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Analysis of Potential Biases on Mammography Datasets for Deep Learning Model Development

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Applications of Medical Artificial Intelligence (AMAI 2022)

Abstract

The development of democratized, generalizable deep learning applications for health care systems is challenging as potential biases could easily emerge. This paper provides an overview of the potential biases that appear in image analysis datasets that affect the development and performance of artificial intelligence algorithms. Especially, an exhaustive analysis of mammography data has been carried out at the patient, image and source of origin levels. Furthermore, we summarize some techniques to alleviate these biases for the development of fair deep learning models. We present a learning task to classify negative and positive screening mammographies and analyze the influence of biases in the performance of the algorithm.

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References

  1. Hammer, G.P., du Prel, J.B., Blettner, M.: Avoiding bias in observational studies: part 8 in a series of articles on evaluation of scientific publications. Dtsch Arztebl Int. 106, 664 (2009)

    Google Scholar 

  2. Yu, A.C., Eng, J.: One algorithm may not fit all: how selection bias affects machine learning performance. Radiographics 40, 1932–1937 (2020)

    Article  Google Scholar 

  3. Varoquaux, G., Cheplygina, V.: How I failed machine learning in medical imaging - shortcomings and recommendations. Electr. Eng. Syst. Sci. (2021)

    Google Scholar 

  4. Tong, S., Kagal, L.: Investigating bias in image classification using model explanations. Comput. Sci. Comput. Vis. Pattern Recogn. (2020)

    Google Scholar 

  5. Oakden-Rayner, L., Dunnmon, J., Carneiro, G., Re, C.: Hidden stratification causes clinically meaningful failures in machine learning for medical imaging. Comput. Sci. Mach. Learn. (2019)

    Google Scholar 

  6. K. Winkler, et al.: Association between surgical skin markings in dermoscopic images and diagnostic performance of a deep learning convolutional neural network for melanoma recognition. JAMA Dermatol (2019)

    Google Scholar 

  7. Pot, M., Kieusseyan, N., Prainsack, B.: Not all biases are bad: equitable and inequitable biases in machine learning and radiology. Insights Imaging 12, 1–10 (2021)

    Google Scholar 

  8. Larrazabal, A.J., Nieto, N., Peterson, V., Milone, D.H., Ferrante, E. Gender imbalance in medical imaging datasets produces biased classifiers for computer-aided diagnosis. In: Proc. Natl. Acad. Sci. USA , 117, 12592–12594 (2020)

    Google Scholar 

  9. Park, S.H., Han, K.: Methodologic guide for evaluating clinical performance and effect of artificial intelligence technology for medical diagnosis and prediction. Radiology 286, 800–809 (2003)

    Article  Google Scholar 

  10. Zhao, Q., Adeli, E., Pohl, K.M.: Training confounder-free deep learning models for medical applications. Nat. Commun. 11, 1–9 (2020)

    Article  Google Scholar 

  11. Li, X., Cui, Z., Wu, Y., Gu, L., Harada, T.: Stimating and improving fairness with adversarial learning. Comput. Sci. Comput. Vis. Pattern Recogn. (2021)

    Google Scholar 

  12. Seyyed-Kalantari, L., Zhang, H., McDermott, M., Chen, I.Y., Ghassemi, M.: Underdiagnosis bias of artificial intelligence algorithms applied to chest radiographs in under-served patient populations. Nat. Med. 27, 2176–2182 (2021)

    Article  Google Scholar 

  13. Catala, O.D.T., et al.: Bias analysis on public x-ray image datasets of pneumonia and Covid-19 patients. IEEE Access. 9, 42370–42383 (2021)

    Article  Google Scholar 

  14. E. H. P. Pooch, P. L. Ballester, R. C. Barros: Can we trust deep learning based diagnosis? the impact of domain shift in chest radiograph classification. Electr. Eng. Syst. Sci. Image Video Process. (2020)

    Google Scholar 

  15. Zech, J.R., Badgeley, M.A., Liu, M., Costa, A.B., Titano, J.J., Oermann, E.K.: Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: a cross-sectional study. PLoS Med. 15, e1002683 (2018)

    Article  Google Scholar 

  16. Yala, A., et al.: Toward robust mammography-based models for breast cancer risk. Sci Transl. Med. 13, eaba4373 (2021)

    Article  Google Scholar 

  17. Mayer McKinney, S., et al.: International evaluation of an AI system for breast cancer screening. Nature 577, 89–94 (2020)

    Article  Google Scholar 

  18. Wu, N., et al.: Deep neural networks improve radiologists’ performance in breast cancer screening. IEEE Trans. Med. Imaging 39, 1184–1194 (2020)

    Article  Google Scholar 

  19. Ganin, Y., et al.: Domain-adversarial training of neural networks. Stat. Mach. Learn. 17, 2096–2130 (2016)

    MathSciNet  Google Scholar 

  20. Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D.: Visual explanations from deep networks via gradient-based localization. In: IEEE International Conference on Computer Vision (ICCV). (2017)

    Google Scholar 

Download references

Acknowledgments

This work has been partially funded by FEDER “Una manera de hacer Europa”. This research has been done within the project CADIA - Sistema de Detecciónn de Diversas Patologíss Basado en el Analisis de Imagen con Inteligencia Artificial (DG-SER1-19-003) under the Codigo100 Public Procurement and Innovation Programme by the Galician Health Service - Servizo Galego de Saude (SERGAS) cofunded by the European Regional Development Fund (ERDF).

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Correspondence to Blanca Zufiria .

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Zufiria, B. et al. (2022). Analysis of Potential Biases on Mammography Datasets for Deep Learning Model Development. In: Wu, S., Shabestari, B., Xing, L. (eds) Applications of Medical Artificial Intelligence. AMAI 2022. Lecture Notes in Computer Science, vol 13540. Springer, Cham. https://doi.org/10.1007/978-3-031-17721-7_7

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  • DOI: https://doi.org/10.1007/978-3-031-17721-7_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-17720-0

  • Online ISBN: 978-3-031-17721-7

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