Abstract
Adverse drug events (ADEs) are a major concern and point of emphasis for the medical profession, government, and society in general. When methods extract ADEs from observational data, there is a necessity to evaluate these methods. More precisely, it is important to know what is already known in the literature. Consequently, we employ a novel relation extraction technique based on a recently developed probabilistic logic learning algorithm that exploits human advice. We demonstrate on a standard adverse drug events data base that the proposed approach can successfully extract existing adverse drug events from limited amount of training data and compares favorably with state-of-the-art probabilistic logic learning methods.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Blockeel, H.: Top-down induction of first order logical decision trees. AI Communications 12(1-2) (1999)
Cristianini, N.: Shawe-Taylor: An Introduction to Support Vector Machines and Other Kernel-based Learning Methods. Cambridge University Press (2000)
Finkel, J., Grenager, T., Manning, C.: Incorporating non-local information into information extraction systems by gibbs sampling. In: Proceedings of the 43rd Annual Meeting on Association for Computational Linguistics, ACL 2005, pp. 363–370. Association for Computational Linguistics (2005)
Friedman, J.: Greedy function approximation: A gradient boosting machine. In: Annals of Statistics (2001)
Gurwitz, J., Field, T., L, Harrold, R.J., Kebellis, K., Seger, A.: Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 289 (2003)
Gutmann, B., Kersting, K.: TildeCRF: Conditional random fields for logical sequences. In: Fürnkranz, J., Scheffer, T., Spiliopoulou, M. (eds.) ECML 2006. LNCS (LNAI), vol. 4212, pp. 174–185. Springer, Heidelberg (2006)
Kang, N., Singh, B., Bui, C., Afzal, Z., van Mulligen, E.M., Kors, J.: Knowledge-based extraction of adverse drug events from biomedical text. BMC Bioinformatics 15 (2014)
Karwath, A., Kersting, K., Landwehr, N.: Boosting relational sequence alignments. In: ICDM (2008)
Kersting, K., Driessens, K.: Non-parametric policy gradients: A unified treatment of propositional and relational domains. In: ICML (2008)
Klein, D., Manning, C.: Accurate unlexicalized parsing. In: Proceedings of the 41st Annual Meeting on Association for Computational Linguistics, vol. 1, pp. 423–430. Association for Computational Linguistics (2003)
Mitchell, T.: Machine Learning. McGraw-Hill (1997)
Natarajan, S., Bangera, V., Khot, T., Picado, J.: et al.: A novel text-based method for evaluation of adverse drug event discovery. Journal of Biomedical Informatics (2015) (under review)
Natarajan, S., Joshi, S., Tadepalli, P., Kersting, K., Shavlik, J.: Imitation learning in relational domains: A functional-gradient boosting approach. In: IJCAI (2011)
Natarajan, S., Khot, T., Kersting, K., Gutmann, B., Shavlik, J.: Gradient-based boosting for statistical relational learning: The relational dependency network case. Machine Learning 86(1) (2012)
Odom, P., Khot, T., Porter, R., Natarajan, S.: Knowledge-based probabilistic logic learning. In: AAAI (2015)
Ryan, P., Welebob, E., Hartzema, A.G., Stang, P., Overhage, J.M.: Surveying us observational data sources and characteristics for drug safety needs. Pharmaceutical Medicine, 231–238 (2010)
Schapire, R., Freund, Y.: Boosting: Foundations and Algorithms. MIT Press (2012)
Yang, S., Khot, T., Kersting, K., Kunapuli, G., Hauser, K., Natarajan, S.: Learning from imbalanced data in relational domains: A soft margin approach. In: ICDM (2014)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
Odom, P., Bangera, V., Khot, T., Page, D., Natarajan, S. (2015). Extracting Adverse Drug Events from Text Using Human Advice. In: Holmes, J., Bellazzi, R., Sacchi, L., Peek, N. (eds) Artificial Intelligence in Medicine. AIME 2015. Lecture Notes in Computer Science(), vol 9105. Springer, Cham. https://doi.org/10.1007/978-3-319-19551-3_26
Download citation
DOI: https://doi.org/10.1007/978-3-319-19551-3_26
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-19550-6
Online ISBN: 978-3-319-19551-3
eBook Packages: Computer ScienceComputer Science (R0)