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Visualizing Horizontal Gene Transfer Detection in Phylogenetically Divergent Bacteria

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Bioinformatics and Biomedical Engineering (IWBBIO 2024)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 14849))

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Abstract

Horizontal Gene Transfer (HGT) plays an important and indispensable role in the evolution of bacterial genomes, serving as a mechanism that contributes to genetic diversity and enables adaptation across phylogenetically distant taxa. This study introduces an analysis tool implemented as an R package for detecting HGT events in diverse bacterial lineages. The tool combines the integration of a heat-map matrix with phylogenetic analysis visualization techniques to enhance the accuracy and efficiency of HGT event detection. We applied it to a diverse set of bacterial genomes from chicken and pig gut and expanded the results with established methods for HGT detection. The findings demonstrate the capability of our visualization techniques to pinpoint HGT events, offering a valuable tool for researchers to explore the intricate dynamics of bacterial genome evolution.

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Acknowledgments

This work has been funded by the Czech Science Foundation (22-16786S) to DC.

Computational resources were provided by the e-INFRA CZ project (ID:90140), supported by the Ministry of Education, Youth and Sports of the Czech Republic.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology, Technicka 12, 616 00, Brno, Czech Republic

    Jana Schwarzerova, Laxmipriya Rajasekaran, Katerina Jureckova, Julie Nejezchlebova, Valentine Provaznik & Darina Cejkova

  2. Molecular Systems Biology (MOSYS), University of Vienna, Vienna, Austria

    Jana Schwarzerova & Wolfram Weckwerth

  3. Department of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, Czech Republic

    Jana Schwarzerova

  4. Department of Biology, University of Oxford, Oxfordshire, UK

    Margaret Varga

  5. Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria

    Wolfram Weckwerth

Authors
  1. Jana Schwarzerova
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  2. Laxmipriya Rajasekaran
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  3. Katerina Jureckova
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  4. Julie Nejezchlebova
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  5. Margaret Varga
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  6. Valentine Provaznik
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  7. Wolfram Weckwerth
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  8. Darina Cejkova
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Corresponding author

Correspondence to Jana Schwarzerova .

Editor information

Editors and Affiliations

  1. Department of Computer Architecture, CITIC-UGR - University of Granada, Granada, Granada, Spain

    Ignacio Rojas

  2. Department of Computer Architecture, CITIC-UGR - University of Granada, Granada, Granada, Spain

    Francisco Ortuño

  3. Department of Computer Architecture, CITIC-UGR - University of Granada, Granada, Granada, Spain

    Fernando Rojas

  4. Department of Computer Architecture, CITIC-UGR - University of Granada, Granada, Granada, Spain

    Luis Javier Herrera

  5. Department of Applied Mathematics, University of Granada, Granada, Granada, Spain

    Olga Valenzuela

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Schwarzerova, J. et al. (2024). Visualizing Horizontal Gene Transfer Detection in Phylogenetically Divergent Bacteria. In: Rojas, I., Ortuño, F., Rojas, F., Herrera, L.J., Valenzuela, O. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2024. Lecture Notes in Computer Science(), vol 14849. Springer, Cham. https://doi.org/10.1007/978-3-031-64636-2_20

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  • DOI: https://doi.org/10.1007/978-3-031-64636-2_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-64635-5

  • Online ISBN: 978-3-031-64636-2

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