Abstract
Developing fair and unbiased models is important for good scientific practice and clinical utility. This paper delves into the specific biases associated with artificial intelligence (AI) in neuroimaging research, and highlights the structural issues that underpin them. We propose a range of mitigation strategies, encompassing both behavioural and technical considerations. By recognising these challenges, we can encourage more accurate and equitable insights into neuroimaging research.
S. A. Martin, F. Biondo and B. Taylor—These authors contributed equally.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aghili, M., Tabarestani, S., Adjouadi, M.: Addressing the missing data challenge in multi-modal datasets for the diagnosis of Alzheimer’s disease. J. Neurosci. Methods 375, 109582 (2022)
Bethlehem, R.A.I., et al.: Brain charts for the human lifespan. Nature 604(7906), 525–533 (2022)
Bhopal, K.: Gender, ethnicity and career progression in UK higher education: a case study analysis. Res. Pap. Educ. 35(6), 706–721 (2020)
Biondo, F., et al.: Brain-age is associated with progression to dementia in memory clinic patients. NeuroImage Clin. 36, 103175 (2022)
Cameron, J.J., Stinson, D.A.: Gender (mis)measurement: Guidelines for respecting gender diversity in psychological research. Soc. Pers. Psychol. Compass 13(11), e12506 (2019)
Carneiro, D., Veloso, P.: Ethics, transparency, fairness and the responsibility of artificial intelligence. In: de Paz Santana, J.F., de la Iglesia, D.H., López Rivero, A.J. (eds.) DiTTEt 2021. AISC, vol. 1410, pp. 109–120. Springer, Cham (2022). https://doi.org/10.1007/978-3-030-87687-6_12
Chen, I.Y., et al.: Ethical machine learning in healthcare. Ann. Rev. Biomed. Data Sci. 4(1), 123–144 (2021)
Chen, Z., et al.: Evaluation of risk of bias in neuroimaging-based artificial intelligence models for psychiatric diagnosis: a systematic review. JAMA Netw. Open 6(3), e231671–e231671 (2023)
Diedrichsen, J., et al.: A probabilistic MR atlas of the human cerebellum. Neuroimage 46(1), 39–46 (2009)
Drukker, K., et al.: Toward fairness in artificial intelligence for medical image analysis: identification and mitigation of potential biases in the roadmap from data collection to model deployment. J. Med. Imaging 10(6), 061104 (2023)
Duncan, N.W.: Geographical and economic influences on neuroimaging modality choice. Center for Open Science (2023)
Fabbri, A., et al.: The influence of industry sponsorship on the research agenda: a scoping review. Am. J. Public Health 108(11), e9–e16 (2018)
Fry, A., et al.: Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population. Am. J. Epidemiol. 186(9), 1026–1034 (2017)
Ganguli, M., et al.: Who wants a free brain scan? Assessing and correcting for recruitment biases in a population-based sMRI pilot study. Brain Imaging Behav. 9(2), 204–212 (2015)
Henrich, J., Heine, S.J., Norenzayan, A.: The weirdest people in the world? Behav. Brain Sci. 33(2–3), 61–83 (2010)
Hlávka, J.P.: Chapter 10 - Security, Privacy, and Information-Sharing Aspects of Healthcare Artificial Intelligence, pp. 235–270. Academic Press (2020)
Hoddinott, P., et al.: How to incorporate patient and public perspectives into the design and conduct of research. F1000Res 7, 752 (2018)
Holla, B., et al.: A series of five population-specific Indian brain templates and atlases spanning ages 6–60 years. Hum. Brain Mapp. 41(18), 5164–5175 (2020)
Hui, A., et al.: Exploring the impacts of organisational structure, policy and practice on the health inequalities of marginalised communities: Illustrative cases from the UK healthcare system. Health Policy 124(3), 298–302 (2020)
Iglesias, J.E., et al.: SynthSR: a public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry. Sci. Adv. 9(5), eadd3607 (2023)
Kenfack, P.J., et al.: Learning fair representations through uniformly distributed sensitive attributes. In: 2023 IEEE Conference on Secure and Trustworthy Machine Learning (SaTML), pp. 58–67 (2023)
Kusnoor, S.V., et al.: Design and implementation of a massive open online course on enhancing the recruitment of minorities in clinical trials - faster together. BMC Med. Res. Methodol. 21(1), 1–11 (2021)
Lara, M.A.R., et al.: Addressing fairness in artificial intelligence for medical imaging. Nat. Commun. 13(1), 4581 (2022)
Longino, H.E.: The Fate of Knowledge. The Fate of Knowledge. Princeton University Press, Princeton (2002)
McLane, H.C., et al.: Availability, accessibility, and affordability of neurodiagnostic tests in 37 countries. Neurology 85(18), 1614–22 (2015)
Moseson, H., et al.: The imperative for transgender and gender nonbinary inclusion: beyond women’s health. Obstet. Gynecol. 135(5), 1059–1068 (2020)
Murray, D.L., et al.: Bias in research grant evaluation has dire consequences for small universities. PLoS ONE 11(6), e0155876 (2016)
Natale, V., Rajagopalan, A.: Worldwide variation in human growth and the World Health Organization growth standards: a systematic review. BMJ Open 4(1), e003735 (2014)
Ricard, J.A., et al.: Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data. Nat. Neurosci. 26(1), 4–11 (2023)
Rieke, N., et al.: The future of digital health with federated learning. NPJ Dig. Med. 3(1), 119 (2020)
Showunmi, V.: Visible, invisible: Black women in higher education. Front. Sociol. 8, 974617 (2023)
Starke, G., De Clercq, E., Elger, B.S.: Towards a pragmatist dealing with algorithmic bias in medical machine learning. Med. Health Care Philos. 24(3), 341–349 (2021). https://doi.org/10.1007/s11019-021-10008-5
Suresh, H., Guttag, J.: A framework for understanding sources of harm throughout the machine learning life cycle. Association for Computing Machinery (2021)
The MIT Press: A conversation with Dr. Stephen M. Smith, editor-in-chief of imaging neuroscience (2023). https://mitpress.mit.edu/a-conversation-with-dr-stephen-m-smith-editor-in-chief-of-imaging-neuroscience/
UKRI: Consequences of the 2021 ODA Budget Cuts: Key Findings. UKRI ODA Review (2022). https://www.ukri.org/publications/consequences-of-the-2021-oda-budget-cuts-key-findings-report/
Wald, L.L., et al.: Low-cost and portable MRI. J. Magn. Reson. Imaging 52(3), 686–696 (2020)
Wee, C.Y., et al.: Cortical graph neural network for AD and MCI diagnosis and transfer learning across populations. NeuroImage Clin. 23, 101929 (2019)
Wen, J., et al.: Convolutional neural networks for classification of Alzheimer’s disease: overview and reproducible evaluation. Med. Image Anal. 63, 101694 (2020)
Wiener, M., Sommer, F.T., Ives, Z.G., Poldrack, R.A., Litt, B.: Enabling an open data ecosystem for the neurosciences. Neuron 92(3), 617–621 (2016)
Acknowledgements
We would like to thank members of the Centre for Medical Image Computing, UCL and the Dementia Research Centre, UCL, for interesting and insightful discussions which helped shape this work.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Martin, S.A., Biondo, F., Cole, J.H., Taylor, B. (2023). Brain Matters: Exploring Bias in AI for Neuroimaging Research. In: Wesarg, S., et al. Clinical Image-Based Procedures, Fairness of AI in Medical Imaging, and Ethical and Philosophical Issues in Medical Imaging. CLIP EPIMI FAIMI 2023 2023 2023. Lecture Notes in Computer Science, vol 14242. Springer, Cham. https://doi.org/10.1007/978-3-031-45249-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-031-45249-9_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-45248-2
Online ISBN: 978-3-031-45249-9
eBook Packages: Computer ScienceComputer Science (R0)