Abstract
Antimicrobial resistance poses a serious health problem. Computational and statistical approaches have been developed for bacterial antimicrobial resistance discovery and classification. Next generation sequencing technologies allows us to analyze complex metagenomes and the presence of resistomes in them. In this work we apply Bayesian hierarchical spatial model to estimate the relative risk of antimicrobial resistance related taxa by using the available spatial information of the samples.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Thomas, C., Nielsen, K.: Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat. Rev. Microbiol. 3, 711–721 (2005)
Bennani, H., Mateus, A., Mays, N., Eastmure, E., Stärk, K.D.C., Häsler, B.: Overview of evidence of antimicrobial use and antimicrobial resistance in the food chain. Antibiotics (Basel) 9(2), 49 (2020)
Okeke, I.N., Edelman, R.: Dissemination of antibiotic-resistant bacteria across geographic 444 borders. Clin. Infect. Dis. 33, 364–369 (2001). https://doi.org/10.1086/321877
Lal Gupta, C., Kumar Tiwari, R., Cytryn, E.: Platforms for elucidating antibiotic resistance in single genomes and complex metagenomes. Environ. Int. 138, 105667 (2020)
Van Camp, P.J., Haslam, D.B., Porollo, A.: Bioinformatics approaches to the understanding of molecular mechanisms in antimicrobial resistance. Int. J. Mol. Sci. 21(4), 1363 (2020)
Hüls, A., Frömke, C., Ickstadt, K., et al.: Antibiotic resistances in livestock: a comparative approach to identify an appropriate regression model for count data. Front Vet Sci. 4, 71 (2017)
MetaSUB International Consortium: The metagenomics and metadesign of the subways and urban biomes (MetaSUB) international consortium inaugural meeting report. Microbiome 4(1), 24 (2016)
Bolger, A.M., Lohse, M., Usadel, B.: Trimmomatic: a flexible trimmer for illumina sequence data. Bioinformatics 30(15), 2114–2120 (2014)
National Database of Antibiotic Resistant Organisms (NDARO). https://www.ncbi.nlm.nih.gov/pathogens/antimicrobial-resistance/
Menzel, P., et al.: Fast and sensitive taxonomic classification for metagenomics with Kaiju. Nat. Commun. 7, 11257 (2016)
Danko, D., et al.: Global genetic cartography of urban metagenomes and anti-microbial resistance. bioRxiv, accepted in Science (2019)
Feargal, J.R.: Application of machine learning techniques for creating urban microbial fingerprints. Biol. Direct 14(1), 13 (2019)
Lee, D.: CARBayes: an R package for Bayesian spatial modeling with conditional autoregressive priors. J. Stat. Softw. 55(13), 1–24 (2013)
Besag, J., York, J., Mollie, A.: Bayesian image restoration with two applications in spatial statistics. Ann. Inst. Stat. Math. 43, 1–59 (1991)
Lawson, A.B.: Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, 3rd edn. Chapman and Hall/CRC (2018)
Geweke, J.: Evaluating the accuracy of sampling-based approaches to calculating posterior moments. In: Bernado, J.M., Berger, J.O., Dawid, A.P., Smith, A.F.M. (eds.) Bayesian Statistics, vol. 4. Clarendon Press, Oxford (1992)
Gittleman, J.L., Kot, M.: Adaptation: statistics and a null model for estimating phylogenetic effects. Syst. Zool. 39, 227–241 (1990)
BatchGeo. https://www.batchgeo.com/
Leroux, B., Lei, X., Breslow, N.: Estimation of disease rates in small areas: a new mixed model for spatial dependence. In: Halloran, M., Berry, D. (eds.) Statistical Models in Epidemiology, the Environment and Clinical Trials, vol. 116, pp. 179–191. Springer, New York (2000). https://doi.org/10.1007/978-1-4612-1284-3_4
Lee, D., Mitchell, R.: Boundary detection in disease mapping studies. Biostatistics 13, 415–426 (2012)
Lee, D., Sarran, C.: Controlling for unmeasured confounding and spatial misalignment in long-term air pollution and health studies. Environmetrics 26, 477–487 (2015)
Acknowledgements
This work was supported by project BG05M2OP001-1.001-0004 (UNITE) for the coverage of conference fee and the National Scientific Program Information and Communication Technologies for a Single Digital Market in Science, Education and Security (ICTinSES) for logistics. In addition, this work was partially supported by the financial funds allocated to the Sofia University St. Kl. Ohridski, grant No. 80-10-116/2020.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Ethics declarations
The opinions expressed in this work are personal and do not represent in any way Bristol Myers-Squibb. No Bristol Myers-Squibb resources were used to generate results or prepare this paper.
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Zhelyazkova, M. et al. (2022). Bayesian Hierarchical Modelling for Antimicrobial Resistance. In: Sotirov, S.S., Pencheva, T., Kacprzyk, J., Atanassov, K.T., Sotirova, E., Staneva, G. (eds) Contemporary Methods in Bioinformatics and Biomedicine and Their Applications. BioInfoMed 2020. Lecture Notes in Networks and Systems, vol 374. Springer, Cham. https://doi.org/10.1007/978-3-030-96638-6_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-96638-6_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-96637-9
Online ISBN: 978-3-030-96638-6
eBook Packages: EngineeringEngineering (R0)