Abstract
In this paper, we are aiming to propose a novel mathematical model that studies the dynamics of synaptic damage in terms of concentrations of toxic neuropeptides (neurotransmitters) during neurotransmission processes. Our objective is to employ “Wardrop’s first and second principles” within a neural network of the brain. Complete manifestations of Wardrop’s first and second principles within a neural network of the brain are presented through the introduction of two novel concepts: neuropeptide’s (neurotransmitter’s) equilibrium and synapses optimum. In the context of a neural network within the brain, an analogue of the price of anarchy is the price of cognition which is the most unfavorable ratio between the overall impairment caused by toxic neuropeptide’s (neurotransmitter’s) equilibrium in comparison to the optimal state of synapses (synapses optimum). Finally, we also propose an iterative algorithm (neurodynamics) in which the synapses optimum is eventually established during the neurotransmission process. We envision that this mathematical model can serve as a source of motivation to instigate novel experimental and computational research avenues in the fields of artificial neural networks and contemporary neuroscience.
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References
Della Sala, S.: Encyclopedia of Behavioral Neuroscience, 2nd Ed., Elsevier Science, (2021)
Fauth, M., Wörgötter, F., Tetzlaff, C.: The formation of multi-synaptic connections by the interaction of synaptic and structural plasticity and their functional consequences. PLoS Comput. Biol. 11(1), 1–29 (2015)
Reddy, P.H.: A critical assessment of research on neurotransmitters in Alzheimer’s disease. J. Alzheimers Dis. 57(4), 969–974 (2017)
Rajmohan, R., Reddy, P.H.: Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. J. Alzheimers Dis. 57(4), 975–999 (2017)
Jha, S.K., et al.: Stress-induced synaptic dysfunction and neurotransmitter release in Alzheimer’s disease: can neurotransmitters and neuromodulators be potential therapeutic targets? J. Alzheimers Dis. 57(4), 1017–1039 (2017)
Wang, R., Reddy, P.H.: Role of glutamate and NMDA receptors in Alzheimer’s disease. J. Alzheimers Dis. 57(4), 1041–1048 (2017)
Kandimalla, R., Reddy, P.H.: Therapeutics of neurotransmitters in Alzheimer’s disease. J. Alzheimers Dis. 57(4), 1049–1069 (2017)
Guo, L., Tian, J., Du. H.: Mitochondrial dysfunction and synaptic transmission failure in Alzheimer’s disease. J. Alzheimers Dis. 57(4) 1071–1086 (2017)
Cai, Q., Tammineni, P.: Mitochondrial aspects of synaptic dysfunction in Alzheimer’s disease. J. Alzheimers Dis. 57(4), 1087–1103 (2017)
Tönnies, E., Trushina, E.: Oxidative stress, synaptic dysfunction, and Alzheimer’s disease. J. Alzheimers Dis. 57(4), 1105–1121 (2017)
Jiang, S., Bhaskar, K.: Dynamics of the complement, cytokine, and chemokine systems in the regulation of synaptic function and dysfunction relevant to Alzheimer’s disease. J. Alzheimers Dis. 57(4), 1123–1135 (2017)
Chen, K., Weng, Y., Hosseini, A.A., Dening, T., Zuo, G., Zhang, Y.: A comparative study of GNN and MLP based machine learning for the diagnosis of Alzheimer’s Disease involving data synthesis. Neural Netw. 169, 442–452 (2024)
Park, S., Hong, Ch.H., Lee, D-Gi., Park, K., Shin, H.: Prospective classification of Alzheimer’s disease conversion from mild cognitive impairment. Neural Networks 164, 335–344 (2023)
Ho, Ng-H., Yang, H.-J., Kim, J., Dao, D-Ph., Park, H.-R., Pant, S.: Predicting progression of Alzheimer’s disease using forward-to-backward bi-directional network with integrative imputation. Neural Networks 150, 422–439 (2022)
Wardrop, J.G.: Some theoretical aspects of road traffic research. Proc. Inst. Civil Eng. Part II 1(3), 325–362 (1952)
Beckmann, M., McGuir, C., Winsten, C.: Studies in Economics of Transportation. Yale University Press, New Haven (1956)
Dafermos, S.: Traffic Assignment and Resource Allocation in Transportation Networks. Ph.D. Thesis, The Johns Hopkins University (1968)
Dafermos, S., Sparrow, F.T.: Traffic assignment problem for a general network. J. Res. Natl. Bureau Standards, Sect. B: Math. Sci. 73(2), 91–118 (1969)
Patriksson, M.: The Traffic Assignment Problem: Models and Methods. VSP, The Netherlands (1994)
Acemoglu, D., Ozdaglar, A.: Competition and efficiency in congested markets. Math. Oper. Res. 32(1), 1–31 (2007)
Acemoglu, D., Srikant, R.: Incentives and prices in communication networks. In: Algorithmic Game Theory. Nisan, N., Roughgarden, T., Tardos, E., Vazirani, V.V. (eds.), pp. 107-132, Cambridge University Press, Cambridge (2007)
Koutsoupias, E., Papadimitriou, C.: Worst-case equilibria. In: Proceedings of the 16th Annual Symposium on Theoretical Aspects of Computer Science, pp. 404–413, (1999)
Koutsoupias, E., Papadimitriou, Ch.: Worst-case equilibria. Comput. Sci. Rev. 3(2), 65–69 (2009)
Monnot, B., Benita, F., Piliouras, G.: Routing games in the wild: efficiency, equilibration and regret. In: Devanur, N.R., Lu, P. (eds.) WINE 2017. LNCS, vol. 10660, pp. 340–353. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-71924-5_24
Colini-Baldeschi, R., Cominetti, R., Mertikopoulos, P., Scarsini, M.: When is selfish routing bad? The price of anarchy in light and heavy traffic. Oper. Res. 68(2), 411–434 (2020)
Wu, Z., Möhring, R,H., Chen, Y., Xu, D.: Selfishness Need Not Be Bad. Oper. Res. 69(2), 410-435 (2021)
Roughgarden, T.: The price of anarchy is independent of the network topology. J. Comput. Syst. Sci. 67(2), 341–364 (2003)
Bagdasaryan, A., Kalampakas, A., Saburov, M.: Dynamic traffic flow assignment on parallel networks. In: Karabegovic, I., Kovačević, A., Mandzuka, S. (eds.) New Technologies, Development and Application VI. NT 2023, LNNS, vol. 687, pp. 702–711. Springer, Cham (2023). https://doi.org/10.1007/978-3-031-31066-9_82
Bagdasaryan, A., Kalampakas, A., Saburov, M., Spartalis, S.: Optimal traffic flow distributions on dynamic networks. In: Iliadis, L., Maglogiannis, I., Alonso, S., Jayne, C., Pimenidis, E. (eds.) Engineering Applications of Neural Networks, EANN 2023, Communications in Computer and Information Science, vol. 1826, pp. 178–190. Springer, Cham (2023). https://doi.org/10.1007/978-3-031-34204-2_16
Kalampakas, A., Bagdasaryan, A., Saburov, M., Spartalis, S.: User equilibrium and system optimality conditions for flow distributions on congested networks. In: Iliadis, L., Maglogiannis, I., Alonso, S., Jayne, C., Pimenidis, E. (eds.) Engineering Applications of Neural Networks, EANN 2023, Communications in Computer and Information Science, vol. 1826, pp. 203–214 Springer, Cham (2023). https://doi.org/10.1007/978-3-031-34204-2_18
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Bagdasaryan, A., Kalampakas, A., Saburov, M. (2024). Discrete-Time Replicator Equations on Parallel Neural Networks. In: Iliadis, L., Maglogiannis, I., Papaleonidas, A., Pimenidis, E., Jayne, C. (eds) Engineering Applications of Neural Networks. EANN 2024. Communications in Computer and Information Science, vol 2141. Springer, Cham. https://doi.org/10.1007/978-3-031-62495-7_37
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