Skip to main content

Medical Knowledge Extraction from Graph-Based Modeling of Electronic Health Records

  • Conference paper
  • First Online:
Artificial Intelligence Applications and Innovations (AIAI 2023)

Abstract

The variety and dimensionality of health-related data cannot be addressed by the human perception to arrive at useful knowledge or conclusions for proposing individualized treatment, diagnosis, or prognosis for a disease. Treating this wealth of heterogeneous data in a tabular manner deprives us of the knowledge that is hidden in interactions between the different types of data. In this paper, the potentials of graph-based data modeling and management are explored. Entities such as patients, encounters, observations, and immunizations are structured as graph elements with meaningful connections and are, consequently, encoded to form graph embeddings. The graph embeddings contain information about the graph structure in the vicinity of the node. This vicinity contains multiple low-level graph embeddings that are further encoded into a single high-level vector for utilization in downstream tasks by applying higher-order statistics on Gaussian Mixture Models With reference to the Covid-19 pandemic, we make use of synthetic data for predicting the risk of a patient’s fatality with a focus to prevent hospital overpopulation. Initial results demonstrate that utilizing networks of health data entities for the generation of compact medical representations has a positive impact on the performance of machine learning tasks. Since the generated Electronic Health Record vectors are label independent, they can be utilized for any classification or clustering task words.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ghassemi, M., Naumann, T., Schulam, P., Beam, A.L., Chen, I.Y., Ranganath, R.: A review of challenges and opportunities in machine learning for health. AMIA Jt Summits Transl, Sci, Proc, 2020, 191–200 (2020)

    Google Scholar 

  2. Xiao, C., Choi, E., Sun, J.: Opportunities and challenges in developing deep learning models using electronic health records data: a systematic review. J. Am. Med. Inf. Assoc.: JAMIA 25, 1419–1428 (Oct2018)

    Article  Google Scholar 

  3. Lee, D., Jiang, X., Yu, H.: Harmonized representation learning on dynamic EHR graphs. J. Biomed. Inform. 106, 103426 (2020)

    Article  Google Scholar 

  4. Poongodi, T., Sumathi, D., Suresh, P., Balusamy, B.: Deep learning techniques for electronic health record (EHR) analysis. In: Bhoi, A.K., Mallick, P.K., Liu, C.-M., Balas, V.E. (eds.) Bio-inspired Neurocomputing. SCI, vol. 903, pp. 73–103. Springer, Singapore (2021). https://doi.org/10.1007/978-981-15-5495-7_5

    Chapter  Google Scholar 

  5. Dong, Y., Chawla, N.V., Swami, A.: Metapath2vec: scalable representation learning for heterogeneous networks. In: Proceedings of the 23rd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD 2017). Association for Computing Machinery, New York (2017)

    Google Scholar 

  6. Perronnin, F., Dance, C.: Fisher Kernels on Visual Vocabularies for Image Categorization. In: 2007 IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–8 (2007)

    Google Scholar 

  7. Solares, J.R.A., et al.: Deep learning for electronic health records: a comparative review of multiple deep neural architectures. J. Biomed. Inf. 101, 103337 (2020)

    Article  Google Scholar 

  8. Grohe, M.: Word2vec, node2vec, graph2vec, X2vec: towards a theory of vector embeddings of structured data. In: Proceedings of the 39th ACM SIGMOD-SIGACT-SIGAI Symposium on Principles of Database Systems (PODS 2020) , pp. 1–16. Association for Computing Machinery, New York (2020)

    Google Scholar 

  9. Grover, A., Leskovec, J.: node2vec: scalable feature learning for networks. In: KDD : proceedings. International Conference on Knowledge Discovery & Data Mining, vol. 2016, pp. 855–864 (2016)

    Google Scholar 

  10. Velickovic, P., Fedus, W., Hamilton, W.L., Lio’, P., Bengio, Y., Hjelm, R.D.: Deep Graph Infomax. ArXiv, abs/1809.10341 (2019)

    Google Scholar 

  11. Kipf, T., Welling, M.: Semi-Supervised Classification with Graph Convolutional Networks. ArXiv, abs/1609.02907 (2017)

    Google Scholar 

  12. Velickovic, P., Cucurull, G., Casanova, A., Romero, A., Lio’, P., Bengio, Y.: Graph Attention Networks. ArXiv, abs/1710.10903 (2018)

    Google Scholar 

  13. Klicpera, J., Bojchevski, A., Günnemann, S.: Predict then propagate: graph neural networks meet personalized PageRank. In: ICLR (2019)

    Google Scholar 

  14. Hamilton, W.L., Ying, Z., Leskovec J.: Inductive representation learning on large graphs. In: NIPS (2017)

    Google Scholar 

  15. Schlichtkrull, M., Kipf, T., Bloem, P., Berg, R.V., Titov, I., Welling, M.: Modeling Relational Data with Graph Convolutional Networks. ArXiv, abs/1703.06103 (2018)

    Google Scholar 

  16. Chiang, W., Liu, X., Si, S., Li, Y., Bengio, S., Hsieh, C.: Cluster-GCN: an efficient algorithm for training deep and large graph convolutional networks. In: Proceedings of the 25th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining (2019)

    Google Scholar 

  17. Perozzi, B., Al-Rfou, R., Skiena, S.: DeepWalk: online learning of social representations. In: Proceedings of the 20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD 2014) , pp. 701–710. Association for Computing Machinery, New York (2014)

    Google Scholar 

  18. Le, Q., Mikolov, T.: Distributed representations of sentences and documents. In: Proceedings of the 31st International Conference on International Conference on Machine Learning, vol. 32, pp. II-1188–II-1196 (2014)

    Google Scholar 

  19. Bojanowski, P., Grave, E., Joulin, A., Mikolov, T.: Enriching Word Vectors with Subword Information. Trans. Assoc. Comput. Linguist. 5, 135–146 (July2016)

    Article  Google Scholar 

  20. Walonoski, J., et al.: Synthea™ novel coronavirus (COVID-19) model and synthetic data set. Intell.-Based Med. 1, 100007 (2020)

    Article  Google Scholar 

Download references

Acknowledgment

This research has been co‐financed by the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship, and Innovation, under the call RESEARCH – CREATE –INNOVATE (project code: MediLudus - Personalized home care based on research has based on game and gamified elements T1EDK-03049).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Athanasios Kallipolitis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 IFIP International Federation for Information Processing

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Kallipolitis, A., Gallos, P., Menychtas, A., Tsanakas, P., Maglogiannis, I. (2023). Medical Knowledge Extraction from Graph-Based Modeling of Electronic Health Records. In: Maglogiannis, I., Iliadis, L., MacIntyre, J., Dominguez, M. (eds) Artificial Intelligence Applications and Innovations. AIAI 2023. IFIP Advances in Information and Communication Technology, vol 675. Springer, Cham. https://doi.org/10.1007/978-3-031-34111-3_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-34111-3_24

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-34110-6

  • Online ISBN: 978-3-031-34111-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics