Abstract
We describe a simulation infrastructure for a comprehensive testing of safety, security and performance in a specific medical device (Relaxometry Controller) being developed by RGB Medical. The apparatus is designed to monitor and regulate patient’s blood pressure and muscle relaxation during surgery and anesthesia. The controller is at the laboratory testing level under ongoing development and before practical deployment it needs full accreditation by national healthcare agencies. By having a simulation infrastructure, we investigated the controller’s übehaviour in various pre-defined clinical test scenarios.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cooper, R.A., Maddineni, V.R., Mirakhur, R.K., Wierda, J.M., Brady, M., Fitzpatrick, K.T.: Time course of neuromuscular effects and pharmacokinetics of rocuronium bromide (Org 9426) during isoflurane anaesthesia in patients with and without renal failure. Brit. J. Anaesth. 71, 222–226 (1993)
Vermeyen, K., Hoffmann, V., Saldien, V.: Target controlled infusion of rocuronium: analysis of effect data to select a pharmacokinetic model. Brit. J. Anaesth. 90, 183–188 (2003)
Hakim, D., Drolet, P., Donati, F., Fortier, L.P.: Performing post-tetanic count during rocuronium blockade has limited impact on subsequent twitch height or train-of-four responses. Can. J. Anaesth. 63, 828–833 (2016)
Sunnen, M., Schläpfer, M., Biro, P.: Automated quantitative relaxometry for deep neuromuscular blockade in robot-assisted prostatectomy. Rom. J. Anaesth. Intensive Care 27, 29–34 (2020)
Schultz, P., Ibsen, M., Østergaard, D., Skovgaard, L.T.: Onset and duration of action of rocuronium-from tracheal intubation, through intense block to complete recovery. Acta Anaesthesiol. Scand. 45, 612–617 (2001)
REDIS. https://redis.io
Acknowledgements
This project has received funding from the ECSEL Joint Undertaking (JU) under grant agreement No 876852. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and Austria, Czech Republic, Germany, Ireland, Italy, Portugal, Spain, Sweden, Turkey.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Hrubý, M., Gonzalez, A., Ruiz Nolasco, R., Biro, P. (2022). Simulation Setup for a Closed-Loop Regulation of Neuro-Muscular Blockade. In: Moreno-Díaz, R., Pichler, F., Quesada-Arencibia, A. (eds) Computer Aided Systems Theory – EUROCAST 2022. EUROCAST 2022. Lecture Notes in Computer Science, vol 13789. Springer, Cham. https://doi.org/10.1007/978-3-031-25312-6_24
Download citation
DOI: https://doi.org/10.1007/978-3-031-25312-6_24
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-25311-9
Online ISBN: 978-3-031-25312-6
eBook Packages: Computer ScienceComputer Science (R0)