Abstract
Placenta Accreta Spectrum (PAS) can lead to high risks like excessive blood loss at the delivery. Therefore, prenatal screening with MRI is essential for delivery planning that ensures better clinical outcomes. For computer-aided PAS diagnosis, existing work mostly extracts radiomics features directly from ROI while ignoring the context information, or learns global semantic features with limited awareness of the focal area. Moreover, they usually select single or few MRI slices to represent the whole sequences, which can result in biased decisions. To deal with these issues, a novel end-to-end Hierarchical Attention and Contrastive Learning Network (HACL-Net) is proposed under the formulation of a multi-instance problem. Slice-level attention module is first designed to extract context-aware deep semantic features. These slice-wise features are then aggregated via the patient-level attention module into task-specific patient-wise representation for PAS prediction. A plug-and-play contrastive learning module is introduced to further improve the discriminating power of extracted features. Extensive experiments with ablation studies on a real clinical dataset show that HACL-Net can achieve state-of-the-art prediction performance with the effectiveness of each module.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Balntas, V., Riba, E., Ponsa, D., Mikolajczyk, K.: Learning local feature descriptors with triplets and shallow convolutional neural networks. In: Proceedings of the British Machine Vision Conference (BMVC), pp. 119.1-119.11 (2016)
Chopra, S., Hadsell, R., LeCun, Y.: Learning a similarity metric discriminatively, with application to face verification. In: 2005 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR 2005), vol. 1, pp. 539–546 (2005)
Cummins, C., Petoumenos, P., Wang, Z., Leather, H.: End-to-end deep learning of optimization heuristics. In: 2017 26th International Conference on Parallel Architectures and Compilation Techniques (PACT), pp. 219–232. IEEE (2017)
Han, M., et al.: Automatic segmentation of human placenta images with u-net. IEEE Access 7, 180083–180092 (2019)
Ilse, M., Tomczak, J., Welling, M.: Attention-based deep multiple instance learning. In: International Conference on Machine Learning, pp. 2127–2136. PMLR (2018)
Jiao, M., Liu, H., Liu, J., Ouyang, H., Wang, X., Jiang, L., Yuan, H., Qian, Y.: Mal: Multi-modal attention learning for tumor diagnosis based on bipartite graph and multiple branches. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds.) MICCAI 2022. LNCS, vol. 13433, pp. 175–185. Springer, Cham (2022). https://doi.org/10.1007/978-3-031-16437-8_17
Kohli, M., Prevedello, L.M., Filice, R.W., Geis, J.R.: Implementing machine learning in radiology practice and research. Am. J. Roentgenol. 208(4), 754–760 (2017)
Li, H., Chen, L., Han, H., Kevin Zhou, S.: Satr: slice attention with transformer for universal lesion detection. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds.) MICCAI 2022. LNCS, pp. 163–174. Springer Nature Switzerland, Cham (2022)
Liu, X., et al.: What we know about placenta accreta spectrum (PAS). Eur. J. Obstet. Gynecol. Reprod. Biol. 259, 81–89 (2021)
Oyelese, Y., Smulian, J.C.: Placenta previa, placenta accreta, and vasa previa. Obstet. Gynecol. 107(4), 927–941 (2006)
Ren, H., et al.: Prediction of placenta accreta spectrum using texture analysis on coronal and sagittal T2-weighted imaging. Abdom. Radiol. 46, 5344–5352 (2021)
Romeo, V., et al.: Machine learning analysis of MRI-derived texture features to predict placenta accreta spectrum in patients with placenta previa. Magn. Reson. Imaging 64, 71–76 (2019)
Romeo, V., et al.: Prediction of placenta accreta spectrum in patients with placenta previa using clinical risk factors, ultrasound and magnetic resonance imaging findings. Radiol. Med. (Torino) 126(9), 1216–1225 (2021). https://doi.org/10.1007/s11547-021-01348-6
Ronneberger, O., Fischer, P., Brox, T.: U-net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Silver, R.M., Lyell, D.J.: Placenta accreta spectrum. Protocols for High-Risk Pregnancies: an evidence-based approach, pp. 571–580 (2020)
Tian, Y., et al.: Contrastive transformer-based multiple instance learning for weakly supervised polyp frame detection. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds.) MICCAI 2022. LNCS, pp. 88–98. Springer Nature Switzerland, Cham (2022). https://doi.org/10.1007/978-3-031-16437-8_9
Van Griethuysen, J.J., et al.: Computational radiomics system to decode the radiographic phenotype. Can. Res. 77(21), e104–e107 (2017)
Wang, F., et al.: Residual attention network for image classification. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3156–3164 (2017)
Wang, S., et al.: RMDL: recalibrated multi-instance deep learning for whole slide gastric image classification. Med. Image Anal. 58, 101549 (2019)
Xuan, R., Li, T., Wang, Y., Xu, J., Jin, W.: Prenatal prediction and typing of placental invasion using MRI deep and radiomic features. Biomed. Eng. Online 20(1), 56 (2021)
Yao, J., Zhu, X., Huang, J.: Deep multi-instance learning for survival prediction from whole slide images. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11764, pp. 496–504. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32239-7_55
Yao, J., Zhu, X., Jonnagaddala, J., Hawkins, N., Huang, J.: Whole slide images based cancer survival prediction using attention guided deep multiple instance learning networks. Med. Image Anal. 65, 101789 (2020)
Ye, Z., Xuan, R., Ouyang, M., Wang, Y., Xu, J., Jin, W.: Prediction of placenta accreta spectrum by combining deep learning and radiomics using t2wi: a multicenter study. Abdominal Radiol. 47(12), 4205–4218 (2022)
Zhang, D., Zou, L., Zhou, X., He, F.: Integrating feature selection and feature extraction methods with deep learning to predict clinical outcome of breast cancer. IEEE Access 6, 28936–28944 (2018)
Zhang, Y., et al.: Spatiotemporal attention for early prediction of hepatocellular carcinoma based on longitudinal ultrasound images. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds.) MICCAI 2022. LNCS, vol. 13433, pp. 534–543. Springer, Cham (2022)
Acknowledgement
This research was supported by Dr. Hao Zhu’s team from Obstetrics and Gynecology Hospital affiliated to Fudan University in China.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
1 Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Lu, M., Wang, T., Zhu, H., Li, M. (2023). HACL-Net: Hierarchical Attention and Contrastive Learning Network for MRI-Based Placenta Accreta Spectrum Diagnosis. In: Greenspan, H., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2023. MICCAI 2023. Lecture Notes in Computer Science, vol 14226. Springer, Cham. https://doi.org/10.1007/978-3-031-43990-2_29
Download citation
DOI: https://doi.org/10.1007/978-3-031-43990-2_29
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-43989-6
Online ISBN: 978-3-031-43990-2
eBook Packages: Computer ScienceComputer Science (R0)