Abstract
Resting state brain networks have reached a strong popularity in recent scientific endeavors due to their feasibility to characterize the metabolic mechanisms at the basis of neural control when the brain is not engaged in any task. The evaluation of these states, consisting in complex physiological processes employing a large amount of energy, is carried out from diagnostic images acquired through resting-state functional magnetic resonance (RS-fMRI) on different populations of subjects. In the present study, RS-fMRI signals from the WU-Minn HCP 1200 Subjects Data Release of the Human Connectome Project were studied with the aim of investigating the high order organizational structure of the brain function in resting conditions. Image data were post-processed through Independent Component Analysis to extract the so-called Intrinsic Component Networks, and a recently proposed framework for assessing high-order interactions in network data through the so-called O-Information measure was exploited. The framework allows an information-theoretic evaluation of pairwise and higher-order interactions, and was here extended to the analysis of vector variables, to allow investigating interactions among multiple Independent Component Networks (ICNs) each composed by several brain regions. Moreover, surrogate data analysis was used to validate statistically the detected pairwise and high-order networks. Our results indicate that RSNs are dominated by redundant interactions among ICN subnetworks, with levels of redundancy that increase monotonically with the order of the interactions analyzed. The ICNs mostly involved in the interactions of any order were the Default Mode and the Cognitive Control networks, suggesting a key role of these areas in mediating brain interactions during the resting state. Future works should assess the alterations of these patterns of functional brain connectivity during task-induced activity and in pathological states.
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References
Glover, G.H.: Overview of functional magnetic resonance imaging. Neurosurg. Clin. N. Am. 22, 133–139 (2011). https://doi.org/10.1016/j.nec.2010.11.001
Chow, M.S., Wu, S.L., Webb, S.E., Gluskin, K., Yew, D.: Functional magnetic resonance imaging and the brain: a brief review. World J. Radiol. 9, 5 (2017). https://doi.org/10.4329/wjr.v9.i1.5
Duyn, J.: Spontaneous fMRI activity during resting wakefulness and sleep. Prog. Brain Res. 193, 295–305 (2011). https://doi.org/10.1016/B978-0-444-53839-0.00019-3
Fox, M.D., Raichle, M.E.: Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat. Rev. Neurosci. 8, 700–711 (2007). https://doi.org/10.1038/nrn2201
Agnello, L., Comelli, A., Ardizzone, E., Vitabile, S.: Unsupervised tissue classification of brain MR images for voxel-based morphometry analysis. Int. J. Imaging Syst. Technol. 26, 136–150 (2016). https://doi.org/10.1002/ima.22168
Ran, Q., Jamoulle, T., Schaeverbeke, J., Meersmans, K., Vandenberghe, R., Dupont, P.: Reproducibility of graph measures at the subject level using resting-state fMRI. Brain Behav. 10, 2336–2351 (2020). https://doi.org/10.1002/brb3.1705
Almgren, H., Van de Steen, F., Razi, A., Friston, K., Marinazzo, D.: The effect of global signal regression on DCM estimates of noise and effective connectivity from resting state fMRI. Neuroimage 208, 116435 (2020). https://doi.org/10.1016/j.neuroimage.2019.116435
Almgren, H., Van de Steen, F., Kühn, S., Razi, A., Friston, K., Marinazzo, D.: Variability and reliability of effective connectivity within the core default mode network: a multi-site longitudinal spectral DCM study. Neuroimage 183, 757–768 (2018). https://doi.org/10.1016/j.neuroimage.2018.08.053
Behzadi, Y., Restom, K., Liau, J., Liu, T.T.: A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage 37, 90–101 (2007). https://doi.org/10.1016/j.neuroimage.2007.04.042
Sparacia, G., et al.: Resting-state functional connectome in patients with brain tumors before and after surgical resection. World Neurosurg. 141, e182–e194 (2020). https://doi.org/10.1016/j.wneu.2020.05.054
De Vico Fallani, F., Latora, V., Chavez, M.: A topological criterion for filtering information in complex brain networks. PLoS Comput. Biol. 13, 1–18 (2017). https://doi.org/10.1371/journal.pcbi.1005305
Garrison, K.A., Scheinost, D., Finn, E.S., Shen, X., Todd, R., Program, N.: The (in)stability of functional brain network measures across thresholds. NeuroImage 118, 651–661 (2016). https://doi.org/10.1016/j.neuroimage.2015.05.046
Calhoun, V.D., Adali, T., Pearlson, G.D., Pekar, J.J.: A method for making group inferences from functional MRI data using independent component analysis V.D. J. Neurotrauma 32, 655–659 (2015). https://doi.org/10.1089/neu.2014.3723
Faes, L., et al.: A Framework for the time- and frequency-domain assessment of high-order interactions in brain and physiological networks. XX, pp. 1–11 (2022)
Stramaglia, S., Scagliarini, T., Daniels, B.C., Marinazzo, D.: Quantifying dynamical high-order interdependencies from the O-information: an application to neural spiking dynamics. Front. Physiol. 11, 1–11 (2021). https://doi.org/10.3389/fphys.2020.595736
Rosas, F.E., Mediano, P.A.M., Gastpar, M., Jensen, H.J.: Quantifying high-order interdependencies via multivariate extensions of the mutual information. Phys. Rev. E. 100, 32305 (2019). https://doi.org/10.1103/PhysRevE.100.032305
Elam, J.S., Van Essen, D.: WU-Minn HCP 1200 subjects data release reference manual. Encycl. Comput. Neurosci. 2017, 35 (2013). https://doi.org/10.1007/978-1-4614-7320-6_592-1
Glasser, M.F., et al.: The minimal preprocessing pipelines for the human connectome project and for the WU-Minn HCP consortium. Neuroimage 80, 105–12404 (2013). https://doi.org/10.1016/j.neuroimage.2013.04.127.The
Fu, Z., Du, Y., Calhoun, V.D.: The Dynamic Functional Network Connectivity Analysis Framework. Engineering 5, 190–193 (2019). https://doi.org/10.1016/j.eng.2018.10.001
Sako, Ü., Pearlson, G.D., Kiehl, K.A., Wang, Y.M., Andrew, M., Calhoun, V.D.: A method for evaluating dynamic functional network connectivity and task-modulation. App. Schizophrenia 23, 351–366 (2010). https://doi.org/10.1007/s10334-010-0197-8.A
Bell, A.J., Sejnowski, T.J.: An information-maximization approach to blind separation and blind deconvolution. Neural Comput. 7, 1129–1159 (1995)
Faes, L., Marinazzo, D., Stramaglia, S.: Multiscale information decomposition: exact computation for multivariate Gaussian processes. Entropy 19, 1–18 (2017). https://doi.org/10.3390/e19080408
Barrett, A.B., Barnett, L., Seth, A.K.: Multivariate granger causality and generalized variance. Phys. Rev. E - Stat. Nonlinear, Soft Matter Phys. 81, (2010). https://doi.org/10.1103/PhysRevE.81.041907
over, T.M., Thomas, J.A.: Elements of Information Theory. John Wiley & Sons, New York (2012)
Pernice, R., et al.: Multivariate correlation measures reveal structure and strength of brain – body physiological networks at rest and during mental stress. Front Neurosci. 14 (2021). https://doi.org/10.3389/fnins.2020.602584
Paluš, M.: Detecting phase synchronization in noisy systems. Phys. Lett. Sect. A Gen. Solid State Phys. 235, 341–351 (1997). https://doi.org/10.1016/S0375-9601(97)00635-X
Raichle, M.E.: The brain’s default mode network. Annu. Rev. Neurosci. 38, 433–447 (2015). https://doi.org/10.1146/annurev-neuro-071013-014030
Greicius, M.D., Krasnow, B., Reiss, A.L., Menon, V.: Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc. Natl. Acad. Sci. U. S. A. 100, 253–258 (2003). https://doi.org/10.1073/pnas.0135058100
Wu, G.R., Marinazzo, D.: Sensitivity of the resting-state haemodynamic response function estimation to autonomic nervous system fluctuations. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 374, 20150190 (2016)
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Valenti, S. et al. (2022). Assessing High-Order Interdependencies Through Static O-Information Measures Computed on Resting State fMRI Intrinsic Component Networks. In: Mazzeo, P.L., Frontoni, E., Sclaroff, S., Distante, C. (eds) Image Analysis and Processing. ICIAP 2022 Workshops. ICIAP 2022. Lecture Notes in Computer Science, vol 13373. Springer, Cham. https://doi.org/10.1007/978-3-031-13321-3_34
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