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A Cellular Automaton Model of the Effects of Maspin on Cell Migration

  • Conference paper
7th International Conference on Practical Applications of Computational Biology & Bioinformatics

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 222))

Abstract

Maspin (Mammary Serine Protease Inhibitor) is a non-inhibitory serpin with multiple cellular effects that is a type II tumour metastasis suppressor. Maspin has been shown to reduce cell migration, invasion, proliferation and angiogenesis, and increase apoptosis and adhesion. In this paper, we report the development of a mathematical model of the effects of maspin on cellular proliferation and migration. An artificial neural network has been used to model the unknown cell signalling to determine the cells fate. Results show that maspin reduces migration by between 10-35%; confirmed by published in vitro data. From our knowledge, this is the first attempt to model maspin effects in a computational model to verify in vitro data. This will provide new insights into to the tumour suppressive properties of maspin and inform the development of novel cancer therapy.

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Author information

Authors and Affiliations

  1. Computational Intelligence Group, Faculty of Engineering and Environment, University of Northumbria, Newcastle, UK

    M. A. Al-Mamun, M. A. Hossain & R. Bass

  2. Department of Applied Physics, Electronics and Communication Engineering, University of Dhaka, Dhaka, 1000, Bangladesh

    M. S. Alam

  3. Department of Applied Sciences, Faculty of Health and Life Sciences, University of Northumbria, Newcastle, UK

    R. Bass

Authors
  1. M. A. Al-Mamun
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  2. M. A. Hossain
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  3. M. S. Alam
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  4. R. Bass
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Corresponding author

Correspondence to M. A. Al-Mamun .

Editor information

Editors and Affiliations

  1. , Department of Software Engineering, Universiti Teknologi Malaysia, Skudai, Johor, 81310, Malaysia

    Mohd Saberi Mohamad

  2. , Department of Information Engineering, Università di Padua, Via Gradenigo 6, Padua, 35122, Italy

    Loris Nanni

  3. , Dep. Informática / CCTC, Universidade do Minho, Braga, 4710 - 057, Portugal

    Miguel P. Rocha

  4. , Department of Informatics, University of Vigo, Ourense, 32004, Spain

    Florentino Fdez-Riverola

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© 2013 Springer International Publishing Switzerland

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Al-Mamun, M.A., Hossain, M.A., Alam, M.S., Bass, R. (2013). A Cellular Automaton Model of the Effects of Maspin on Cell Migration. In: Mohamad, M., Nanni, L., Rocha, M., Fdez-Riverola, F. (eds) 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent Systems and Computing, vol 222. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00578-2_8

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  • DOI: https://doi.org/10.1007/978-3-319-00578-2_8

  • Publisher Name: Springer, Heidelberg

  • Print ISBN: 978-3-319-00577-5

  • Online ISBN: 978-3-319-00578-2

  • eBook Packages: EngineeringEngineering (R0)

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