Abstract
Pathological complete response (pCR) after neoadjuvant che-motherapy (NAC) in patients with breast cancer was found to improve survival, and it has a great prognostic value in the aggressive tumor subtype. This study aims to predict pCR before NAC treatment with a radiomic feature-based ensemble learning model using both positron emission tomography/computed tomography (PET/CT) images taken from the online QIN-Breast dataset. It studies the problem of constructing an end-to-end classification pipeline that includes a large-scale radiomic feature extraction, a hybrid iterative feature selection and a heterogeneous weighted ensemble classification. The proposed hybrid feature selection procedure can identify significant radiomic predictors out of 2153 features extracted from delineated tumour regions. The proposed weighted ensemble approach aggregates the outcomes of four weak classifiers (Decision tree, Naive Bayes, K-nearest neighbour, and Logistics regression) based on their importance. The empirical study demonstrates that the proposed feature selection-cum-ensemble classification method has achieved 92% and 88.4% balanced accuracy in PET and CT, respectively. The PET/CT aggregated model performed better and achieved 98% balanced accuracy and 94.74% F1-score. Furthermore, this study is the first classification work on the online QIN-Breast dataset.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Boughdad, S., et al.: Early metabolic response of breast cancer to neoadjuvant endocrine therapy: comparison to morphological and pathological response. Cancer Imaging 20(1), 11 (2020)
Conti, A., Duggento, A., Indovina, I., Guerrisi, M., Toschi, N.: Radiomics in breast cancer classification and prediction. In: Seminars in Cancer Biology. Elsevier (2020)
Demšar, J.: Statistical comparisons of classifiers over multiple data sets. J. Mach. Learn. Res. 7, 1–30 (2006)
Dogan, A., Birant, D.: A weighted majority voting ensemble approach for classification. In: 2019 4th International Conference on Computer Science and Engineering (UBMK), pp. 1–6. IEEE (2019)
Dua, D., Graff, C.: UCI machine learning repository (2017)
Kaya, Y., Kuncan, F.: A hybrid model for classification of medical data set based on factor analysis and extreme learning machine: FA+ ELM. Biomed. Sign. Process. Control 78, 104023 (2022)
Kim, T., Lee, J.S.: Exponential loss minimization for learning weighted Naive Bayes classifiers. IEEE Access 10, 22724–22736 (2022)
Li, P., et al.: 18F-FDG PET/CT radiomic predictors of pathologic complete response (pCR) to neoadjuvant chemotherapy in breast cancer patients. Eur. J. Nuclear Med. Mol. Imaging 47(5), 1116–1126 (2020). https://doi.org/10.1007/s00259-020-04684-3
Li, X., Abramson, R.G., Arlinghaus, L.R.: Data from QIN-breast. The Cancer Imaging Archive (2016)
Matsuda, N., et al.: Change in sonographic brightness can predict pathological response of triple-negative breast cancer to neoadjuvant chemotherapy. Breast Cancer 25(1), 43–49 (2018)
Memiş, S., Enginoğlu, S., Erkan, U.: A classification method in machine learning based on soft decision-making via fuzzy parameterized fuzzy soft matrices. Soft. Comput. 26(3), 1165–1180 (2022)
Ou, X., et al.: Radiomics based on 18F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: a preliminary study. Cancer Med. 9(2), 496–506 (2020)
Pal, S.: Chronic kidney disease prediction using machine learning techniques. Biomed. Mater. Dev. 1–7 (2022)
Sung, H., et al.: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021)
Tanveer, M., Ganaie, M.A., Suganthan, P.N.: Ensemble of classification models with weighted functional link network. Appl. Soft Comput. 107, 107322 (2021)
Van Griethuysen, J.J.M., et al.: Computational radiomics system to decode the radiographic phenotype. Can. Res. 77(21), e104–e107 (2017)
Yang, L., et al.: Prediction model of the response to neoadjuvant chemotherapy in breast cancers by a Naive Bayes algorithm. Comp Meth. Programs Biomed. 192, 105458 (2020)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Dholey, M. et al. (2023). Ensemble Methods with [\(^{18}\)F]FDG-PET/CT Radiomics in Breast Cancer Response Prediction. In: Maji, P., Huang, T., Pal, N.R., Chaudhury, S., De, R.K. (eds) Pattern Recognition and Machine Intelligence. PReMI 2023. Lecture Notes in Computer Science, vol 14301. Springer, Cham. https://doi.org/10.1007/978-3-031-45170-6_38
Download citation
DOI: https://doi.org/10.1007/978-3-031-45170-6_38
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-45169-0
Online ISBN: 978-3-031-45170-6
eBook Packages: Computer ScienceComputer Science (R0)