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A Novel Survival Analysis Approach to Predict the Need for Intubation in Intensive Care Units

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Artificial Intelligence in Medicine (AIME 2022)

Abstract

Intubation for mechanical ventilation (MV) is a common procedure performed in Intensive Care Units (ICUs). Early prediction of the need for intubation may have a positive impact by providing timely alerts to clinicians and consequently avoiding high risk late intubations. In this work, we propose a new machine learning method to predict intubation for MV, based on the concept of cure survival models. We tested our approach and compared it to other predictive models on a dataset collected from a secondary care hospital (AZ Groeninge, Kortrijk, Belgium). The results corroborate that our approach can improve the prediction of the need for intubation for MV in critically ill patients by using routinely collected data within the first hours of admission in the ICU. Early warning of need for intubation may be used to help clinicians predicting the risk of intubation and ranking patients according to their expected time to intubation.

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References

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Acknowledgements

This research was funded by the Research Fund Flanders (project G0A2120N). The authors also acknowledge the Flemish Government (AI Research Program).

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Correspondence to Michela Venturini or Celine Vens .

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Appendix

Appendix

(See Fig. 2 and Tables 2 and 3).

Fig. 2.
figure 2

Kaplan-Meier survival estimate.

Table 2. Cohort characteristics. RF patients with respiratory failure, COPD patients with chronic obstructive pulmonary disease, HR heart rate, RR respiratory rate, SBP systolic blood pressure, DBP diastolic blood pressure. Values are expressed in median and interquartile range, unless differently specified.
Table 3. FIDDLE custom parameters. T size of the time window, dt granularity of the window, Theta 1 threshold for the pre-filter step, Theta 2 threshold for the post filter step, Theta freq average number of measurements per time window at which a variable is considered frequent “frequent”.

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Venturini, M., Van Keilegom, I., De Corte, W., Vens, C. (2022). A Novel Survival Analysis Approach to Predict the Need for Intubation in Intensive Care Units. In: Michalowski, M., Abidi, S.S.R., Abidi, S. (eds) Artificial Intelligence in Medicine. AIME 2022. Lecture Notes in Computer Science(), vol 13263. Springer, Cham. https://doi.org/10.1007/978-3-031-09342-5_35

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  • DOI: https://doi.org/10.1007/978-3-031-09342-5_35

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-09341-8

  • Online ISBN: 978-3-031-09342-5

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