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Effect of Varying Pericardial Boundary Conditions on Whole Heart Function: A Computational Study

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Functional Imaging and Modeling of the Heart (FIMH 2023)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 13958))

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Abstract

Pericardiectomy is recommended therapy for pericarditis, an inflammation of the pericardial layers that surround the heart and play a central role in maintaining cardiac performance. In some cases, the pericardium can be repaired or patched. However, the impact of changes in the pericardium on cardiac function is not clear. The objective of this study is to analyze the effect of the pericardium on whole-heart function by varying normal Robin boundary conditions (BCs) applied on the ventricular epicardium. A piece-wise linear penalty function was defined using two parameters that were varied to describe the regional scaling of normal spring stiffness from apex to base. Gaussian process emulators were used to perform a global sensitivity analysis on how the varying pericardial BCs affect cardiac biomechanics in four-chamber heart models. Our results have shown that pressure- and volume-derived biomarkers change by less than 25% due to variations in the pericardium, with more variation in the right ventricle compared to the left ventricle. On the other hand, measurements for systolic motion exhibited a range of variability greater than 100% of the baseline mean. We predict that the pericardium has limited impact on measures of global function but impacts measures of local cardiac biomechanics.

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Authors and Affiliations

  1. Cardiac Electromechanics Research Group, Biomedical Engineering Department, King’s College London, London, UK

    Justina Ghebryal, Cristobal Rodero, Rosie K. Barrows, Marina Strocchi & Steven A. Niederer

  2. Eindhoven University of Technology, Eindhoven, The Netherlands

    Justina Ghebryal

  3. Queen Mary University of London, London, UK

    Caroline H. Roney

  4. Institute of Biophysics, Medical University of Graz, Graz, Austria

    Christoph M. Augustin & Gernot Plank

  5. BioTechMed-Graz, Graz, Austria

    Christoph M. Augustin & Gernot Plank

Authors
  1. Justina Ghebryal
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  2. Cristobal Rodero
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  3. Rosie K. Barrows
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  4. Marina Strocchi
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  5. Caroline H. Roney
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  6. Christoph M. Augustin
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  7. Gernot Plank
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  8. Steven A. Niederer
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Corresponding author

Correspondence to Justina Ghebryal .

Editor information

Editors and Affiliations

  1. CREATIS, INSA-Lyon, University of Lyon, Lyon, France

    Olivier Bernard

  2. CREATIS, CNRS, University of Lyon, Lyon, France

    Patrick Clarysse

  3. CREATIS, IUF, University of Lyon, Lyon, France

    Nicolas Duchateau

  4. TIMC, Savoie Mont Blanc University, Chambéry, France

    Jacques Ohayon

  5. CREATIS, Jean Monnet University, Saint-Etienne, France

    Magalie Viallon

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Ghebryal, J. et al. (2023). Effect of Varying Pericardial Boundary Conditions on Whole Heart Function: A Computational Study. In: Bernard, O., Clarysse, P., Duchateau, N., Ohayon, J., Viallon, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2023. Lecture Notes in Computer Science, vol 13958. Springer, Cham. https://doi.org/10.1007/978-3-031-35302-4_56

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  • DOI: https://doi.org/10.1007/978-3-031-35302-4_56

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-35301-7

  • Online ISBN: 978-3-031-35302-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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