Abstract
To present time, the world science has accumulated a sufficient amount of information on the quantitative changes in the rate of glucose utilization according to positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) in Parkinson’s disease (PD) with dementia. It was found that in the early stages of dementia with PD, there is a dysfunction of the frontal lobes, while PET examination of patients with PD with dementia shows the quantitative changes in the rate of glucose utilization. On this basis, it seems relevant to compare the functional state of the brain structures and the results of neuropsychological studies in patients with PD with varying severity of cognitive impairment. The present research was aimed to investigate the relationship between early cognitive violations according to neuropsychological research and the rate of glucose metabolism in different brain areas during PET scanning in patients with Parkinson’s disease. Neuropsychological testing consisted of clinical interviews, observation, questioning, Mini-Mental State Exam (MMSE) and frontal assessment battery (FAB). According to the research outcomes, it was found that with initial cognitive impairment, determined by FAB, a quantitative change in the rate of glucose utilization is observed, similar to the pattern found in patients with cognitive disorders in PD. Four factors were established: factor 1 – dorsal system of attention (voluntary attention), factor 2 – ventral system of attention (involuntary attention), factor 3 – system of the state of operational rest, factor 4 – visual projective zone. The precentral cortex of the frontal areas and the upper half of the parietal zones of big brain are constitute the 1st factor. The anterior third of the convexital part of the frontal areas and the lower half of the parietal zones are the 2nd factor. The 3rd factor includes the 23, 36, 29 and 30 cytoarchitectonic Brodmann fields (the posterior cingulate gyrus). Primary visual area (17th Brodmann’s field) is the 4th factor.
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References
Aarsland, D., Zaccai, J., Brayne, C.: A systematic review of prevalence studies of dementia in Parkinson’s disease. Mov. Disord. 20, 1255–1263 (2005)
Bridges, R.L., Cho, C.S., Beck, M.R., Gessner, B.D., Tower, S.S.: F-18 FDG PET brain imaging in symptomatic arthroprosthetic cobaltism. Eur. J. Nucl. Med. Mol. Imaging 47(8), 1961–1970 (2019). https://doi.org/10.1007/s00259-019-04648-2
Buchert, R., Buhmann, C., Apostolova, I., Meyer, P.T., Gallinat, J.: Nuclear imaging in the diagnosis of clinically uncertain parkinsonian syndromes. Dtsch. Arztebl. Int. 116, 747–754 (2019)
Campoy, A.-D.T., Liang, C., Ladwa, R.M., et al.: [18F] Nifene PET/CT imaging in mice: improved methods and preliminary studies of α4β2* nicotinic acetylcholinergic receptors in transgenic A53T mouse model of α-synucleinopathy and post-mortem human Parkinson’s disease. Molecules 26, 7360 (2021)
Cohen, O.S., Vakil, E., Tanne, D., et al.: The frontal assessment battery as a tool for evaluation of frontal lobe dysfunction in patients with Parkinson disease. J. Geriatr. Psychiatry Neurol. 2, 71–77 (2012)
Ferri, C.P., Prince, M., Brayne, C., et al.: Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112–2117 (2005)
Folstein, M.F., Folstein, S.E., McHugh, P.R.: Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatric Res. 2, 189–198 (1975)
Fujimi, K., Sasaki, K., Noda, K., et al.: Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study. Brain Pathol. (Zurich, Switzerland). 18, 317–325 (2008)
Gan, J., Liu, S., Wang, X., et al.: Clinical characteristics of Lewy body dementia in Chinese memory clinics. BMC Neurol. 21, 144 (2021)
Hely, M.A., Morris, J.G., Reid, W.G.: Sydney multicenter study of Parkinson’s disease: non-L-dopa-responsive problems dominate at 15 years. Mov. Disord. 3, 190–199 (2005)
Kane, J.P.M., Surendranathan, A., Bentley, A., et al.: Clinical prevalence of Lewy body dementia. Alz. Res. Ther. 10, 19 (2018). https://doi.org/10.1186/s13195-018-0350-6
Khil’ko, V., Shostak, V., Khlunovskiǐ, A., et al.: The topographic mapping of evoked bioelectrical activity and other methods for the functional neural visualization of the brain. Vestn. Ross. Akad. Med. Nauk 3, 36–41 (1993)
Leh, S.E., Petrides, M., Strafella, A.P.: The neural circuitry of executive functions in healthy subjects and Parkinson’s disease. Neuropsychopharmacology 1, 70–85 (2010)
Loane, C., Politis, M.: Positron emission tomography neuroimaging in Parkinson’s disease. Am. J. Transl. Res. 3, 323–341 (2011)
Lytaev, S.A., Susin, D.S.: PET-diagnostics of cognitive impairment in patients with Parkinson’s disease. Pediatrician 7, 63–68 (2016)
Lytaev, S., Aleksandrov, M., Popovich, T., Lytaev, M.: Auditory evoked potentials and PET-scan: early and late mechanisms of selective attention. Adv. Intell. Syst. Comput. 775, 169–178 (2019)
Lytaev, S.: Modern neurophysiological research of the human brain in clinic and psychophysiology. In: Rojas, I., Castillo-Secilla, D., Herrera, L.J., Pomares, H. (eds.) BIOMESIP 2021. LNCS, vol. 12940, pp. 231–241. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-88163-4_21
Lytaev, S.: Modeling and estimation of physiological, psychological and sensory indicators for working capacity. Adv. Intell. Syst. Comput. 1201, 207–213 (2021)
Lytaev, S.: Long-latency event-related potentials (300–1000 ms) of the visual insight. Sensors 22, 1323 (2022)
Murray, P.S., Kumar, S., Demichele-Sweet, M.A., Sweet, R.A.: Psychosis in Alzheimer’s disease. Biol. Psychiatry 75, 542–552 (2014)
Palmqvist, S., Hansson, O., Minthon, L., Londos, E.: Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer’s disease with common cognitive tests. Int. J. Geriatr. Psychiatry 24, 1405–1412 (2009)
Poston, K.L., Eidelberg, D.: FDG PET in the evaluation of Parkinson’s disease. PET Clin. 1, 55–64 (2010)
Silverman, D.H.S., Mosconi, L., Ercoli, L., et al.: PET scans obtained for evaluation of cognitive dysfunction. Semin. Nucl. Med. 38, 251–261 (2008)
Surendranathan, A., Kane, J.P.M., Bentley, A., et al.: Clinical diagnosis of Lewy body dementia. BJPsych Open 6, e61 (2020)
Szeto, J.Y.Y., Walton, C.C., Rizos, A., et al.: Dementia in long-term Parkinson’s disease patients: a multicentre retrospective study. NPJ Parkinson’s Dis. 6, 2 (2020)
Talairach, J., Tournoux, P.: Co-planar stereotactic atlas of the human brain. In: 3-Dimensional Proportional System: An Approach to Cerebral Imaging, pp. 5–15. Thieme, New York (1988)
Taylor, J.P., McKeith, I.G., Burn, D.J., et al.: New evidence on the management of Lewy body dementia. Lancet Neurol. 19, 157–169 (2020)
Thompson, E., Marrett, C., et al.: Performance evaluation of the PC-2048: a new 15-slice encoded-crystal PET scanner for neurological studies. IEEE Trans. Med. Imaging 2, 90–95 (1991)
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Lytaev, S. (2022). PET-Neuroimaging and Neuropsychological Study for Early Cognitive Impairment in Parkinson’s Disease. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L.J., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2022. Lecture Notes in Computer Science(), vol 13346. Springer, Cham. https://doi.org/10.1007/978-3-031-07704-3_12
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