Skip to main content

Monitoring Motor Fluctuations in Parkinson’s Disease Using a Waist-Worn Inertial Sensor

  • Conference paper
  • First Online:
Advances in Computational Intelligence (IWANN 2015)

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. First appreciable symptoms in PD are those related to an altered movement control. Current PD treatments temporally revert the symptoms, but they do not prevent disease’s progression. At the beginning of the treatment, the antiparkinsonian effect of the medication is very evident and symptoms may completely disappear for hours; however, as disease progresses, motor fluctuations appear. Collecting precise information on the temporal course of fluctuations is essential for tailoring an optimal therapy in PD patients and is one of the main parameters in clinical trials. This paper presents an algorithm for wearable devices to automatically detect patient’s motor fluctuations based on inertial sensors. The algorithm has been evaluated in 7 PD patients at their homes without supervision and performing their usual activities. Results are a mean sensitivity of 99.9% and a mean specificity of 99.9%.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jankovic, J.: Parkinson’s disease: clinical features and diagnosis. J. Neurol. Neurosurg. Psychiatry 79(4), 368–376 (2008)

    Article  Google Scholar 

  2. Papapetropoulos, S.S.: Patient diaries as a clinical endpoint in Parkinson’s disease clinical trials. CNS Neurosci. Ther. 18(5), 380–387 (2012)

    Article  Google Scholar 

  3. Zwartjes, D., Heida, T., van Vugt, J., Geelen, J., Veltink, P.: Ambulatory Monitoring of Activities and Motor Symptoms in Parkinson’s Disease. IEEE Trans. Biomed. Eng. 57(11), 2778–2786 (2010)

    Article  Google Scholar 

  4. Salarian, A., Russmann, H., Wider, C., Burkhard, P.R., Vingerhoets, F.J.G., Aminian, K.: Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system. IEEE Trans. Biomed. Eng. 54(2), 313–322 (2007)

    Article  Google Scholar 

  5. Pastorino, M., Cancela, J., Arredondo, M.T., Pansera, M., Pastor-Sanz, L., Villagra, F., Pastor, M.A., Martin, J.A.: Assessment of bradykinesia in Parkinson’s disease patients through a multi-parametric system. In: 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC, pp. 1810–1813 (2011)

    Google Scholar 

  6. Cancela, J., Pansera, M., Arredondo, M.T., Estrada, J.J., Pastorino, M., Pastor-Sanz, L., Villalar, J.L.: A comprehensive motor symptom monitoring and management system: The bradykinesia case. In: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 1008–1011 (2010)

    Google Scholar 

  7. Keijsers, N.L.W., Horstink, M.W.I.M., Gielen, S.C.A.M.: Ambulatory motor assessment in Parkinson’s disease. Mov. Disord. 21(1), 34–44 (2006)

    Article  Google Scholar 

  8. Patel, S., Lorincz, K., Hughes, R., Huggins, N., Growdon, J., Standaert, D., Akay, M., Dy, J., Welsh, M., Bonato, P., Member, S.: Monitoring Motor Fluctuations in Patients With Parkinson’s Disease Using Wearable Sensors. IEEE Trans. Inf. Technol. Biomed. 13(6), 864–873 (2009)

    Article  Google Scholar 

  9. Salarian, A., Russmann, H., Vingerhoets, F.J.G., Dehollain, C., Blanc, Y., Burkhard, P.R., Aminian, K.: Gait assessment in Parkinson’s disease: toward an ambulatory system for long-term monitoring. IEEE Trans. Biomed. Eng. 51(8), 1434–1443 (2004)

    Article  Google Scholar 

  10. Hoff, J.I., van der Meer, V., van Hilten, J.J.: Accuracy of Objective Ambulatory Accelerometry in Detecting Motor Complications in Patients With Parkinson Disease. Clin. Neuropharmacol., 27(2) (2004)

    Google Scholar 

  11. Salarian, A.: Ambulatory monitoring of motor functions in patients with parkinson´s disease using kinematic sensors. École polytechnique federale de Lausanne (2006)

    Google Scholar 

  12. Keijsers, N.L.W., Horstink, M.W.I.M., Gielen, S.C.A.M.: Automatic assessment of levodopa-induced dyskinesias in daily life by neural networks. Mov. Disord. 18(1), 70–80 (2003)

    Article  Google Scholar 

  13. Tsipouras, M.G., Tzallas, A.T., Rigas, G., Bougia, P., Fotiadis, D.I., Konitsiotis, S.: Automated Levodopa-induced dyskinesia assessment. In: 2010 Annual International Conference of the IEEE on the Engineering in Medicine and Biology Society (EMBC), pp. 2411–2414 (2010)

    Google Scholar 

  14. Stebbins, G.T., Goetz, C.G., Lang, A.E., Cubo, E.: Factor analysis of the motor section of the unified Parkinson’s disease rating scale during the off-state. Mov. Disord. 14(4), 585–589 (1999)

    Article  Google Scholar 

  15. Mera, T.O., Heldman, D.A., Espay, A.J., Payne, M., Giuffrida, J.P.: Feasibility of home-based automated Parkinson’s disease motor assessment. J. Neurosci. Methods 203(1), 152–156 (2012)

    Article  Google Scholar 

  16. Bloxham, C.C., Mindel, T.C., Frith, C.D.: Initiation and execution of predictable and unpredictable movements in parkinson’s disease. Brain 107(2), 371–384 (1984)

    Article  Google Scholar 

  17. Samà, A., Perez-Lopez, C., Romagosa, J., Rodriguez-Martin, D., Català, A., Cabestany, J., Perez-Martínez, D.A., Rodríguez-Molinero, A.: Dyskinesia and motor state detection in Parkinson’s Disease patients with a single movement sensor. In: 34th Annual International Conference of the IEEE on the Engineering in Medicine and Biology Society, EMBS 2008, pp. 1194–1197 (2012)

    Google Scholar 

  18. Rodriguez-Martin, D., Samà, A., Perez-Lopez, C., Català, A., Cabestany, J., Rodriguez-Molinero, A.: SVM-based posture identification with a single waist-located triaxial accelerometer. Expert Syst. Appl. 40(18), 7203–7211 (2013)

    Article  Google Scholar 

  19. Sama, A., Perez-Lopez, C., Romagosa, J., Rodriguez-Martin, D., Catala, A., Cabestany, J., Perez-Martinez, D.A., Rodriguez-Molinero, A.: Dyskinesia and motor state detection in Parkinson’s Disease patients with a single movement sensor. In: 2012 Annual International Conference of the IEEE on the Engineering in Medicine and Biology Society (EMBC), pp. 1194–1197 (2012)

    Google Scholar 

  20. Zijlstra, W., Hof, A.L.: Assessment of spatio-temporal gait parameters from trunk accelerations during human walking. Gait Posture 18(2), 1–10 (2003)

    Article  Google Scholar 

  21. Rodr’iguez-Molinero, A., Samà, A., Pérez-Mart’inez, A.D., Pérez López, C., Romagosa, J., Bayés, À., Sanz, P., Calopa, M., Gálvez-Barrón, C., de Mingo, E., Rodr’iguez Mart’in, D., Gonzalo, N., Formiga, F., Cabestany, J., Catalá, A.: Validation of a Portable Device for Mapping Motor and Gait Disturbances in Parkinson’s Disease. JMIR mHealth uHealth 3(1), e9 (2015)

    Article  Google Scholar 

  22. Vapnik, V.N.: The Nature of Statistical Learning Theory, Second. Springer-Verlag, New York (1995)

    Book  Google Scholar 

  23. C.A. Rodríguez-Molinero, A., Samà, A., Pérez-Martínez, D.A., Pérez-López, C., Romagosa, J., Bayés, A., Sanz, P., Calopa, M., Ruiz, J., Gálvez, C., de Mingo, E., Rodríguez-Martín, D., Gonzalo, N., Formiga, F., Cabestany, J.: Validation of a Portable Device for Mapping Motor and Gait Disturbances in Parkinson’s Disease. JMIR MHEALTH UHEALTH - Press

    Google Scholar 

  24. Rodríguez-Martín, D., Pérez-López, C., Samà, A., Cabestany, J., Català, A.: A Wearable Inertial Measurement Unit for Long-Term Monitoring in the Dependency Care Area. Sensors 13(10), 14079–14104 (2013)

    Article  Google Scholar 

  25. Cavanaugh, J.T., Ellis, T.D., Earhart, G.M., Ford, M.P., Foreman, K.B., Dibble, L.E.: Capturing Ambulatory Activity Decline in Parkinson Disease. J. Neurol. Phys. Ther. JNPT 36(2), 51 (2012)

    Article  Google Scholar 

  26. Rochester, L., Chastin, S.F.M., Lord, S., Baker, K., Burn, D.J.: Understanding the impact of deep brain stimulation on ambulatory activity in advanced Parkinson’s disease. J. Neurol. 259(6), 1081–1086 (2012)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carlos Pérez-López .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this paper

Cite this paper

Pérez-López, C. et al. (2015). Monitoring Motor Fluctuations in Parkinson’s Disease Using a Waist-Worn Inertial Sensor . In: Rojas, I., Joya, G., Catala, A. (eds) Advances in Computational Intelligence. IWANN 2015. Lecture Notes in Computer Science(), vol 9094. Springer, Cham. https://doi.org/10.1007/978-3-319-19258-1_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-19258-1_38

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19257-4

  • Online ISBN: 978-3-319-19258-1

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics