Skip to main content

Ince-PD Model for Parkinson’s Disease Prediction Using MDS-UPDRS I & II and PDQ-8 Score

  • Conference paper
  • First Online:
Artificial Intelligence Applications and Innovations (AIAI 2023)

Abstract

Parkinson’s disease (PD) is one of the most prevalent and complex neurodegenerative disorders. Timely and accurate diagnosis is essential for the effectiveness of the initial treatment and improvement of the patients’ quality of life. Since PD is an incurable disease, the early intervention is important to delay the progression of symptoms and severity of the disease. This paper aims to present Ince-PD, a new, highly accurate model for PD prediction based on Inception architectures for time-series classification, using wearable data derived from IoT sensor-based recordings and surveys from the mPower dataset. The feature selection process was based on the clinical knowledge shared by the medical experts through the course of the EU funded project ALAMEDA. Τhe algorithm predicted total MDS-UPDRS I & II scores with a mean absolute error of 1.97 for time window and 2.27 for patient, as well as PDQ-8 scores with a mean absolute error of 2.17 for time window and 2.96 for patient. Our model demonstrates a more effective and accurate method to predict Parkinson Disease, when compared to some of the most significant deep learning algorithms in the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    https://alamedaproject.eu/.

References

  1. Nussbaum, R.L., Ellis, C.E.: Alzheimer’s disease and Parkinson’s disease. New England J. Med. 348(14), 1356–1364 (2003)

    Google Scholar 

  2. Tysnes, O.-B., Storstein, A.: Epidemiology of Parkinson’s disease. J. Neural Transm. (Vienna, Austria: 1996) 124(8), 901–905 (2017)

    Google Scholar 

  3. Pringsheim, T., Jette, N., Frolkis, A., Steeves, T.D.L.: The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov. Disord. 29, 1583–1590 (2014)

    Article  Google Scholar 

  4. Goetz, C.G., et al.: Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. Official J. Mov. Disord. Soc. 23(15), 2129–2170 (2008). https://doi.org/10.1002/mds.22340

  5. Franchignoni, F., et al.: Rasch analysis of the short form 8-item Parkinson’s disease questionnaire (PDQ-8). Qual. Life Res. Int. J. Qual. Life Aspects Treat. Care Rehabil. 17(4), 541–548 (2008)

    Google Scholar 

  6. Katsarou, Z., et al.: Assessing quality of life in Parkinson’s disease: can a short-form questionnaire be useful? Mov. Disord. Official J. Mov. Disord. Soc. 19(3), 308–312 (2004)

    Google Scholar 

  7. Giannakopoulou, K.-M., et al.: Internet of things technologies and machine learning methods for Parkinson’s disease diagnosis, monitoring and management: a systematic review. Sensors (Basel, Switzerland) 22(5), 1799 (2022)

    Google Scholar 

  8. Miele, G., et al.: Telemedicine in Parkinson’s disease: how to ensure patient needs and continuity of care at the time of COVID-19 pandemic. Telemedicine J. E-Health Official J. Am. Telemed. Assoc. 26(12), 1533–1536 (2020)

    Google Scholar 

  9. Podlewska, A.M., van Wamelen, D.J.: Parkinson’s disease and Covid-19: the effect and use of telemedicine. Int. Rev. Neurobiol. 165, 263–281 (2022)

    Google Scholar 

  10. Ossig, C., et al.: Wearable sensor-based objective assessment of motor symptoms in Parkinson’s disease. J. Neural Transm. 123(1), 57–64 (2015). https://doi.org/10.1007/s00702-015-1439-8

    Article  Google Scholar 

  11. Tong, K., Granat, M.H.: A practical gait analysis system using gyroscopes. Med. Eng. Phys. 21(2), 87–94 (1999)

    Google Scholar 

  12. Suzuki, M., et al.: Quantitative analysis of motor status in Parkinson’s disease using wearable devices: from methodological considerations to problems in clinical applications. Parkinson’s Dis. 2017, 6139716 (2017)

    Google Scholar 

  13. Bates, D.W., et al.: Big data in health care: using analytics to identify and manage high-risk and high-cost patients. Health Aff. (Proj. Hope) 33(7), 1123–1131 (2014)

    Google Scholar 

  14. Fawaz, H.I., et al.: InceptionTime: finding AlexNet for time series classification. Data Min. Knowl. Discov. 34, 1936–1962 (2019)

    Google Scholar 

  15. Senturk, Z.K.: Early diagnosis of Parkinson’s disease using machine learning algorithms. Med. Hypotheses 138, 109603 (2020)

    Google Scholar 

  16. Li, A., Li, C.: Detecting Parkinson’s disease through gait measures using machine learning. Diagnostics 12(10), 2404 (2022)

    Article  Google Scholar 

  17. Moradi, S., Tapak, L., Afshar, S.: Identification of novel noninvasive diagnostics biomarkers in the Parkinson’s diseases and improving the disease classification using support vector machine. BioMed. Res. Int. 2022, 8 (2022). Article ID 5009892

    Google Scholar 

  18. Templeton, J.M., Poellabauer, C., Schneider, S.: Classification of Parkinson’s disease and its stages using machine learning. Sci. Rep. 12, 14036 (2022)

    Article  Google Scholar 

  19. Alzubaidi, M.S., et al.: The role of neural network for the detection of Parkinson’s disease: a scoping review. Healthcare (Basel, Switzerland) 9(6) 740 (2021)

    Google Scholar 

  20. Nilashi, M.: Predicting Parkinson’s disease progression: evaluation of ensemble methods in machine learning. J. Healthcare Eng. 2022, 17 (2022). Article ID 2793361

    Google Scholar 

  21. Hssayeni, M.D., Jimenez-Shahed, J., Burack, M.A., et al.: Ensemble deep model for continuous estimation of Unified Parkinson’s disease rating scale III. BioMed. Eng. OnLine 20, 32 (2021)

    Article  Google Scholar 

  22. Zia Ur Rehman, R., et al.: Predicting the progression of Parkinson’s disease MDS-UPDRS-III motor severity score from gait data using deep learning. In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2021, pp. 249–252 (2021)

    Google Scholar 

  23. Chen, F., Fan, X., Li, J., Zou, M., Huang, L.: Gait analysis based Parkinson’s disease auxiliary diagnosis system. J. Internet Technol. 22(5), 991–999 (2021). Web 26 Feb. 2023

    Google Scholar 

  24. Setiawan, F., Lin, C.-W.: Implementation of a deep learning algorithm based on vertical ground reaction force time-frequency features for the detection and severity classification of Parkinson’s disease. Sensors (Basel, Switzerland) 21(15) 5207 (2021)

    Google Scholar 

  25. Papadopoulos, A., Iakovakis, D., Klingelhoefer, L., et al.: Unobtrusive detection of Parkinson’s disease from multi-modal and in-the-wild sensor data using deep learning techniques. Sci. Rep. 10, 21370 (2020)

    Article  Google Scholar 

  26. Aşuroğlu, T., Oğul, H.: A deep learning approach for Parkinson’s disease severity assessment. Health Technol. 12, 943–953 (2022)

    Article  Google Scholar 

  27. Zhao, A., et al.: A hybrid spatio-temporal model for detection and severity rating of Parkinson’s disease from gait data. Neurocomputing 315, 1–8 (2018)

    Google Scholar 

  28. Yang, X., Ye, Q., Cai, G., Wang, Y., Cai, G.: PD-ResNet for classification of Parkinson’s disease from gait. IEEE J. Transl. Eng. Health Med. 10, 2200111 (2022)

    Google Scholar 

  29. Balaji, E., Brindha, D., Elumalai, V.K., Vikrama, R.: Automatic and non-invasive Parkinson’s disease diagnosis and severity rating using LSTM network. Appl. Soft Comput. 108 (2021)

    Google Scholar 

  30. Bobić, V., Djurić-Jovičić, M., Dragašević, N., Popović, M.B., Kostić, V.S., Kvaščev, G.: An expert system for quantification of bradykinesia based on wearable inertial sensors. Sensors. 19(11), 2644 (2019)

    Article  Google Scholar 

  31. Bot, B., Suver, C., Neto, E., et al.: The mPower study, Parkinson disease mobile data collected using ResearchKit. Sci. Data 3, 160011 (2016)

    Article  Google Scholar 

  32. Kotsiantis, S., Kanellopoulos, D., Pintelas, P.: Data preprocessing for supervised leaning. World Academy of Science, Engineering and Technology, Open Science Index 12. Int. J. Comput. Inf. Eng. 1(12), 4104–4109 (2007)

    Google Scholar 

  33. Misra, P., Yadav, A.S.: Impact of preprocessing methods on healthcare predictions. In: ICACSE 2019: Proceedings (2019)

    Google Scholar 

  34. Abadi, M., Agarwal, A., et al.: Large-scale machine learning on heterogeneous systems (2015)

    Google Scholar 

  35. Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. CoRR abs/1412.6980 (2014)

    Google Scholar 

Download references

Acknowledgements

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No GA101017558.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nikos Tsolakis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 IFIP International Federation for Information Processing

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Tsolakis, N., Maga-Nteve, C., Meditskos, G., Vrochidis, S., Kompatsiaris, I. (2023). Ince-PD Model for Parkinson’s Disease Prediction Using MDS-UPDRS I & II and PDQ-8 Score. In: Maglogiannis, I., Iliadis, L., MacIntyre, J., Dominguez, M. (eds) Artificial Intelligence Applications and Innovations. AIAI 2023. IFIP Advances in Information and Communication Technology, vol 675. Springer, Cham. https://doi.org/10.1007/978-3-031-34111-3_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-34111-3_23

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-34110-6

  • Online ISBN: 978-3-031-34111-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics