Skip to main content

Integrating Machine Learning and Sensors for the Development of Organ-on-Chip Platforms for Medical Diagnosis

  • Conference paper
  • First Online:
Sensors and Microsystems (AISEM 2021)

Abstract

The development of microfluidics-based devices has opened the way to tremendous advances in many different biomedical contexts, as for example, organ-on-chip (OOC) experiments. However, to exploit the full potential of this technology, the integration with sensors and the analysis of experimental data are also necessary. In this paper, some examples of how we can improve the OOC performances through the development of ad-hoc sensors and the application of machine learning algorithms to process the huge amount of data collected in the OOC experiments are shown.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Zhu, J.: Application of organ-on-chip in drug discovery. J. Biosci. Med. 8(3), 119–134 (2020)

    Google Scholar 

  2. Picollet-D’hahan, N., et al.: Multiorgan-on-a-chip: a systemic approach to model and decipher inter-organ communication. Trends Biotechnol. 39(8), 788–810 (2021)

    Google Scholar 

  3. Clarke, G.A., et al.: Advancement of sensor integrated organ-on-chip devices. Sensors 21(4), 1367 (2021)

    Article  Google Scholar 

  4. Mattei, F., et al.: Oncoimmunology meets organs-on-chip. Front. Mol. Biosci. 8 (2021)

    Google Scholar 

  5. Comes, M.C., et al.: Accelerating the experimental responses on cell behaviors: a long-term prediction of cell trajectories using social generative adversarial network. Sci. Rep. 10(1) (2020)

    Google Scholar 

  6. Mencattini, A., et al.: Discovering the hidden messages within cell trajectories using a deep learning approach for in vitro evaluation of cancer drug treatments. Sci. Rep. 10(1), 1–11 (2020)

    Article  Google Scholar 

  7. Mencattini, A., et al.: High-throughput analysis of cell-cell crosstalk in ad hoc designed microfluidic chips for oncoimmunology applications. In: Methods in Enzymology, vol. 632 (2020)

    Google Scholar 

  8. Comes, M.C., et al.: The influence of spatial and temporal resolutions on the analysis of cell-cell interaction: a systematic study for time-lapse microscopy applications. Sci. Rep. 9(1), 1–11 (2019)

    Article  MathSciNet  Google Scholar 

  9. Biselli, E., et al.: Organs on-chip approach: a tool to evaluate cancer-immune cells interactions. Sci. Rep. 7(1), 1–12 (2017)

    Article  Google Scholar 

  10. Nguyen, M., et al.: Dissecting effects of anti-cancer drugs and cancer-associated fibroblasts by on-chip reconstitution of immunocompetent tumor microenvironments. Cell Rep. 25(13), 3884–3893 (2018)

    Article  Google Scholar 

  11. Veith, I., et al.: Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death. PLoS Comput. Biol. 17(3), e1008870 (2021)

    Article  Google Scholar 

  12. Rizzuto, V., et al.: Combining microfluidic spleen-like filtering unit with machine learning algorithms to characterize rare hereditary hemolytic anemia (2021, submitted)

    Google Scholar 

  13. D'orazio, M., et al.: Deciphering cancer cell behavior from motility and shape features: peer prediction and dynamic selection to support cancer diagnosis and therapy. Front. Oncol. (2020)

    Google Scholar 

  14. Comes, M.C., et al.: A camera sensors-based system to study drug effects on in vitro motility: the case of PC-3 prostate cancer cells. Sensors 20(5), 1531 (2020)

    Article  Google Scholar 

  15. Di Giuseppe, D., et al.: Learning cancer-related drug efficacy exploiting consensus in coordinated motility within cell clusters. IEEE Trans. Biomed. Eng. 66(10), 2882–2888 (2019)

    Article  Google Scholar 

  16. Badiola-Mateos, M., et al.: A novel multi-frequency trans-endothelial electrical resistance (MTEER) sensor array to monitor blood-brain barrier integrity. Sens. Actuators B: Chem. 334, 129599 (2021)

    Article  Google Scholar 

  17. Cascarano, P., et al.: Recursive deep prior video: a super resolution algorithm for time-lapse microscopy of organ-on-chip experiments. Med. Image Anal. 72, 102124 (2021)

    Article  Google Scholar 

  18. Mencattini, A., et al.: From petri dishes to organ on-chip platform: the increasing importance of machine learning and image analysis. Front. Pharmacol. 10, 100 (2019)

    Article  Google Scholar 

  19. Ongaro, E., et al.: Polylactic is a sustainable, low absorption, low autofluorescence alternative to other plastics for microfluidic and organ-on-chip applications. Anal. Chem. 92(9), 6693–6701 (2020)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eugenio Martinelli .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Mencattini, A. et al. (2023). Integrating Machine Learning and Sensors for the Development of Organ-on-Chip Platforms for Medical Diagnosis. In: Di Francia, G., Di Natale, C. (eds) Sensors and Microsystems. AISEM 2021. Lecture Notes in Electrical Engineering, vol 918. Springer, Cham. https://doi.org/10.1007/978-3-031-08136-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-08136-1_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-08135-4

  • Online ISBN: 978-3-031-08136-1

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics