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A Purified Stacking Ensemble Framework for Cytology Classification

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MultiMedia Modeling (MMM 2024)

Abstract

Cancer is one of the fatal threats to human beings. However, early detection and diagnosis can significantly reduce death risk, in which cytology classification is indispensable. Researchers have proposed many deep learning-based methods for automated cancer diagnosis. Nevertheless, due to the similarity of pathological features in cytology images and the scarcity of high-quality datasets, neither the limited accuracy of single networks nor the complex architectures of ensemble methods can meet practical application needs. To address the issue, we propose a purified Stacking ensemble framework, which employs three homogeneous convolutional neural networks (CNNs) as base learners and integrates their outputs to generate a new dataset by a k-fold split and concatenation strategy. Then a distance weighted voting technique is applied to purify the dataset, on which a multinomial logistic regression model with a designed loss function is trained as the meta-learner and performs the final predictions. The method is evaluated on the FNAC, Ascites, and SIPaKMeD datasets, achieving accuracies of 99.85%, 99.24%, and 99.75%, respectively. The experimental results outperform the current state-of-the-art (SOTA) methods, demonstrating its potential for reducing screening workload and helping pathologists detect cancer.

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References

  1. Alberts, B., et al.: Essential cell biology. Garland Science (2015)

    Google Scholar 

  2. Morrison, W., DeNicola, D.: Advantages and disadvantages of cytology and histopathology for the diagnosis of cancer. In: Seminars in veterinary medicine and surgery (small animal), vol. 8, pp. 222–227 (1993)

    Google Scholar 

  3. Jantzen, J., Norup, J., Dounias, G., Bjerregaard, B.: Pap-smear benchmark data for pattern classification. Nature inspired Smart Information Systems (NiSIS 2005), pp. 1–9 (2005)

    Google Scholar 

  4. Zhang, C., Liu, D., Wang, L., Li, Y., Chen, X., Luo, R., Che, S., Liang, H., Li, Y., Liu, S., Tu, D., Qi, G., Luo, P., Luo, J.: DCCL: a benchmark for cervical cytology analysis. In: Suk, H.-I., Liu, M., Yan, P., Lian, C. (eds.) MLMI 2019. LNCS, vol. 11861, pp. 63–72. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32692-0_8

    Chapter  Google Scholar 

  5. Teramoto, A., et al.: Automated classification of benign and malignant cells from lung cytological images using deep convolutional neural network. Inf. Med. Unlocked 16, 100205 (2019)

    Article  Google Scholar 

  6. Zhang, L., Lu, L., Nogues, I., Summers, R.M., Liu, S., Yao, J.: Deeppap: deep convolutional networks for cervical cell classification. IEEE J. Biomed. Health Inform. 21(6), 1633–1643 (2017)

    Article  Google Scholar 

  7. Tripathi, A., Arora, A., Bhan, A.: Classification of cervical cancer using deep learning algorithm. In: 2021 5th International Conference on Intelligent Computing and Control Systems (ICICCS), pp. 1210–1218. IEEE (2021)

    Google Scholar 

  8. Sagi, O., Rokach, L.: Ensemble learning: a survey. Wiley Interdisciplinary Rev. Data Mining Knowl. Discovery 8(4), e1249 (2018)

    Google Scholar 

  9. Ghiasi, M.M., Zendehboudi, S.: Application of decision tree-based ensemble learning in the classification of breast cancer. Comput. Biol. Med. 128, 104089 (2021)

    Article  Google Scholar 

  10. Manna, A., Kundu, R., Kaplun, D., Sinitca, A., Sarkar, R.: A fuzzy rank-based ensemble of cnn models for classification of cervical cytology. Sci. Rep. 11(1), 14538 (2021)

    Article  Google Scholar 

  11. Wolpert, D.H.: Stacked generalization. Neural Netw. 5(2), 241–259 (1992)

    Article  Google Scholar 

  12. Saikia, A.R., Bora, K., Mahanta, L.B., Das, A.K.: Comparative assessment of CNN architectures for classification of breast FNAC images. Tissue Cell 57, 8–14 (2019)

    Article  Google Scholar 

  13. Su, F., et al.: Development and validation of a deep learning system for ascites cytopathology interpretation. Gastric Cancer 23, 1041–1050 (2020)

    Article  Google Scholar 

  14. Plissiti, M.E., Dimitrakopoulos, P., Sfikas, G., Nikou, C., Krikoni, O., Charchanti, A.: Sipakmed: a new dataset for feature and image based classification of normal and pathological cervical cells in pap smear images. In: 2018 25th IEEE International Conference on Image Processing (ICIP), pp. 3144–3148. IEEE (2018)

    Google Scholar 

  15. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

  16. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  17. Szegedy, C., et al.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015)

    Google Scholar 

  18. Tan, M., Le, Q.: Efficientnetv2: smaller models and faster training. In: International Conference on Machine Learning, pp. 10096–10106. PMLR (2021)

    Google Scholar 

  19. Liu, Z., Mao, H., Wu, C.Y., Feichtenhofer, C., Darrell, T., Xie, S.: A convnet for the 2020s. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 11976–11986 (2022)

    Google Scholar 

  20. Dey, S., Das, S., Ghosh, S., Mitra, S., Chakrabarty, S., Das, N.: SynCGAN: using learnable class specific priors to generate synthetic data for improving classifier performance on cytological images. In: Babu, R.V., Prasanna, M., Namboodiri, V.P. (eds.) NCVPRIPG 2019. CCIS, vol. 1249, pp. 32–42. Springer, Singapore (2020). https://doi.org/10.1007/978-981-15-8697-2_3

    Chapter  Google Scholar 

  21. Pramanik, R., Biswas, M., Sen, S., de Souza Júnior, L.A., Papa, J.P., Sarkar, R.: A fuzzy distance-based ensemble of deep models for cervical cancer detection. Comput. Methods Programs Biomed. 219, 106776 (2022)

    Article  Google Scholar 

  22. Nanni, L., Ghidoni, S., Brahnam, S., Liu, S., Zhang, L.: Ensemble of handcrafted and deep learned features for cervical cell classification. Deep Learners and Deep Learner Descriptors for Medical Applications, pp. 117–135 (2020)

    Google Scholar 

  23. Basak, H., Kundu, R., Chakraborty, S., Das, N.: Cervical cytology classification using pca and gwo enhanced deep features selection. SN Comput. Sci. 2(5), 369 (2021)

    Article  Google Scholar 

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Acknowledgements

This paper was supported by the Key Research and Development Program of Yunnan Province under grant no. 202203AA080009, the 14th Five-Year Plan for Educational Science of Jiangsu Province under grant no. D/2021/01/39, and the Jiangsu Higher Education Reform Research Project “Research on the Evaluation of Practical Teaching Reform in Information Majors based on Student Practical Ability Model” under grant no. 2021JSJG143.

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Qian, L., Huang, Q., Chen, Y., Chen, J. (2024). A Purified Stacking Ensemble Framework for Cytology Classification. In: Rudinac, S., et al. MultiMedia Modeling. MMM 2024. Lecture Notes in Computer Science, vol 14555. Springer, Cham. https://doi.org/10.1007/978-3-031-53308-2_20

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  • DOI: https://doi.org/10.1007/978-3-031-53308-2_20

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-031-53308-2

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