Abstract
In this work, we present a fully-automatic approach for segmenting bone and marrow structures from dual energy CT (DECT) images. The images are represented using a multi-material decomposition model (MMD) computed from a triplet of physical materials at two different energy attenuation levels. We employ support vector machine learning to select the most relevant MMD model for the anatomical structure of interest so that highly accurate segmentation of the said structures can be achieved. We evaluated our approach for segmenting bone and marrow structures with varying amounts of metastatic bone disease on multiple longitudinal follow up patient scans. Our approach shows consistent and robust segmentation despite changes in bone density due to disease progression, high-density contrast material uptake in neighboring tissue, and significant metal artifacts.
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Pache, G., Krauss, B., Strohm, P., Saueressig, U., Blanke, P., Bulla, S., Schäfer, O., Helwig, P., Kotter, E., Langer, M., et al.: Dual-energy CT virtual noncalcium technique: Detecting posttraumatic bone marrow lesions–feasibility study. Radiology 256(2), 617–624 (2010)
Mendonca, P., Lamb, P., Sahani, D.: A flexible method for multi-material decomposition of dual-energy CT images. IEEE Trans. on Medical Imaging 33(1), 99–116 (2014)
Guyon, I., Weston, J., Barnhill, S., Vapnik, V.: Gene selection for cancer classification using support vector machines. Machine Learning 46(1-3), 389–422 (2002)
Zacharaki, E.I., Wang, S., Chawla, S., Soo Yoo, D., Wolf, R., Melhem, E.R., Davatzikos, C.: Classification of brain tumor type and grade using MRI texture and shape in a machine learning scheme. Magnetic Resonance in Medicine 62(6), 1609–1618 (2009)
Westin, C.F., Warfield, S., Bhalerao, A., Mui, L., Richolt, J., Kikinis, R.: Tensor controlled local structure enhancement of CT images for bone segmentation. In: Wells, W.M., Colchester, A.C.F., Delp, S.L. (eds.) MICCAI 1998. LNCS, vol. 1496, pp. 1205–1212. Springer, Heidelberg (1998)
Shi, J., Malik, J.: Normalized cuts and image segmentation. IEEE Transactions on Pattern Analysis and Machine Intelligence 22(8), 888–905 (2000)
Kang, Y., Engelke, K., Kalender, W.: A new accurate and precise 3D segmentation method for skeletal structures in volumetric CT data. IEEE Trans. on Medical Imaging 22(5), 586–598 (2003)
Gao, Y., Kikinis, R., Bouix, S., Shenton, M., Tannenbaum, A.: A 3D interactive multi-object segmentation tool using local robust statistics driven active contours. Medical Image Analysis 16(6), 1216–1227 (2012)
Vezhnevets, V., Konouchine, V.: GrowCut - Interative multi-label N-D image segmentation. In: Proc. of Graphicon, pp. 150–156 (2005)
Haas, B., Coradi, T., Scholz, M., Kunz, P., Huber, M., Oppitz, U., Andre, L., Lengkeek, V., Huyskens, D., van Esch, A., Reddick, R.: Automatic segmentation of thoracic and pelvic CT images for radiotherapy planning using implicit anatomic knowledge and organ-specific segmentation strategies. Phys. Med. Biol. 53(6), 1751 (2008)
Alvarez, R., Seppi, E.: A comparison of noise and dose in conventional and energy selective computed tomography. IEEE Transactions on Nuclear Science 26(2), 2853–2856 (1979)
Goodsitt, M.M., Rosenthal, D.I., Reinus, W.R., Coumas, J.: Two postprocessing CT techniques for determining the composition of trabecular bone. Investigative Radiology 22(3), 209–215 (1987)
Hubbell, J., Seltzer, S.: NISTIR 5632, National Institute of Standards and Technology, Gaithersburg, MD (1995), http://physics.nist.gov/xaamdi
Veeraraghavan, H., Miller, J.V.: Active learning guided interactions for consistent image segmentation with reduced user interactions. In: Intl. Symposium on Biomedical Imaging (2011)
Bachrach, R.G., Navot, A., Tishby, N.: Margin based feature selection - Theory and algorithms. In: Proc. of Intl. Conf. on Machine Learning (2004)
Chan, T.F., Vese, L.A.: Active contours without edges. IEEE Transactions on Image Processing 10(2), 266–277 (2001)
Caselles, V., Kimmel, R., Sapiro, G.: Geodesic active contours. International Journal of Computer Vision 22(1), 61–79 (1997)
Johnson, H.J., McCormick, M., Ibáñez, L., The Insight Software Consortium: The ITK Software Guide, 3rd edn. Kitware, Inc. (2013) (in press)
Fedorov, A., Beichel, R., Kalpathy-Cramer, J., Finet, J., Fillion-Robin, J., Pujol, S., Bauer, C., Jennings, D., Fennessy, F., Sonka, M., Buatti, J., Aylward, S., Miller, J., Pieper, S., Kikinis, R.: 3D Slicer as an image computing platform for the quantitative imaging network. Magn. Reson. Imaging 30(9), 1323–1341 (2012)
Cour, T., Yu, S., Shi, J.: Normalized cut segmentation code, http://www.cis.upenn.edu/~jshi/software/
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Veeraraghavan, H., Fehr, D., Schmidtlein, R., Hwang, S., Deasy, J.O. (2014). Automatic Bone and Marrow Extraction from Dual Energy CT through SVM Margin-Based Multi-Material Decomposition Model Selection. In: Wu, G., Zhang, D., Zhou, L. (eds) Machine Learning in Medical Imaging. MLMI 2014. Lecture Notes in Computer Science, vol 8679. Springer, Cham. https://doi.org/10.1007/978-3-319-10581-9_19
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DOI: https://doi.org/10.1007/978-3-319-10581-9_19
Publisher Name: Springer, Cham
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