch in human and rat intercostal muscle fibres. Acta Physiol. Scand. 92(2), 238–248 (1974)
Hodgkin, A.L., Huxley, A.F.: A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 117(4), 500–544 (1952)
Hoffman, E.K., Lambert, I.H., Pedersen, S.F.: Physiology of cell volume regulation in vertebrates. Physiol. Rev. 89(1), 193–277 (2009)
Kay, A.R., Blaustein, M.P.: Evolution of our understanding of cell volume regulation by the pump-leak mechanism. J. Gen. Physiol. 151(4), 407–416 (2019)
Kleinpenning, P.H., Gootzen, T.H.J.M., Van Oosterom, A., Stegeman, D.F.: The equivalent source description representing the extinction of an action potential at a muscle fiber ending. Math. Biosci. 101(1), 41–61 (1990)
Okada, Y.: Ion channels and transporters involved in cell volume regulation and sensor mechanisms. Cell Biochem. Biophys. 41(2), 233–258 (2004)
Rodriguez-Falces, J.: The formation of extracellular potentials over the innervation zone: are these potentials affected by changes in fibre membrane properties? Med. Biol. Eng. Comput. 54(12), 1845–1858 (2016). https://doi.org/10.1007/s11517-016-1487-8
Rodriguez-Falces, J., Vieira, T., Place, N., Botter, A.: Potentiation of the first and second phases of the M wave after maximal voluntary contractions in the biceps brachii muscle. Med. Biol. Eng. Comput. 57(10), 2231–2244 (2019). https://doi.org/10.1007/s11517-019-02025-7
Sjogaard, G., Adams, R.P., Saltin, B.: Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension. Am J Physiol. 248(2 Pt2), R190–R196 (1985)
Stephanova, D.I., Dimitrov, G.V.: Mathematical modelling of ionic processes in human skeletal muscle fibres. Electromyogr. Clin. Neurophysiol. 22(5), 329–347 (1982)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Dimitrov, V.G., Dimitrov, A.G. (2022). Effect of Changes in the Intracellular Resistivity of Skeletal Muscle Fibre on Intracellular and Extracellular Potentials. In: Sotirov, S.S., Pencheva, T., Kacprzyk, J., Atanassov, K.T., Sotirova, E., Staneva, G. (eds) Contemporary Methods in Bioinformatics and Biomedicine and Their Applications. BioInfoMed 2020. Lecture Notes in Networks and Systems, vol 374. Springer, Cham. https://doi.org/10.1007/978-3-030-96638-6_43
Download citation
DOI: https://doi.org/10.1007/978-3-030-96638-6_43
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-96637-9
Online ISBN: 978-3-030-96638-6
eBook Packages: EngineeringEngineering (R0)