Abstract
A new bioreactor design for the cultivation of anchorage-dependent cell cultures in a monolayer was developed. Computational simulation of hydrodynamic in the developed apparatus and the reference bioreactor Xpansion (Pall) were carried out. The modeling was carried out in the CFX module (Ansys) using the k-e turbulence model. For two constructions results were obtained for the velocity of fluid, the rate of shear forces, and the shear stress on the walls of the anchorage of the cells. The obtained results show better hydrodynamic characteristics of the developed apparatus design.
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Korobiichuk, I., Semeniuk, S., Shybetskyi, V., Kostyk, S., Povodzinsky, V. (2022). Development of a Bioreactor Design for Cultivation of Cell Cultures. In: Szewczyk, R., Zieliński, C., Kaliczyńska, M. (eds) Automation 2022: New Solutions and Technologies for Automation, Robotics and Measurement Techniques. AUTOMATION 2022. Advances in Intelligent Systems and Computing, vol 1427. Springer, Cham. https://doi.org/10.1007/978-3-031-03502-9_32
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