Abstract
Recent studies showed the possibility of extracting SoS information from pulse-echo ultrasound raw data (a.k.a. RF data) using deep neural networks that are fully trained on simulated data. These methods take sensor domain data, i.e., RF data, as input and train a network in an end-to-end fashion to learn the implicit mapping between the RF data domain and the SoS domain. However, such networks are prone to overfitting to simulated data which results in poor performance and instability when tested on measured data. We propose a novel method for SoS mapping employing learned representations from two linked autoencoders. We test our approach on simulated and measured data acquired from human breast mimicking phantoms. We show that SoS mapping is possible using the learned representations by linked autoencoders. The proposed method has a Mean Absolute Percentage Error (MAPE) of \(2.39\%\) on the simulated data. On the measured data, the predictions of the proposed method are close to the expected values (MAPE of \(1.1\) \(\%\)). Compared to an end-to-end trained network, the proposed method shows higher stability and reproducibility.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Antun, V., Renna, F., Poon, C., Adcock, B., Hansen, A.C.: On instabilities of deep learning in image reconstruction and the potential costs of AI. Proc. Natl. Acad. Sci. 117(48), 30088–30095 (2020)
Bengio, Y.: Learning Deep Architectures for AI. Now Publishers Inc. (2009)
Bengio, Y., Courville, A., Vincent, P.: Representation learning: a review and new perspectives. IEEE Trans. Pattern Anal. Mach. Intell. 35(8), 1798–1828 (2013)
Chen, M., Shi, X., Zhang, Y., Wu, D., Guizani, M.: Deep features learning for medical image analysis with convolutional autoencoder neural network. IEEE Trans. Big Data 7, 750–758 (2017)
Feigin, M., Freedman, D., Anthony, B.W.: A deep learning framework for single-sided sound speed inversion in medical ultrasound. IEEE Trans. Biomed. Eng. 67(4), 1142–1151 (2019)
Feigin, M., Zwecker, M., Freedman, D., Anthony, B.W.: Detecting muscle activation using ultrasound speed of sound inversion with deep learning. In: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), pp. 2092–2095. IEEE (2020)
Fu, W., Breininger, K., Schaffert, R., Ravikumar, N., Maier, A.: A divide-and-conquer approach towards understanding deep networks. In: Shen, D., et al. (ed.) Medical Image Computing and Computer Assisted Intervention, MICCAI 2019. LNCS, vol. 11764, pp. 183–191. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32239-7_21
Fu, W., Husvogt, L., Ploner, S., Fujimoto, J.G., Maier, A.: Modularization of deep networks allows cross-modality reuse. In: Bildverarbeitung für die Medizin 2020. I, pp. 274–279. Springer, Wiesbaden (2020). https://doi.org/10.1007/978-3-658-29267-6_61
Hager, P.A., Khun Jush, F., Biele, M., Düppenbecker, P.M., Schmidt, O., Benini, L.: LightABVS: a digital ultrasound transducer for multi-modality automated breast volume scanning. In: 2019 IEEE International Ultrasonics Symposium (IUS) (2019)
Heller, M., Schmitz, G.: Deep learning-based speed-of-sound reconstruction for single-sided pulse-echo ultrasound using a coherency measure as input feature. In: 2021 IEEE International Ultrasonics Symposium (IUS), pp. 1–4. IEEE (2021)
Hill, C.R., Bamber, J.C., ter Haar, G.R.: Physical Principles of Medical Ultrasonics (2004)
Khun Jush, F., Biele, M., Dueppenbecker, P.M., Maier, A.: Deep learning for ultrasound speed-of-sound reconstruction: impacts of training data diversity on stability and robustness. MELBA J. Mach. Learn. Biomed. Imaging 2, 202–236 (2023)
Khun Jush, F., Biele, M., Dueppenbecker, P.M., Schmidt, O., Maier, A.: DNN-based speed-of-sound reconstruction for automated breast ultrasound. In: 2020 IEEE International Ultrasonics Symposium (IUS), pp. 1–7. IEEE (2020)
Khun Jush, F., Dueppenbecker, P.M., Maier, A.: Data-driven speed-of-sound reconstruction for medical ultrasound: impacts of training data format and imperfections on convergence. In: Papież, B.W., Yaqub, M., Jiao, J., Namburete, A.I.L., Noble, J.A. (eds.) MIUA 2021. LNCS, vol. 12722, pp. 140–150. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-80432-9_11
Li, C., Duric, N., Littrup, P., Huang, L.: In vivo breast sound-speed imaging with ultrasound tomography. Ultrasound Med. Biol. 35(10), 1615–1628 (2009)
Maier, A., Köstler, H., Heisig, M., Krauss, P., Yang, S.H.: Known operator learning and hybrid machine learning in medical imaging - a review of the past, the present, and the future. Prog. Biomed. Eng. 4, 022002 (2022)
Maier, A., et al.: Precision learning: towards use of known operators in neural networks. In: 2018 24th International Conference on Pattern Recognition (ICPR), pp. 183–188. IEEE (2018)
Maier, A., Syben, C., Lasser, T., Riess, C.: A gentle introduction to deep learning in medical image processing. Z. Med. Phys. 29(2), 86–101 (2019)
Maier, A.K., et al.: Learning with known operators reduces maximum error bounds. Nat. Mach. Intell. 1(8), 373–380 (2019)
Masci, J., Meier, U., Cireşan, D., Schmidhuber, J.: Stacked convolutional auto-encoders for hierarchical feature extraction. In: Honkela, T., Duch, W., Girolami, M., Kaski, S. (eds.) ICANN 2011. LNCS, vol. 6791, pp. 52–59. Springer, Heidelberg (2011). https://doi.org/10.1007/978-3-642-21735-7_7
Oh, S.H., Kim, M.-G., Kim, Y., Kwon, H., Bae, H.-M.: A neural framework for multi-variable lesion quantification through b-mode style transfer. In: de Bruijne, M., et al. (eds.) MICCAI 2021. LNCS, vol. 12906, pp. 222–231. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-87231-1_22
Ruby, L., et al.: Breast cancer assessment with pulse-echo speed of sound ultrasound from intrinsic tissue reflections: proof-of-concept. Invest. Radiol. 54(7), 419–427 (2019)
Sak, M., et al.: Using speed of sound imaging to characterize breast density. Ultrasound Med. Biol. 43(1), 91–103 (2017)
Sanabria, S.J., et al.: Breast-density assessment with hand-held ultrasound: a novel biomarker to assess breast cancer risk and to tailor screening? Eur. Radiol. 28(8), 3165–3175 (2018)
Sanabria, S.J., Rominger, M.B., Goksel, O.: Speed-of-sound imaging based on reflector delineation. IEEE Trans. Biomed. Eng. 66(7), 1949–1962 (2018)
Schreiman, J., Gisvold, J., Greenleaf, J.F., Bahn, R.: Ultrasound transmission computed tomography of the breast. Radiology 150(2), 523–530 (1984)
Stähli, P., Frenz, M., Jaeger, M.: Bayesian approach for a robust speed-of-sound reconstruction using pulse-echo ultrasound. IEEE Trans. Med. Imaging 40(2), 457–467 (2020)
Stähli, P., Kuriakose, M., Frenz, M., Jaeger, M.: Improved forward model for quantitative pulse-echo speed-of-sound imaging. Ultrasonics 108, 106168 (2020)
Treeby, B.E., Cox, B.T.: k-Wave: MATLAB toolbox for the simulation and reconstruction of photoacoustic wave fields. J. Biomed. Opt. 15(2), 021314 (2010)
Vincent, P., Larochelle, H., Bengio, Y., Manzagol, P.A.: Extracting and composing robust features with denoising autoencoders. In: Proceedings of the 25th International Conference on Machine Learning, pp. 1096–1103 (2008)
Vishnevskiy, V., Sanabria, S.J., Goksel, O.: Image reconstruction via variational network for real-time hand-held sound-speed imaging. In: Knoll, F., Maier, A., Rueckert, D. (eds.) MLMIR 2018. LNCS, vol. 11074, pp. 120–128. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00129-2_14
Zhu, B., Liu, J.Z., Cauley, S.F., Rosen, B.R., Rosen, M.S.: Image reconstruction by domain-transform manifold learning. Nature 555(7697), 487–492 (2018)
Zhu, J.Y., Park, T., Isola, P., Efros, A.A.: Unpaired image-to-image translation using cycle-consistent adversarial networks. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2223–2232 (2017)
Acknowledgments
We thank Prof. Michael Golatta and the university hospital of Heidelberg for providing the Tomosynthesis dataset.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Khun Jush, F., Dueppenbecker, P.M., Maier, A. (2024). Speed-of-Sound Mapping for Pulse-Echo Ultrasound Raw Data Using Linked-Autoencoders. In: Maier, A.K., Schnabel, J.A., Tiwari, P., Stegle, O. (eds) Machine Learning for Multimodal Healthcare Data. ML4MHD 2023. Lecture Notes in Computer Science, vol 14315. Springer, Cham. https://doi.org/10.1007/978-3-031-47679-2_8
Download citation
DOI: https://doi.org/10.1007/978-3-031-47679-2_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-47678-5
Online ISBN: 978-3-031-47679-2
eBook Packages: Computer ScienceComputer Science (R0)