Abstract
Lung nodules can be an alarming precursor to potential lung cancer. Missed nodule detections during chest radiograph analysis remains a common challenge among thoracic radiologists. In this work, we present a multi-task lung nodule detection algorithm for chest radiograph analysis. Unlike past approaches, our algorithm predicts a global-level label indicating nodule presence along with local-level labels predicting nodule locations using a Dual Head Network (DHN). We demonstrate the favorable nodule detection performance that our multi-task formulation yields in comparison to conventional methods. In addition, we introduce a novel Dual Head Augmentation (DHA) strategy tailored for DHN, and we demonstrate its significance in further enhancing global and local nodule predictions.
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Notes
- 1.
The complete list of transformations are detailed in the supplementary materials.
- 2.
FROC and AFROC are computed with an Intersection over Union (IOU) threshold of 0.4, and the FROC-AUC is computed with a False Positive Per-Image up to 1.
References
Ausawalaithong, W., Thirach, A., Marukatat, S., Wilaiprasitporn, T.: Automatic lung cancer prediction from chest x-ray images using the deep learning approach. In: BMEiCON 2018–11th Biomedical Engineering International Conference, vol. 1 (2019). https://doi.org/10.1109/BMEICON.2018.8609997
Busby, L.P., Courtier, J.L., Glastonbury, C.M.: Bias in radiology: the how and why of misses and misinterpretations. Radiographics 38, 236–247 (2018), https://pubs.rsna.org/doi/abs/10.1148/rg.2018170107
Sainz de Cea, M.V., Diedrich, K., Bakalo, R., Ness, L., Richmond, D.: Multi-task learning for detection and classification of cancer in screening mammography. In: Martel, A.L., et al. (eds.) MICCAI 2020. LNCS, vol. 12266, pp. 241–250. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-59725-2_24
Cha, M.J., Chung, M.J., Lee, J.H., Lee, K.S.: Performance of deep learning model in detecting operable lung cancer with chest radiographs. J. Thorac. Imaging 34, 86–91 (2019). https://doi.org/10.1097/RTI.0000000000000388
del Ciello, A., Franchi, P., Contegiacomo, A., Cicchetti, G., Bonomo, L., Larici, A.R.: Missed lung cancer: when, where, and why? Diagn. Intervent. Radiol. 23, 118 (2017). https://doi.org/10.5152/DIR.2016.16187
Dai, J., et al.: Deformable convolutional networks. In: 2017 IEEE International Conference on Computer Vision (ICCV), pp. 764–773 (2017). https://doi.org/10.1109/ICCV.2017.89
He, K., Gkioxari, G., Dollár, P., Girshick, R.B.: Mask R-CNN. In: 2017 IEEE International Conference on Computer Vision (ICCV), pp. 2980–2988 (2017)
He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 770–778 (2016)
Huang, G., Liu, Z., Maaten, L.V.D., Weinberger, K.Q.: Densely connected convolutional networks. In: Proceedings - 30th IEEE Conference on Computer Vision and Pattern Recognition, CVPR 2017 2017-January, pp. 2261–2269, November 2017. https://doi.org/10.1109/CVPR.2017.243
Hwang, E.J., Park, C.M.: Clinical implementation of deep learning in thoracic radiology: potential applications and challenges. Korean J. Radiol. 21, 511–525 (2020). https://doi.org/10.3348/KJR.2019.0821
Kim, Y.G., et al.: Short-term reproducibility of pulmonary nodule and mass detection in chest radiographs: comparison among radiologists and four different computer-aided detections with convolutional neural net. Sci. Rep. 2019 9:1 9, 1–9 (2019). https://doi.org/10.1038/s41598-019-55373-7
Larici, A.R., et al.: Lung nodules: size still matters. Eur. Respir. Rev. official J. Eur. Respir. Soc. 26 (2017). https://doi.org/10.1183/16000617.0025-2017
Li, X., Shen, L., Luo, S.: A solitary feature-based lung nodule detection approach for chest x-ray radiographs. IEEE J. Biomed. Health Inf. 22, 516–524 (2018). https://doi.org/10.1109/JBHI.2017.2661805
Li, Z., et al.: Thoracic disease identification and localization with limited supervision. In: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 8290–8299 (2018). https://doi.org/10.1109/CVPR.2018.00865
Lin, T.Y., Dollár, P., Girshick, R., He, K., Hariharan, B., Belongie, S.: Feature pyramid networks for object detection. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 936–944 (2017). https://doi.org/10.1109/CVPR.2017.106
Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollár, P.: Focal loss for dense object detection. In: 2017 IEEE International Conference on Computer Vision (ICCV), pp. 2999–3007 (2017). https://doi.org/10.1109/ICCV.2017.324
Luo, W., Li, Y., Urtasun, R., Zemel, R.: Understanding the effective receptive field in deep convolutional neural networks. In: Proceedings of the 30th International Conference on Neural Information Processing Systems, NIPS 2016, pp. 4905–4913. Curran Associates Inc. (2016)
Mendoza, J., Pedrini, H.: Detection and classification of lung nodules in chest x-ray images using deep convolutional neural networks. Comput. Intell. 36, 370–401 (2020). https://doi.org/10.1111/COIN.12241
Nam, J.G., et al.: Development and validation of deep learning-based automatic detection algorithm for malignant pulmonary nodules on chest radiographs. Radiology 290, 218–228 (2019). https://pubs.rsna.org/doi/abs/10.1148/radiol.2018180237
Pesce, E., Withey, S.J., Ypsilantis, P.P., Bakewell, R., Goh, V., Montana, G.: Learning to detect chest radiographs containing pulmonary lesions using visual attention networks. Med. Image Anal. 53, 26–38 (2019). https://doi.org/10.1016/J.MEDIA.2018.12.007
Rajpurkar, P., et al.: Chexnet: radiologist-level pneumonia detection on chest x-rays with deep learning. ArXiv abs/1711.05225 (2017)
Ren, S., He, K., Girshick, R., Sun, J.: Faster R-CNN: towards real-time object detection with region proposal networks. IEEE Trans. Pattern Anal. Mach. Intell. 39(6), 1137–1149 (2017). https://doi.org/10.1109/TPAMI.2016.2577031
Rezatofighi, H., Tsoi, N., Gwak, J., Sadeghian, A., Reid, I., Savarese, S.: Generalized intersection over union: a metric and a loss for bounding box regression. In: 2019 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), pp. 658–666 (2019). https://doi.org/10.1109/CVPR.2019.00075
Schultheiss, M., et al.: A robust convolutional neural network for lung nodule detection in the presence of foreign bodies. Sci. Rep. 2020 10:1 10, 1–9 (2020). https://doi.org/10.1038/s41598-020-69789-z
Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. In: International Conference on Learning Representations (2015)
Tack, D., Howarth, N.: Missed lung lesions: side-by-side comparison of chest radiography with MDCT. In: Hodler, J., Kubik-Huch, R.A., von Schulthess, G.K. (eds.) Diseases of the Chest, Breast, Heart and Vessels 2019-2022. ISS, pp. 17–26. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11149-6_2
Tian, Z., Shen, C., Chen, H., He, T.: Fcos: fully convolutional one-stage object detection. In: 2019 IEEE/CVF International Conference on Computer Vision (ICCV), pp. 9626–9635 (2019). https://doi.org/10.1109/ICCV.2019.00972
Wang, X., Peng, Y., Lu, L., Lu, Z., Bagheri, M., Summers, R.M.: Chestx-ray8: hospital-scale chest x-ray database and benchmarks on weakly-supervised classification and localization of common thorax diseases. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017-January, pp. 3462–3471, July 2017. https://doi.org/10.1109/CVPR.2017.369
Acknowledgements
We would like to thank Che-Han Chang and the anonymous reviewers for their valuable suggestions. We also thank the members: Chun-Nan Chou, Fu-Chieh Chang, Yu-Quan Zhang, and Hao-Jen Wang for their support in collecting annotated data, and Yi-Hsiang Chin for his efforts in conducting experiments.
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Tsai, CH., Peng, YS. (2022). Multi-task Lung Nodule Detection in Chest Radiographs with a Dual Head Network. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2022. MICCAI 2022. Lecture Notes in Computer Science, vol 13431. Springer, Cham. https://doi.org/10.1007/978-3-031-16431-6_67
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