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Cancer—A Story on Fault Propagation in Gene-Cellular Networks

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Propagation Phenomena in Real World Networks

Part of the book series: Intelligent Systems Reference Library ((ISRL,volume 85))

Abstract

We discuss problems related to propagation phenomena in biological networks. As an example we consider processes leading to carcinogenesis and development of cancer, seen as a complex genetic disease from a system theoretic point of view. We present particular regulatory mechanisms which make the cell cycle a fault tolerant system. Then we indicate weak points in this system leading to mutagenesis and cancer progression. The next stage in this cascade of events is related to an angiogenic switch, which in turn may be treated as a trigger of metastasis. All these processes result from communication, competition and subordination between normal and cancer cells. We illustrate interaction processes by models based on evolutionary games and spatial evolutionary games, which describe propagation phenomena in time and space.

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Acknowledgments

We would like to thank Joanna Rzeszowska and Maria Wideł for their valuable biological insight and consultations. This work was partially supported by National Science Centre, Poland, grants DEC-2012/04/A/ST7/00353 (AS, JS, RJ, MK), 2011/03/B/ST6/04384 (DB). Numerical experiments and simulations were performed on the Ziemowit computational cluster (http://www.ziemowit.hpc.polsl.pl/) in the Laboratory of Bioinformatics and Computational Biology, The Biotechnology, Bioengineering and Bioinformatics Centre Silesian BIO-FARMA, created in the POIG.02.01.00-00-166/08 and expanded in the POIG.02.03.01-00-040/13 projects.

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  1. Systems Engineering Group, Faculty of Automatic Control, Electronics and Informatics, Silesian University of Technology, Akademicka 16, 44-100, Gliwice, Poland

    Damian Borys, Roman Jaksik, Michał Krześlak, Jarosław Śmieja & Andrzej Świerniak

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Borys, D., Jaksik, R., Krześlak, M., Śmieja, J., Świerniak, A. (2015). Cancer—A Story on Fault Propagation in Gene-Cellular Networks. In: Król, D., Fay, D., Gabryś, B. (eds) Propagation Phenomena in Real World Networks. Intelligent Systems Reference Library, vol 85. Springer, Cham. https://doi.org/10.1007/978-3-319-15916-4_10

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